MOUSE:BACE1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bace1 (synonyms: Bace)
Protein Name(s)	Beta-secretase 1 Aspartyl protease 2 ASP2 Asp 2 Beta-site amyloid precursor protein cleaving enzyme 1 Beta-site APP cleaving enzyme 1 Memapsin-2 Membrane-associated aspartic protease 2
External Links
UniProt	P56818
EMBL	AF190726 AF200346 AK014464 AK033112 AK041285 BC048189
CCDS	CCDS23135.1
RefSeq	NP_001139419.1 NP_035922.4
UniGene	Mm.24044
ProteinModelPortal	P56818
SMR	P56818
BioGrid	204741
BindingDB	P56818
ChEMBL	CHEMBL4593
MEROPS	A01.004
PhosphoSite	P56818
MaxQB	P56818
PRIDE	P56818
Ensembl	ENSMUST00000034591
GeneID	23821
KEGG	mmu:23821
UCSC	uc009pgh.2
CTD	23621
MGI	MGI:1346542
eggNOG	NOG71700
GeneTree	ENSGT00760000118929
HOGENOM	HOG000036572
HOVERGEN	HBG059578
InParanoid	P56818
KO	K04521
OMA	YLMSENH
OrthoDB	EOG7DNNVW
PhylomeDB	P56818
TreeFam	TF329595
BRENDA	3.4.23.46
ChiTaRS	Bace1
NextBio	303471
PRO	PR:P56818
Proteomes	UP000000589
Bgee	P56818
CleanEx	MM_BACE1
ExpressionAtlas	P56818
Genevestigator	P56818
GO	GO:0030424 GO:0009986 GO:0031410 GO:0030659 GO:0005783 GO:0005768 GO:0005794 GO:0005887 GO:0016020 GO:0005771 GO:0005802 GO:0004190 GO:0001540 GO:0004175 GO:0050435 GO:0006508
Gene3D	2.40.70.10
InterPro	IPR001461 IPR001969 IPR009119 IPR009120 IPR021109
PANTHER	PTHR13683
Pfam	PF00026
PRINTS	PR01816 PR01815 PR00792
SUPFAM	SSF50630
PROSITE	PS00141

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0055037	recycling endosome	PMID:23931995^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:19074428^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:19074428^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:20943921^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49582	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:18753368^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098686) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:23820808^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098686) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:23820808^[5]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098686) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:23820808^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:23820808^[5]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:18753368^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817	P		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000201569 PANTHER:PTN000342793 UniProtKB:P0CY27 UniProtKB:Q5A8N2 UniProtKB:Q5AC08	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 MGI:MGI:1860440 PANTHER:PTN002299446 UniProtKB:P56817 UniProtKB:Q9Y5Z0	C		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002299446 UniProtKB:P56817 UniProtKB:Q9Y5Z0	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000190503 CGD:CAL0000194661 CGD:CAL0000196689 CGD:CAL0000201140 MGI:MGI:1346542 PANTHER:PTN000342793 RGD:621511 SGD:S000002551 TAIR:locus:2008940 UniProtKB:P00797 UniProtKB:P0CY27 UniProtKB:P41748 UniProtKB:P43094 UniProtKB:P56817 UniProtKB:Q59VH7 UniProtKB:Q5AC08 UniProtKB:Q8I6Z5 WB:WBGene00000217	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817 UniProtKB:Q9Y5Z0	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346542 PANTHER:PTN002299446 RGD:2191 UniProtKB:P56817	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000196689 MGI:MGI:107361 MGI:MGI:1915935 MGI:MGI:88562 PANTHER:PTN000342793 PomBase:SPCC1795.09 RGD:2446 SGD:S000001277 SGD:S000002551 SGD:S000004110 SGD:S000004111 TAIR:locus:2145954 UniProtKB:P00797 UniProtKB:P0CY27 UniProtKB:P14091 UniProtKB:P20142 UniProtKB:P56817 UniProtKB:Q4WNV0 UniProtKB:Q5AC08 UniProtKB:Q8I6Z5 UniProtKB:Q9LTW4 UniProtKB:Q9Y5Z0	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000343246 UniProtKB:P56817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060134	prepulse inhibition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	PMID:25592972^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(MGI:MGI:88059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:11740561^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:11740561^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15886206^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:26467158^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	PMID:15123597^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:25592972^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2191	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:25592972^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:15123597^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56819 ensembl:ENSRNOP00000022796	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56817 ensembl:ENSP00000318585	F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009119 InterPro:IPR009120	C		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:19118188^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:19118188^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:20943921^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_o_occurs_in:(GO:0097471)	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Das, U et al. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79 447-60 PubMed GONUTS page
↑ ^2.0 ^2.1 Vetrivel, KS et al. (2009) Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J. Biol. Chem. 284 3793-803 PubMed GONUTS page
↑ ^3.0 ^3.1 Wang, H et al. (2010) Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. J. Neurosci. 30 13808-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Wang, H et al. (2008) BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. J. Neurosci. 28 8677-81 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kandalepas, PC et al. (2013) The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 126 329-52 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kizuka, Y et al. (2015) An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med 7 175-89 PubMed GONUTS page
↑ ^8.0 ^8.1 Kamal, A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414 643-8 PubMed GONUTS page
↑ Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page
↑ Kizuka, Y et al. (2016) Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem. J. 473 21-30 PubMed GONUTS page
↑ ^11.0 ^11.1 Rossner, S et al. (2004) Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing. J. Biol. Chem. 279 27841-4 PubMed GONUTS page
↑ ^12.0 ^12.1 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page

[PMID:23931995-1] Das, U et al. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79 447-60 PubMed GONUTS page

[PMID:19074428-2] 2.0 ^2.1 Vetrivel, KS et al. (2009) Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J. Biol. Chem. 284 3793-803 PubMed GONUTS page

[PMID:20943921-3] 3.0 ^3.1 Wang, H et al. (2010) Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. J. Neurosci. 30 13808-13 PubMed GONUTS page

[PMID:18753368-4] 4.0 ^4.1 Wang, H et al. (2008) BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. J. Neurosci. 28 8677-81 PubMed GONUTS page

[PMID:23820808-5] 5.0 ^5.1 ^5.2 ^5.3 Kandalepas, PC et al. (2013) The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 126 329-52 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25592972-7] 7.0 ^7.1 ^7.2 Kizuka, Y et al. (2015) An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med 7 175-89 PubMed GONUTS page

[PMID:11740561-8] 8.0 ^8.1 Kamal, A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414 643-8 PubMed GONUTS page

[PMID:15886206-9] Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page

[PMID:26467158-10] Kizuka, Y et al. (2016) Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem. J. 473 21-30 PubMed GONUTS page

[PMID:15123597-11] 11.0 ^11.1 Rossner, S et al. (2004) Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing. J. Biol. Chem. 279 27841-4 PubMed GONUTS page

[PMID:19118188-12] 12.0 ^12.1 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page

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