MOUSE:B7ZWM4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Duox2 (ECO:0000313 with EMBL:AAI72138.1, ECO:0000313 with MGI:MGI:3036280)
Protein Name(s)	Duox2 protein (ECO:0000313 with EMBL:AAI72138.1)
External Links
UniProt	B7ZWM4
EMBL	BC172138
UniGene	Mm.358846
MGI	MGI:3036280
HOVERGEN	HBG080428
NextBio	35547770
Genevestigator	B7ZWM4
GO	GO:0016021 GO:0005509 GO:0020037 GO:0016174 GO:0004601 GO:0048855 GO:0030282 GO:0009566 GO:0042445 GO:0048839 GO:0035264 GO:0006979 GO:0030878 GO:0006590 GO:0042403
Gene3D	1.10.238.10 1.10.640.10
InterPro	IPR029592 IPR011992 IPR018247 IPR002048 IPR013112 IPR017927 IPR013130 IPR013121 IPR010255 IPR019791 IPR017938
PANTHER	PTHR11972:SF53
Pfam	PF03098 PF13499 PF08022 PF01794 PF08030
PRINTS	PR00457
SMART	SM00054
SUPFAM	SSF48113 SSF63380
PROSITE	PS00018 PS50222 PS51384 PS50292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002544	chronic inflammatory response	PMID:23860501^[1]	ECO:0000314			P		Figure 1(E) uses immunostaining of DUOX proteins in DOUX K/O mice and W/T mice. DUOX levels are much higher in W/T mice, particularly toward the apical surface of the epithelium, than it is in K/O mice. This shows that over-expression of DUOX is part of the immune/inflammatory response to Helicobacter felis in mice.	complete CACAO 9933
involved_in	GO:0055114	oxidation-reduction process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN001735877 PomBase:SPBC1683.09c RGD:620600 SGD:S000003128 SGD:S000004037 SGD:S000005512 TAIR:locus:2017789 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2025366 TAIR:locus:2157032 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 TAIR:locus:2178677 TAIR:locus:2178687 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9NPH5 UniProtKB:Q9NRD8 UniProtKB:Q9SBI0 UniProtKB:Q9Y5S8 WB:WBGene00000253 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	P		Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN000239643 RGD:620574 RGD:620598 RGD:620600 UniProtKB:P04839 UniProtKB:Q9Y5S8	C		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 RGD:620598 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101	P		Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	F		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:88574 PANTHER:PTN000239643 UniProtKB:P04839 ZFIN:ZDB-GENE-091117-14 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653 dictyBase:DDB_G0291117	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2139422 MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN001735877 RGD:620574 RGD:620598 RGD:620600 SGD:S000005512 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2157027 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 UniProtKB:O81209 UniProtKB:P04839 UniProtKB:Q9Y5S8 WB:WBGene00000253	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000147	positive regulation of cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090303	positive regulation of wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051591	response to cAMP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048855	adenohypophysis morphogenesis	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P	has_participant:(EMAPA:17514)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P	results_in_development_of:(EMAPA:16194)	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042554	superoxide anion generation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042445	hormone metabolic process	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042403	thyroid hormone metabolic process	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030878	thyroid gland development	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P	results_in_development_of:(EMAPA:17068)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009615	response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009566	fertilization	PMID:17440044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3712359	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NRD8	F		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034818	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F		Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034818	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Grasberger, H et al. (2013) Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology 145 1045-54 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Johnson, KR et al. (2007) Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. Mol. Endocrinol. 21 1593-602 PubMed GONUTS page

[PMID:23860501-1] Grasberger, H et al. (2013) Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology 145 1045-54 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17440044-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Johnson, KR et al. (2007) Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. Mol. Endocrinol. 21 1593-602 PubMed GONUTS page

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MOUSE:B7ZWM4

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