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PMID:23860501
| Citation |
Grasberger, H, El-Zaatari, M, Dang, DT and Merchant, JL (2013) Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology 145:1045-54 |
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| Abstract |
Dual oxidases (DUOX) are conserved reduced nicotinamide adenine dinucleotide phosphate oxidases that produce H2O2 at the epithelial cell surface. The DUOX enzyme comprises the DUOX and DUOX maturation factor (DUOXA) subunits. Mammalian genomes encode 2 DUOX isoenzymes (DUOX1/DUOXA1 and DUOX2/DUOXA2). Expression of these genes is up-regulated during bacterial infections and chronic inflammatory diseases of the luminal gastrointestinal tract. The roles of DUOX in cellular interactions with microbes have not been determined in higher vertebrates. |
| Links |
PubMed PMC3805753 Online version:10.1053/j.gastro.2013.07.011 |
| Keywords |
Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelium/metabolism; Epithelium/microbiology; Female; Gastric Mucosa/metabolism; Gastric Mucosa/microbiology; Gastritis/metabolism; Gastritis/prevention & control; Helicobacter Infections/metabolism; Helicobacter Infections/prevention & control; Helicobacter felis/drug effects; Hydrogen Peroxide/metabolism; Hydrogen Peroxide/pharmacology; Membrane Proteins/deficiency; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Mice, Knockout; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nuclear Proteins/deficiency; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Stomach/metabolism; Stomach/microbiology; Up-Regulation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002544: chronic inflammatory response |
ECO:0000314: |
P |
Figure 1(E) uses immunostaining of DUOX proteins in DOUX K/O mice and W/T mice. DUOX levels are much higher in W/T mice, particularly toward the apical surface of the epithelium, than it is in K/O mice. This shows that over-expression of DUOX is part of the immune/inflammatory response to Helicobacter felis in mice. |
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Notes
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