MOUSE:B2MG

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	B2m
Protein Name(s)	Beta-2-microglobulin
External Links
UniProt	P01887
EMBL	X01838 M12485 M84363 M84364 M84365 M84366 M84367 AK019389 AK028378 AK166067 AL845457 CH466519 BC085164 M10389 M10416
CCDS	CCDS16654.1
PIR	A90822
RefSeq	NP_033865.2
PDB	1BII 1BQH 1BZ9 1CD1 1DDH 1FFN 1FFO 1FFP 1FG2 1FO0 1FZJ 1FZK 1FZM 1FZO 1G6R 1G7P 1G7Q 1HOC 1INQ 1JPF 1JPG 1JUF 1K8D 1KBG 1KJ2 1KJ3 1KPU 1KPV 1L6Q 1LD9 1LDP 1LEG 1LEK 1LK2 1MHC 1MWA 1N3N 1N59 1N5A 1NAM 1NAN 1NEZ 1OSZ 1P1Z 1P4L 1PQZ 1QO3 1RJY 1RJZ 1RK0 1RK1 1S7Q 1S7R 1S7S 1S7T 1S7U 1S7V 1S7W 1S7X 1T0M 1T0N 1U58 1VAC 1VAD 1WBX 1WBY 1WBZ 1YN6 1YN7 1Z5L 1ZHB 1ZHN 1ZT1 1ZT7 2AKR 2CKB 2CLV 2CLZ 2FIK 2FO4 2FWO 2GAZ 2MHA 2OL3 2Q7Y 2QRI 2QRS 2QRT 2VAA 2VAB 2VE6 2ZOK 2ZOL 2ZSV 2ZSW 3ARB 3ARD 3ARE 3ARF 3ARG 3AU1 3BUY 3C8K 3CC5 3CCH 3CH1 3CPL 3CVH 3DMM 3E6F 3E6H 3ECB 3FOL 3FOM 3FON 3FTG 3G08 3GML 3GMM 3GMN 3GMO 3GMP 3GMQ 3GMR 3HE6 3HE7 3ILP 3ILQ 3L3H 3MA7 3NWM 3O8X 3O9W 3P4M 3P4N 3P4O 3P9L 3P9M 3PAB 3PQY 3PWU 3QI9 3QUK 3QUL 3QUX 3QUY 3QUZ 3RGV 3ROL 3ROO 3RTQ 3RUG 3RZC 3SCM 3SDA 3SDC 3SDD 3T1F 3TA3 3TBS 3TBT 3TBV 3TBW 3TBY 3TN0 3TO4 3TVM 3UBX 3VJ6 3WS3 3WS6 4APQ 4EI5 4ELM 4HS3 4HUU 4HUV 4HUW 4HUX 4HV8 4IHO 4IRJ 4IRS 4L8B 4L8C 4L8D 4MNG 4MQ7 4MX7 4NSK 4PG2 4PG9 4PGB 4PGC 4PGD 4PGE 4PV8 4PV9 4Y16 4Y2D 4Y4F 4Y4H 4Y4K 4ZAK 4ZUS 4ZUT 4ZUU 4ZUV 4ZUW 5E8N 5E8O 5E8P 5EFI 5FKP 5IVX 5J6G 5J6H 5JWD 5JWE 5KD4 5KD7 5M00 5M02 5MZM 5OQF 5OQG 5OQH 5OQI 5SWS 5SWZ 5T7G 5TIL 5TJE 5TW2 5TW5 5VCJ 5VCL 5WES 5WET 5WEU 5WLG 5WLI 6A97 6BMH 6BMK 6BNK 6BNL 6C5M 6C69 6C6A 6C6C 6C6E 6C6F 6C6H 6C6J 6CW6 6CW9 6CWB 6CWE 6CX5 6CX7 6CX9 6CXA 6CXE 6CXF 6CYW 6E1I 6G9Q 6G9R 6GB5 6GB6 6GB7 6MIV 6MIY 6MJ4 6MJ6 6MJA 6MJI 6MJJ 6MJQ 6MP0 6MP1 6OOR
PDBsum	1BII 1BQH 1BZ9 1CD1 1DDH 1FFN 1FFO 1FFP 1FG2 1FO0 1FZJ 1FZK 1FZM 1FZO 1G6R 1G7P 1G7Q 1HOC 1INQ 1JPF 1JPG 1JUF 1K8D 1KBG 1KJ2 1KJ3 1KPU 1KPV 1L6Q 1LD9 1LDP 1LEG 1LEK 1LK2 1MHC 1MWA 1N3N 1N59 1N5A 1NAM 1NAN 1NEZ 1OSZ 1P1Z 1P4L 1PQZ 1QO3 1RJY 1RJZ 1RK0 1RK1 1S7Q 1S7R 1S7S 1S7T 1S7U 1S7V 1S7W 1S7X 1T0M 1T0N 1U58 1VAC 1VAD 1WBX 1WBY 1WBZ 1YN6 1YN7 1Z5L 1ZHB 1ZHN 1ZT1 1ZT7 2AKR 2CKB 2CLV 2CLZ 2FIK 2FO4 2FWO 2GAZ 2MHA 2OL3 2Q7Y 2QRI 2QRS 2QRT 2VAA 2VAB 2VE6 2ZOK 2ZOL 2ZSV 2ZSW 3ARB 3ARD 3ARE 3ARF 3ARG 3AU1 3BUY 3C8K 3CC5 3CCH 3CH1 3CPL 3CVH 3DMM 3E6F 3E6H 3ECB 3FOL 3FOM 3FON 3FTG 3G08 3GML 3GMM 3GMN 3GMO 3GMP 3GMQ 3GMR 3HE6 3HE7 3ILP 3ILQ 3L3H 3MA7 3NWM 3O8X 3O9W 3P4M 3P4N 3P4O 3P9L 3P9M 3PAB 3PQY 3PWU 3QI9 3QUK 3QUL 3QUX 3QUY 3QUZ 3RGV 3ROL 3ROO 3RTQ 3RUG 3RZC 3SCM 3SDA 3SDC 3SDD 3T1F 3TA3 3TBS 3TBT 3TBV 3TBW 3TBY 3TN0 3TO4 3TVM 3UBX 3VJ6 3WS3 3WS6 4APQ 4EI5 4ELM 4HS3 4HUU 4HUV 4HUW 4HUX 4HV8 4IHO 4IRJ 4IRS 4L8B 4L8C 4L8D 4MNG 4MQ7 4MX7 4NSK 4PG2 4PG9 4PGB 4PGC 4PGD 4PGE 4PV8 4PV9 4Y16 4Y2D 4Y4F 4Y4H 4Y4K 4ZAK 4ZUS 4ZUT 4ZUU 4ZUV 4ZUW 5E8N 5E8O 5E8P 5EFI 5FKP 5IVX 5J6G 5J6H 5JWD 5JWE 5KD4 5KD7 5M00 5M02 5MZM 5OQF 5OQG 5OQH 5OQI 5SWS 5SWZ 5T7G 5TIL 5TJE 5TW2 5TW5 5VCJ 5VCL 5WES 5WET 5WEU 5WLG 5WLI 6A97 6BMH 6BMK 6BNK 6BNL 6C5M 6C69 6C6A 6C6C 6C6E 6C6F 6C6H 6C6J 6CW6 6CW9 6CWB 6CWE 6CX5 6CX7 6CX9 6CXA 6CXE 6CXF 6CYW 6E1I 6G9Q 6G9R 6GB5 6GB6 6GB7 6MIV 6MIY 6MJ4 6MJ6 6MJA 6MJI 6MJJ 6MJQ 6MP0 6MP1 6OOR
SMR	P01887
BioGrid	198291
DIP	DIP-6111N
IntAct	P01887
MINT	P01887
STRING	10090.ENSMUSP00000099534
iPTMnet	P01887
PhosphoSitePlus	P01887
SWISS-2DPAGE	P01887
CPTAC	non-CPTAC-3965
EPD	P01887
jPOST	P01887
PaxDb	P01887
PeptideAtlas	P01887
PRIDE	P01887
Ensembl	ENSMUST00000102476
GeneID	12010
KEGG	mmu:12010
UCSC	uc008maf.1
CTD	567
MGI	MGI:88127
eggNOG	ENOG410J15A ENOG410YTDG
GeneTree	ENSGT00690000102227
HOGENOM	HOG000043084
InParanoid	P01887
KO	K08055
OMA	PNFLNCY
OrthoDB	1556447at2759
TreeFam	TF334167
Reactome	R-MMU-1236974 R-MMU-1236977 R-MMU-198933 R-MMU-2172127 R-MMU-2424491 R-MMU-6798695 R-MMU-983170
EvolutionaryTrace	P01887
PMAP-CutDB	P01887
PRO	PR:P01887
Proteomes	UP000000589
Bgee	ENSMUSG00000060802
Genevisible	P01887
GO	GO:0005829 GO:0009897 GO:0005615 GO:0005794 GO:1990712 GO:0042824 GO:0042612 GO:0030670 GO:0005886 GO:0042802 GO:0042803 GO:1990000 GO:0019885 GO:0002481 GO:0006968 GO:0071281 GO:0071283 GO:0071316 GO:0006955 GO:0055072 GO:0006826 GO:0007611 GO:0090647 GO:0007275 GO:0050680 GO:2000978 GO:0050768 GO:0010977 GO:1900121 GO:2000774 GO:1904434 GO:0032092 GO:1900122 GO:0048260 GO:0002726 GO:0001916 GO:1904437 GO:0051289 GO:0042026 GO:0045646 GO:0034756 GO:0046686 GO:0002237 GO:0033077
CDD	cd05770
Gene3D	2.60.40.10
InterPro	IPR015707 IPR007110 IPR036179 IPR013783 IPR003006 IPR003597
PANTHER	PTHR19944:SF62
Pfam	PF07654
SMART	SM00407
SUPFAM	SSF48726
PROSITE	PS50835 PS00290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes
involved_in	GO:0007611	learning or memory	PMID:28864206^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt
involved_in	GO:2000978	negative regulation of forebrain neuron differentiation	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002608) part_of:(GO:0007568)	Seeded From UniProt
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885) regulates_o_occurs_in:(UBERON:0001885) occurs_in:(UBERON:0007023) regulates_o_occurs_in:(UBERON:0007023) part_of:(GO:0007568)	Seeded From UniProt
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0007611	learning or memory	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007568) occurs_in:(UBERON:0002421)	Seeded From UniProt
involved_in	GO:0007275	multicellular organism development	PMID:10912502^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:24006456^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt
acts_upstream_of_or_within	GO:2000978	negative regulation of forebrain neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:2000774	positive regulation of cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
part_of	GO:1990712	HFE-transferrin receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
acts_upstream_of_or_within	GO:1990000	amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1904437	positive regulation of transferrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1904434	positive regulation of ferrous iron binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1900122	positive regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1900121	negative regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071283	cellular response to iron(III) ion	PMID:9531620^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927183	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071281	cellular response to iron ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:11113132^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050768	negative regulation of neurogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0045646	regulation of erythrocyte differentiation	PMID:9531620^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927183	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0045087	innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	F		Seeded From UniProt
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	F		Seeded From UniProt
acts_upstream_of_or_within	GO:0042026	protein refolding	PMID:16920948^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(MGI:MGI:2179988)\|has_direct_input:(MGI:MGI:2179989)	Seeded From UniProt
acts_upstream_of_or_within	GO:0034756	regulation of iron ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:18776904^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95663	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0019731	antibacterial humoral response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	PMID:20018625^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95896	P		Seeded From UniProt
part_of	GO:0009897	external side of plasma membrane	PMID:1538753^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0006826	iron ion transport	PMID:9531620^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927183	P		Seeded From UniProt
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2189	C		Seeded From UniProt
acts_upstream_of_or_within	GO:0003254	regulation of membrane depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0002726	positive regulation of T cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	PMID:16299293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0002237	response to molecule of bacterial origin	PMID:16299293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0001916	positive regulation of T cell mediated cytotoxicity	PMID:16299293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07151 ensembl:ENSRNOP00000023017	P		Seeded From UniProt
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07151 ensembl:ENSRNOP00000023017	P		Seeded From UniProt
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07151 ensembl:ENSRNOP00000023017	C		Seeded From UniProt
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015707	P		Seeded From UniProt
part_of	GO:0042612	MHC class I protein complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015707	C		Seeded From UniProt
part_of	GO:0030670	phagocytic vesicle membrane	Reactome:R-NUL-1236962	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt
acts_upstream_of_or_within	GO:0006968	cellular defense response	PMID:2685607^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt
involved_in	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0490	P		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt
part_of	GO:0042612	MHC class I protein complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0490	C		Seeded From UniProt
involved_in	GO:0007611	learning or memory	PMID:28864206^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt
involved_in	GO:2000978	negative regulation of forebrain neuron differentiation	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002608) part_of:(GO:0007568)	Seeded From UniProt
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885) regulates_o_occurs_in:(UBERON:0001885) occurs_in:(UBERON:0007023) regulates_o_occurs_in:(UBERON:0007023) part_of:(GO:0007568)	Seeded From UniProt
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0007611	learning or memory	PMID:26147761^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007568) occurs_in:(UBERON:0002421)	Seeded From UniProt
involved_in	GO:0007275	multicellular organism development	PMID:10912502^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:24006456^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt
part_of	GO:0030670	phagocytic vesicle membrane	Reactome:R-NUL-1236962	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt
acts_upstream_of_or_within	GO:2000978	negative regulation of forebrain neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:2000774	positive regulation of cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
part_of	GO:1990712	HFE-transferrin receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
acts_upstream_of_or_within	GO:1990000	amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1904437	positive regulation of transferrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1904434	positive regulation of ferrous iron binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1900122	positive regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:1900121	negative regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071283	cellular response to iron(III) ion	PMID:9531620^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927183	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071281	cellular response to iron ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:11113132^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050768	negative regulation of neurogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0045646	regulation of erythrocyte differentiation	PMID:9531620^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927183	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0045087	innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	F		Seeded From UniProt
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	F		Seeded From UniProt
acts_upstream_of_or_within	GO:0042026	protein refolding	PMID:16920948^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(MGI:MGI:2179988)\|has_direct_input:(MGI:MGI:2179989)	Seeded From UniProt
acts_upstream_of_or_within	GO:0034756	regulation of iron ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:18776904^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95663	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0019731	antibacterial humoral response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	PMID:20018625^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95896	P		Seeded From UniProt
part_of	GO:0009897	external side of plasma membrane	PMID:1538753^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0006968	cellular defense response	PMID:2685607^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0006826	iron ion transport	PMID:9531620^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927183	P		Seeded From UniProt
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	C		Seeded From UniProt
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2189	C		Seeded From UniProt
enables	GO:0005515	protein binding	PMID:16920948^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8HWE6 UniProtKB:Q8HWE7	F		Seeded From UniProt
enables	GO:0005515	protein binding	PMID:14735325^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14427	F		Seeded From UniProt
acts_upstream_of_or_within	GO:0003254	regulation of membrane depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0002726	positive regulation of T cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61769	P		Seeded From UniProt
acts_upstream_of_or_within	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	PMID:16299293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0002237	response to molecule of bacterial origin	PMID:16299293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
acts_upstream_of_or_within	GO:0001916	positive regulation of T cell mediated cytotoxicity	PMID:16299293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07151 ensembl:ENSRNOP00000023017	P		Seeded From UniProt
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07151 ensembl:ENSRNOP00000023017	P		Seeded From UniProt
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07151 ensembl:ENSRNOP00000023017	C		Seeded From UniProt
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015707	P		Seeded From UniProt
part_of	GO:0042612	MHC class I protein complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015707	C		Seeded From UniProt
involved_in	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0490	P		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt
part_of	GO:0042612	MHC class I protein complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0490	C		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C		Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shimbo, A et al. (2018) Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits. Behav. Brain Res. 336 156-165 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Smith, LK et al. (2015) β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat. Med. 21 932-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Bard, J et al. (2000) Effect of B2m gene disruption on MHC-determined odortypes. Immunogenetics 51 514-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Santos, M et al. (1998) Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice. Blood 91 3059-65 PubMed GONUTS page
↑ ^6.0 ^6.1 Pigeon, C et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 7811-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kajikawa, M et al. (2006) MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression. J. Immunol. 177 3108-15 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang, L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. Immunol. 9 1122-30 PubMed GONUTS page
↑ ^9.0 ^9.1 Escande-Beillard, N et al. (2010) Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J. Immunol. 184 816-23 PubMed GONUTS page
↑ ^10.0 ^10.1 Attaya, M et al. (1992) Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature 355 647-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Ugrinovic, S et al. (2005) H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium. Infect. Immun. 73 8002-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Zijlstra, M et al. (1989) Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342 435-8 PubMed GONUTS page
↑ Lilić, M et al. (2004) Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain. Immunogenetics 55 740-7 PubMed GONUTS page

[PMID:28864206-1] 1.0 ^1.1 Shimbo, A et al. (2018) Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits. Behav. Brain Res. 336 156-165 PubMed GONUTS page

[PMID:26147761-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Smith, LK et al. (2015) β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat. Med. 21 932-7 PubMed GONUTS page

[PMID:10912502-3] 3.0 ^3.1 Bard, J et al. (2000) Effect of B2m gene disruption on MHC-determined odortypes. Immunogenetics 51 514-8 PubMed GONUTS page

[PMID:24006456-4] 4.0 ^4.1 Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:9531620-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Santos, M et al. (1998) Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice. Blood 91 3059-65 PubMed GONUTS page

[PMID:11113132-6] 6.0 ^6.1 Pigeon, C et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 7811-9 PubMed GONUTS page

[PMID:16920948-7] 7.0 ^7.1 ^7.2 Kajikawa, M et al. (2006) MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression. J. Immunol. 177 3108-15 PubMed GONUTS page

[PMID:18776904-8] 8.0 ^8.1 Wang, L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. Immunol. 9 1122-30 PubMed GONUTS page

[PMID:20018625-9] 9.0 ^9.1 Escande-Beillard, N et al. (2010) Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J. Immunol. 184 816-23 PubMed GONUTS page

[PMID:1538753-10] 10.0 ^10.1 Attaya, M et al. (1992) Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature 355 647-9 PubMed GONUTS page

[PMID:16299293-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Ugrinovic, S et al. (2005) H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium. Infect. Immun. 73 8002-8 PubMed GONUTS page

[PMID:2685607-12] 12.0 ^12.1 Zijlstra, M et al. (1989) Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342 435-8 PubMed GONUTS page

[PMID:14735325-13] Lilić, M et al. (2004) Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain. Immunogenetics 55 740-7 PubMed GONUTS page

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MOUSE:B2MG

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