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MOUSE:ANK1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ank1 (synonyms: Ank-1)
Protein Name(s) Ankyrin-1

ANK-1 Erythrocyte ankyrin

External Links
UniProt Q02357
EMBL M84756
X69063
X69064
U73972
AK134267
AK147278
AK147597
AK158131
BC061219
U76758
U76758
U76758
CCDS CCDS22187.1
CCDS52523.1
CCDS72099.1
CCDS72100.1
CCDS72101.1
PIR I49502
S37771
S37772
RefSeq NP_001104253.1
NP_001264209.1
NP_001264210.1
NP_001264215.1
NP_001264218.1
NP_112435.2
XP_006509068.1
XP_006509069.1
UniGene Mm.334444
ProteinModelPortal Q02357
SMR Q02357
IntAct Q02357
MINT MINT-255055
PhosphoSite Q02357
MaxQB Q02357
PaxDb Q02357
PRIDE Q02357
Ensembl ENSMUST00000033947
ENSMUST00000110688
ENSMUST00000121075
ENSMUST00000121802
GeneID 11733
KEGG mmu:11733
UCSC uc009lee.2
uc009lef.2
uc009lel.1
uc009lem.1
CTD 286
MGI MGI:88024
eggNOG COG0666
GeneTree ENSGT00760000118950
HOVERGEN HBG004234
InParanoid Q02357
KO K10380
OrthoDB EOG7P02H2
TreeFam TF351263
Reactome REACT_198267
REACT_230679
REACT_235102
REACT_244931
NextBio 279431
PRO PR:Q02357
Proteomes UP000000589
Bgee Q02357
CleanEx MM_ANK1
ExpressionAtlas Q02357
Genevestigator Q02357
GO GO:0030673
GO:0030863
GO:0031430
GO:0016020
GO:0005634
GO:0045211
GO:0042383
GO:0016529
GO:0014731
GO:0030018
GO:0006888
GO:0048821
GO:0055072
GO:0015672
GO:0006779
GO:0010638
GO:0072661
GO:0007165
Gene3D 1.10.533.10
1.25.40.20
InterPro IPR002110
IPR020683
IPR011029
IPR000488
IPR000906
Pfam PF00023
PF12796
PF00531
PF00791
PRINTS PR01415
SMART SM00248
SM00005
SM00218
SUPFAM SSF47986
SSF48403
PROSITE PS50297
PS50088
PS50017
PS51145

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0072659

protein localization to plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001191120
UniProtKB:F1PRC8
UniProtKB:P16157
UniProtKB:Q01484
UniProtKB:Q12955

P

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001191120
UniProtKB:Q01484

F

Seeded From UniProt

complete

part_of

GO:0043194

axon initial segment

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001191120
UniProtKB:Q12955

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88024
PANTHER:PTN001191120

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072659

protein localization to plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0055072

iron ion homeostasis

PMID:23390527[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5502651

P

Seeded From UniProt

complete

enables

GO:0051117

ATPase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048821

erythrocyte development

PMID:23390527[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5502651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048821

erythrocyte development

PMID:2139228[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856298

P

results_in_development_of:(CL:0000232)

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0031672

A band

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0031430

M band

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0030863

cortical cytoskeleton

PMID:18723693[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000232)

Seeded From UniProt

complete

part_of

GO:0030673

axolemma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

enables

GO:0030507

spectrin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

F

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

F

Seeded From UniProt

complete

part_of

GO:0016529

sarcoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:18723693[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000232)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015672

monovalent inorganic cation transport

PMID:7492791[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856298

P

Seeded From UniProt

complete

part_of

GO:0014731

spectrin-associated cytoskeleton

PMID:6234993[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856298

C

part_of:(CL:0000232)

Seeded From UniProt

complete

part_of

GO:0014731

spectrin-associated cytoskeleton

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010638

positive regulation of organelle organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

P

Seeded From UniProt

complete

part_of

GO:0009898

cytoplasmic side of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

C

Seeded From UniProt

complete

enables

GO:0008093

cytoskeletal adaptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006779

porphyrin-containing compound biosynthetic process

PMID:658175[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856298

P

occurs_in:(CL:0000232)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16157

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1309620

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000488

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0016529

sarcoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0703
UniProtKB-SubCell:SL-0239

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 Yuki, KE et al. (2013) Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. PLoS ONE 8 e55331 PubMed GONUTS page
  3. ↑ White, RA et al. (1990) Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin. Proc. Natl. Acad. Sci. U.S.A. 87 3117-21 PubMed GONUTS page
  4. ↑ 4.0 4.1 Robledo, RF et al. (2008) Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood 112 4298-307 PubMed GONUTS page
  5. ↑ Joiner, CH et al. (1995) Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons. Blood 86 4307-14 PubMed GONUTS page
  6. ↑ Bodine, DM 4th et al. (1984) Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes. Cell 37 721-9 PubMed GONUTS page
  7. ↑ Sassa, S & Bernstein, SE (1978) Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp. Hematol. 6 479-87 PubMed GONUTS page
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