MOUSE:ANGI

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ang (synonyms: Ang1, Rnase5, Rnase5a)
Protein Name(s)	Angiogenin Angiogenin-1 Ribonuclease 5 RNase 5
External Links
UniProt	P21570
EMBL	U22516 BC055355
CCDS	CCDS27034.1
PIR	A35932
RefSeq	NP_001155203.1 NP_031473.1
UniGene	Mm.202665
PDB	2BWK 2BWL
PDBsum	2BWK 2BWL
ProteinModelPortal	P21570
SMR	P21570
STRING	10090.ENSMUSP00000067434
PhosphoSite	P21570
PaxDb	P21570
PRIDE	P21570
Ensembl	ENSMUST00000069011 ENSMUST00000171688
GeneID	11727
KEGG	mmu:11727
UCSC	uc007tml.2
CTD	283
MGI	MGI:88022
eggNOG	NOG283332
HOGENOM	HOG000276883
HOVERGEN	HBG008396
InParanoid	P21570
KO	K16631
OMA	PCKYRAT
OrthoDB	EOG7J1826
PhylomeDB	P21570
TreeFam	TF333393
Reactome	REACT_211860
ChiTaRS	Ang
EvolutionaryTrace	P21570
NextBio	279409
PRO	PR:P21570
Proteomes	UP000000589
Bgee	P21570
ExpressionAtlas	P21570
Genevestigator	P21570
GO	GO:0032311 GO:0005605 GO:0005576 GO:0005615 GO:0030426 GO:0043025 GO:0005730 GO:0005634 GO:0003779 GO:0005507 GO:0003677 GO:0004519 GO:0008201 GO:0005102 GO:0004540 GO:0003723 GO:0030041 GO:0032431 GO:0007202 GO:0001525 GO:0030154 GO:0007417 GO:0006651 GO:0048662 GO:0017148 GO:0001938 GO:0050714 GO:0001666 GO:0090501 GO:0009303
Gene3D	3.10.130.10
InterPro	IPR001427 IPR023411 IPR023412
PANTHER	PTHR11437
Pfam	PF00074
PRINTS	PR00794
ProDom	PD000535
SMART	SM00092
SUPFAM	SSF54076
PROSITE	PS00127

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:17468498^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032431	activation of phospholipase A2 activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
part_of	GO:0032311	angiogenin-PRI complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:17468498^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030041	actin filament polymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10152	P	Seeded From UniProt	complete
involved_in	GO:0009303	rRNA transcription	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:17468498^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007202	activation of phospholipase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
involved_in	GO:0006651	diacylglycerol biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5WRG2	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104984 MGI:MGI:1201793 MGI:MGI:1890463 MGI:MGI:1890464 MGI:MGI:2656551 MGI:MGI:88022 PANTHER:PTN001350296 UniProtKB:P00669 UniProtKB:P03950 UniProtKB:P07998 UniProtKB:P10152 UniProtKB:P10153 UniProtKB:P27043 UniProtKB:P30374 UniProtKB:Q93091 UniProtKB:Q9H1E1	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050714	positive regulation of protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032431	activation of phospholipase A2 activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
part_of	GO:0032311	angiogenin-PRI complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032148	activation of protein kinase B activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009725	response to hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009303	rRNA transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007202	activation of phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006651	diacylglycerol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:8448182^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:23170778^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:8448182^[3]	ECO:0000305	curator inference used in manual assertion	GO:0004540	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03950	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001427	F	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12548285^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:12548285^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:12548285^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:12548285^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	PMID:12548285^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	PMID:12548285^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-211119	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0652	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Subramanian, V & Feng, Y (2007) A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis. Hum. Mol. Genet. 16 1445-53 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Bond, MD et al. (1993) Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim. Biophys. Acta 1162 177-86 PubMed GONUTS page
↑ Iyer, S et al. (2013) Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues. FEBS J. 280 302-18 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Hooper, LV et al. (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4 269-73 PubMed GONUTS page

[PMID:17468498-1] 1.0 ^1.1 ^1.2 Subramanian, V & Feng, Y (2007) A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis. Hum. Mol. Genet. 16 1445-53 PubMed GONUTS page

[PMID:21873635-2] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8448182-3] 3.0 ^3.1 Bond, MD et al. (1993) Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim. Biophys. Acta 1162 177-86 PubMed GONUTS page

[PMID:23170778-4] Iyer, S et al. (2013) Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues. FEBS J. 280 302-18 PubMed GONUTS page

[PMID:12548285-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Hooper, LV et al. (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4 269-73 PubMed GONUTS page

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MOUSE:ANGI

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Notes

References

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