MOUSE:ADA10

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Adam10 (synonyms: Kuz, Madm)
Protein Name(s)	Disintegrin and metalloproteinase domain-containing protein 10 ADAM 10 Kuzbanian protein homolog Mammalian disintegrin-metalloprotease
External Links
UniProt	O35598
EMBL	AF011379 CT025701 AC091263 AC160636 CH466522 AK036883 AK036599
CCDS	CCDS23323.1
RefSeq	NP_031425.2
UniGene	Mm.3037
ProteinModelPortal	O35598
SMR	O35598
BioGrid	197960
IntAct	O35598
MINT	MINT-4086890
STRING	10090.ENSMUSP00000063839
MEROPS	M12.210
PhosphoSite	O35598
MaxQB	O35598
PaxDb	O35598
PRIDE	O35598
DNASU	11487
Ensembl	ENSMUST00000067880
GeneID	11487
KEGG	mmu:11487
UCSC	uc009qor.1
CTD	102
MGI	MGI:109548
eggNOG	NOG271989
GeneTree	ENSGT00670000097974
HOGENOM	HOG000008148
HOVERGEN	HBG050455
InParanoid	O35598
KO	K06704
OMA	HEDDIKY
OrthoDB	EOG7SBNNQ
TreeFam	TF352021
Reactome	REACT_196589 REACT_196591 REACT_196638 REACT_196643 REACT_199052 REACT_199055 REACT_199384 REACT_199404 REACT_199411 REACT_199413 REACT_242976 REACT_243590
NextBio	278848
PRO	PR:O35598
Proteomes	UP000000589
Bgee	O35598
CleanEx	MM_ADAM10
ExpressionAtlas	O35598
Genevestigator	O35598
GO	GO:0009986 GO:0005737 GO:0070062 GO:0005794 GO:0005798 GO:0016021 GO:0005634 GO:0097038 GO:0005886 GO:0014069 GO:0097197 GO:0004175 GO:0004222 GO:0008237 GO:0042803 GO:0019901 GO:0042169 GO:0008270 GO:0051089 GO:0001701 GO:0006509 GO:0042117 GO:0007162 GO:0007220 GO:0007219 GO:0006913 GO:0051088 GO:0030307 GO:0008284 GO:0010820 GO:0006468 GO:0034612
Gene3D	3.40.390.10 4.10.70.10
InterPro	IPR027053 IPR001762 IPR024079 IPR001590 IPR002870
PANTHER	PTHR11905:SF113
Pfam	PF00200 PF01562
SMART	SM00050
SUPFAM	SSF57552
PROSITE	PS50215 PS50214 PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:17245433^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:17245433^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:14761956^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:12176995^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35598	F		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:12176995^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12176995^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:12354787^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	PMID:12354787^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:12354787^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	PMID:12176995^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12176995^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12176995^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12176995^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14672	F		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	PMID:12354787^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:21123580^[8]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:21123580^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21123580^[8]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21123580^[8]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21123580^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:21123580^[8]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:21123580^[8]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:21123580^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
part_of	GO:0097197	tetraspanin-enriched microdomain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051089	constitutive protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042117	monocyte activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034612	response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034205	amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:20383322^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17301176^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32845) part_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010820	positive regulation of T cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007162	negative regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	C		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14672	F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2032	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:12794186^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:104659)	Seeded From UniProt	complete
part_of	GO:0097197	tetraspanin-enriched microdomain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	C		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	C		Seeded From UniProt	complete
involved_in	GO:0051089	constitutive protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0042117	monocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0010820	positive regulation of T cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	F		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	P		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14672 ensembl:ENSP00000260408	F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
involved_in	GO:0097327	response to antineoplastic agent	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q10743 ensembl:ENSRNOP00000073306	F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001590 InterPro:IPR027053	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001590	P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027053	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027053	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024079 InterPro:IPR034025	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-209162 Reactome:R-MMU-9604278 Reactome:R-MMU-3928661 Reactome:R-MMU-2193065 Reactome:R-MMU-179883	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	Reactome:R-NUL-209162 Reactome:R-MMU-9604278 Reactome:R-MMU-2193065	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0729	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ ^3.0 ^3.1 Li, N et al. (2007) Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 26 494-504 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ Naus, S et al. (2004) Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J. Biol. Chem. 279 16083-90 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Lim, R et al. (2002) MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. J. Biol. Chem. 277 40997-1008 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Hartmann, D et al. (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11 2615-24 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Malinverno, M et al. (2010) Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. J. Neurosci. 30 16343-55 PubMed GONUTS page
↑ Dietrich, MF et al. (2010) Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS ONE 5 e9960 PubMed GONUTS page
↑ Marcello, E et al. (2007) Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. J. Neurosci. 27 1682-91 PubMed GONUTS page
↑ Six, E et al. (2003) The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc. Natl. Acad. Sci. U.S.A. 100 7638-43 PubMed GONUTS page

[PMID:28071719-1] Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-2] Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:17245433-3] 3.0 ^3.1 Li, N et al. (2007) Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 26 494-504 PubMed GONUTS page

[PMID:24006456-4] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:14761956-5] Naus, S et al. (2004) Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J. Biol. Chem. 279 16083-90 PubMed GONUTS page

[PMID:12176995-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Lim, R et al. (2002) MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. J. Biol. Chem. 277 40997-1008 PubMed GONUTS page

[PMID:12354787-7] 7.0 ^7.1 ^7.2 ^7.3 Hartmann, D et al. (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11 2615-24 PubMed GONUTS page

[PMID:21123580-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Malinverno, M et al. (2010) Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. J. Neurosci. 30 16343-55 PubMed GONUTS page

[PMID:20383322-9] Dietrich, MF et al. (2010) Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS ONE 5 e9960 PubMed GONUTS page

[PMID:17301176-10] Marcello, E et al. (2007) Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. J. Neurosci. 27 1682-91 PubMed GONUTS page

[PMID:12794186-11] Six, E et al. (2003) The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc. Natl. Acad. Sci. U.S.A. 100 7638-43 PubMed GONUTS page

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