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MOUSE:ACSL1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Acsl1 (synonyms: Acsl2, Facl2) | |
| Protein Name(s) | Long-chain-fatty-acid--CoA ligase 1
Long-chain acyl-CoA synthetase 1 LACS 1 | |
| External Links | ||
| UniProt | P41216 | |
| EMBL | U15977 AK004897 AK145900 AK149406 AK152772 AK153050 AK161189 AK168078 BC056644 | |
| CCDS | CCDS22291.1 | |
| RefSeq | NP_001289092.1 NP_032007.2 XP_006509327.1 XP_006509328.1 XP_006509329.1 | |
| UniGene | Mm.210323 | |
| ProteinModelPortal | P41216 | |
| SMR | P41216 | |
| IntAct | P41216 | |
| MINT | MINT-1859502 | |
| PhosphoSite | P41216 | |
| MaxQB | P41216 | |
| PaxDb | P41216 | |
| PRIDE | P41216 | |
| Ensembl | ENSMUST00000034046 ENSMUST00000110372 | |
| GeneID | 14081 | |
| KEGG | mmu:14081 | |
| UCSC | uc009lqe.1 | |
| CTD | 2180 | |
| MGI | MGI:102797 | |
| eggNOG | COG1022 | |
| GeneTree | ENSGT00690000101725 | |
| HOGENOM | HOG000159459 | |
| HOVERGEN | HBG050452 | |
| InParanoid | P41216 | |
| KO | K01897 | |
| OMA | VEVAXNG | |
| OrthoDB | EOG71CFKN | |
| TreeFam | TF313877 | |
| BRENDA | 6.2.1.3 | |
| Reactome | REACT_196530 REACT_196541 REACT_198602 REACT_252780 | |
| ChiTaRS | Acsl1 | |
| NextBio | 285092 | |
| PRO | PR:P41216 | |
| Proteomes | UP000000589 | |
| Bgee | P41216 | |
| CleanEx | MM_ACSL1 | |
| ExpressionAtlas | P41216 | |
| Genevestigator | P41216 | |
| GO | GO:0005789 GO:0016021 GO:0005741 GO:0005739 GO:0005778 GO:0005886 GO:0005524 GO:0004467 GO:0033211 GO:0008610 GO:0044539 GO:0071902 GO:0042493 GO:0007584 GO:0034201 GO:0014070 GO:0006641 GO:0042178 | |
| InterPro | IPR020845 IPR000873 | |
| Pfam | PF00501 | |
| PROSITE | PS00455 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0044539 |
long-chain fatty acid import into cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042178 |
xenobiotic catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035338 |
long-chain fatty-acyl-CoA biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0033211 |
adiponectin-activated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019432 |
triglyceride biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0015908 |
fatty acid transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010033 |
response to organic substance |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008610 |
lipid biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006631 |
fatty acid metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005778 |
peroxisomal membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)|part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004467 |
long-chain fatty acid-CoA ligase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004467 |
long-chain fatty acid-CoA ligase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2015 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001676 |
long-chain fatty acid metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042178 |
xenobiotic catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035338 |
long-chain fatty-acyl-CoA biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034201 |
response to oleic acid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019432 |
triglyceride biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015908 |
fatty acid transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010033 |
response to organic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007584 |
response to nutrient |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005778 |
peroxisomal membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004467 |
long-chain fatty acid-CoA ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18163 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044539 |
long-chain fatty acid import into cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P33121 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008610 |
lipid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P33121 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P33121 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004467 |
long-chain fatty acid-CoA ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P33121 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001676 |
long-chain fatty acid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P33121 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102391 |
decanoate-CoA ligase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003996 |
acyl-CoA ligase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004467 |
long-chain fatty acid-CoA ligase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005777 |
peroxisome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005778 |
peroxisomal membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031090 |
organelle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ellis, JM et al. (2010) Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab. 12 53-64 PubMed GONUTS page
- ↑ 2.0 2.1 Liu, Q et al. (2010) Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio. FASEB J. 24 4229-39 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
a
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g
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- GO:0016874 ! ligase activity
- GO:0008610 ! lipid biosynthetic process
- GO:0006629 ! lipid metabolic process
- GO:0044539 ! long-chain fatty acid import into cell
- GO:0035338 ! long-chain fatty-acyl-CoA biosynthetic process
- GO:0001676 ! long-chain fatty acid metabolic process
- GO:0004467 ! long-chain fatty acid-CoA ligase activity
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p
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