MOUSE:ACHA4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Chrna4 (synonyms: Acra4)
Protein Name(s)	Neuronal acetylcholine receptor subunit alpha-4
External Links
UniProt	O70174
EMBL	AF225912 AK034228 AK083157 BC053013 AB010002 AF325347
CCDS	CCDS17192.1
RefSeq	NP_056545.3
UniGene	Mm.252369
ProteinModelPortal	O70174
SMR	O70174
BioGrid	197932
DIP	DIP-48731N
ChEMBL	CHEMBL4457
GuidetoPHARMACOLOGY	465
PhosphoSite	O70174
MaxQB	O70174
PaxDb	O70174
PRIDE	O70174
Ensembl	ENSMUST00000067120
GeneID	11438
KEGG	mmu:11438
UCSC	uc008okq.1
CTD	1137
MGI	MGI:87888
eggNOG	NOG290206
HOGENOM	HOG000006756
HOVERGEN	HBG003756
InParanoid	O70174
KO	K04806
PhylomeDB	O70174
TreeFam	TF315605
Reactome	REACT_198583 REACT_198585 REACT_198593
NextBio	278736
PRO	PR:O70174
Proteomes	UP000000589
Bgee	O70174
ExpressionAtlas	O70174
Genevestigator	O70174
GO	GO:0005892 GO:0030054 GO:0009897 GO:0016020 GO:0005886 GO:0045211 GO:0015464 GO:0004889 GO:0005216 GO:0001508 GO:0042113 GO:0035095 GO:0006816 GO:0098655 GO:0050890 GO:0006281 GO:0035640 GO:0034220 GO:0007626 GO:0051899 GO:0050877 GO:0014059 GO:0060080 GO:0042391 GO:0007585 GO:0001666 GO:0035094 GO:0006979 GO:0019233 GO:0007271
Gene3D	1.20.120.370 2.70.170.10
InterPro	IPR027361 IPR006202 IPR006201 IPR006029 IPR018000 IPR002394
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00254 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:12944511^[1]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098691) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:12944511^[1]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098691) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:24607281^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:29114204^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098691) part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:29114204^[3]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(GO:0098691) part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:24607281^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:12944511^[1]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:29114204^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:29114204^[3]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:12944511^[1]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P		Seeded From UniProt	complete
contributes_to	GO:0042166	acetylcholine binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 PANTHER:PTN002498457 RGD:2346 RGD:2347 RGD:621544 ZFIN:ZDB-GENE-980526-137	F		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 MGI:MGI:87889 PANTHER:PTN002498457 UniProtKB:P43681 ZFIN:ZDB-GENE-090505-3	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P		Seeded From UniProt	complete
contributes_to	GO:0015464	acetylcholine receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87888 PANTHER:PTN002498457 UniProtKB:P30532 UniProtKB:P43681 ZFIN:ZDB-GENE-980526-137	F		Seeded From UniProt	complete
involved_in	GO:0007274	neuromuscular synaptic transmission	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002498457 UniProtKB:P02708 ZFIN:ZDB-GENE-980526-137	P		Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN002498457 RGD:2346	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87888 MGI:MGI:87889 PANTHER:PTN002498457 RGD:2346 RGD:2347 RGD:621544 RGD:69277 UniProtKB:P43681 ZFIN:ZDB-GENE-090505-3 ZFIN:ZDB-GENE-980526-137	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C		Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903048	regulation of acetylcholine-gated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0095500	acetylcholine receptor signaling pathway	PMID:26276394^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060080	inhibitory postsynaptic potential	PMID:17146052^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700204 MGI:MGI:3700205	P	occurs_in:(EMAPA:35256) occurs_in:(CL:0000598)\|occurs_in:(EMAPA:35257) occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:15741168^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:12944511^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P	occurs_in:(EMAPA:17549) occurs_in:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:11226318^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158758	P	occurs_in:(EMAPA:16974) occurs_in:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:11222635^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P	occurs_in:(EMAPA:16974) occurs_in:(CL:0000700)\|occurs_in:(EMAPA:16974) occurs_in:(CL:0000617)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050877	nervous system process	PMID:17146052^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700204 MGI:MGI:3700205	P	has_participant:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050877	nervous system process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:15569257^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	P		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042113	B cell activation	PMID:15963492^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035640	exploration behavior	PMID:10964949^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888964	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035095	behavioral response to nicotine	PMID:15528443^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3511287	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035095	behavioral response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	PMID:15741168^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	PMID:10235262^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	PMID:12871652^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033603	positive regulation of dopamine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:15741168^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	F		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:15569257^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	F		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:15528443^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3511287	F	occurs_in:(EMAPA:32870)\|occurs_in:(EMAPA:32869)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:12130686^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:11222635^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	F	occurs_in:(EMAPA:16974) occurs_in:(CL:0000700)\|occurs_in:(EMAPA:16974) occurs_in:(CL:0000617)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	F		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:10235262^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19246390^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11906696^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	F		Seeded From UniProt	complete
contributes_to	GO:0015464	acetylcholine receptor activity	PMID:12871652^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014059	regulation of dopamine secretion	PMID:12944511^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P	regulates_o_occurs_in:(EMAPA:17549) regulates_o_occurs_in:(CL:0000700)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15963492^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18767) part_of:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:11226318^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158758	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007585	respiratory gaseous exchange	PMID:21606356^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:16853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007271	synaptic transmission, cholinergic	PMID:11226318^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158758	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007271	synaptic transmission, cholinergic	PMID:11906696^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007271	synaptic transmission, cholinergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:15569257^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:17434683^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3KP94	C	part_of:(EMAPA:32845)	Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:26276394^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:12944511^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17549)	Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:12871652^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	C		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2346	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:26276394^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15741168^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:11906696^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001508	action potential	PMID:10235262^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926251	P	occurs_in:(EMAPA:17540) regulates_o_occurs_in:(CL:0000117)\|occurs_in(EMAPA:35720) regulates_o_occurs_in:(CL:0000850)	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0050890	cognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
involved_in	GO:0035095	behavioral response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	F		Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:10964949^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:10964949^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Champtiaux, N et al. (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J. Neurosci. 23 7820-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Garção, P et al. (2014) Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neurosci. Lett. 566 106-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Tarren, JR et al. (2017) Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala. Front Mol Neurosci 10 338 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wu, M et al. (2015) Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. J. Biol. Chem. 290 24509-18 PubMed GONUTS page
↑ ^6.0 ^6.1 Klaassen, A et al. (2006) Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc. Natl. Acad. Sci. U.S.A. 103 19152-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Darsow, T et al. (2005) Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors. J. Biol. Chem. 280 18311-20 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Labarca, C et al. (2001) Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc. Natl. Acad. Sci. U.S.A. 98 2786-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Klink, R et al. (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21 1452-63 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Karadsheh, MS et al. (2004) Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells. J. Neurochem. 91 1138-50 PubMed GONUTS page
↑ ^11.0 ^11.1 Skok, M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur. J. Pharmacol. 517 246-51 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Ross, SA et al. (2000) Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J. Neurosci. 20 6431-41 PubMed GONUTS page
↑ ^13.0 ^13.1 Tapper, AR et al. (2004) Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science 306 1029-32 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Marubio, LM et al. (1999) Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398 805-10 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Kim, H et al. (2003) The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs. Neuropharmacology 45 345-54 PubMed GONUTS page
↑ Dobelis, P et al. (2002) A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. Mol. Pharmacol. 62 334-42 PubMed GONUTS page
↑ Tekinay, AB et al. (2009) A role for LYNX2 in anxiety-related behavior. Proc. Natl. Acad. Sci. U.S.A. 106 4477-82 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Ibañez-Tallon, I et al. (2002) Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 33 893-903 PubMed GONUTS page
↑ Krasteva, G et al. (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc. Natl. Acad. Sci. U.S.A. 108 9478-83 PubMed GONUTS page
↑ Yu, WF et al. (2007) Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice. Neuroscience 146 1618-28 PubMed GONUTS page

[PMID:12944511-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Champtiaux, N et al. (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J. Neurosci. 23 7820-9 PubMed GONUTS page

[PMID:24607281-2] 2.0 ^2.1 Garção, P et al. (2014) Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neurosci. Lett. 566 106-10 PubMed GONUTS page

[PMID:29114204-3] 3.0 ^3.1 ^3.2 ^3.3 Tarren, JR et al. (2017) Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala. Front Mol Neurosci 10 338 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26276394-5] 5.0 ^5.1 ^5.2 Wu, M et al. (2015) Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. J. Biol. Chem. 290 24509-18 PubMed GONUTS page

[PMID:17146052-6] 6.0 ^6.1 Klaassen, A et al. (2006) Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc. Natl. Acad. Sci. U.S.A. 103 19152-7 PubMed GONUTS page

[PMID:15741168-7] 7.0 ^7.1 ^7.2 ^7.3 Darsow, T et al. (2005) Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors. J. Biol. Chem. 280 18311-20 PubMed GONUTS page

[PMID:11226318-8] 8.0 ^8.1 ^8.2 Labarca, C et al. (2001) Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc. Natl. Acad. Sci. U.S.A. 98 2786-91 PubMed GONUTS page

[PMID:11222635-9] 9.0 ^9.1 Klink, R et al. (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21 1452-63 PubMed GONUTS page

[PMID:15569257-10] 10.0 ^10.1 ^10.2 Karadsheh, MS et al. (2004) Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells. J. Neurochem. 91 1138-50 PubMed GONUTS page

[PMID:15963492-11] 11.0 ^11.1 Skok, M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur. J. Pharmacol. 517 246-51 PubMed GONUTS page

[PMID:10964949-12] 12.0 ^12.1 ^12.2 Ross, SA et al. (2000) Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J. Neurosci. 20 6431-41 PubMed GONUTS page

[PMID:15528443-13] 13.0 ^13.1 Tapper, AR et al. (2004) Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science 306 1029-32 PubMed GONUTS page

[PMID:10235262-14] 14.0 ^14.1 ^14.2 Marubio, LM et al. (1999) Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398 805-10 PubMed GONUTS page

[PMID:12871652-15] 15.0 ^15.1 ^15.2 Kim, H et al. (2003) The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs. Neuropharmacology 45 345-54 PubMed GONUTS page

[PMID:12130686-16] Dobelis, P et al. (2002) A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. Mol. Pharmacol. 62 334-42 PubMed GONUTS page

[PMID:19246390-17] Tekinay, AB et al. (2009) A role for LYNX2 in anxiety-related behavior. Proc. Natl. Acad. Sci. U.S.A. 106 4477-82 PubMed GONUTS page

[PMID:11906696-18] 18.0 ^18.1 ^18.2 Ibañez-Tallon, I et al. (2002) Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 33 893-903 PubMed GONUTS page

[PMID:21606356-19] Krasteva, G et al. (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc. Natl. Acad. Sci. U.S.A. 108 9478-83 PubMed GONUTS page

[PMID:17434683-20] Yu, WF et al. (2007) Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice. Neuroscience 146 1618-28 PubMed GONUTS page

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