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MOUSE:ABI1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Abi1 (synonyms: Ssh3bp1) | |
| Protein Name(s) | Abl interactor 1
Abelson interactor 1 Abi-1 Ablphilin-1 Eps8 SH3 domain-binding protein Eps8-binding protein Spectrin SH3 domain-binding protein 1 e3B1 | |
| External Links | ||
| UniProt | Q8CBW3 | |
| EMBL | AF420251 AY033645 AK034476 AK152061 AK152184 AK151026 BC004657 U17698 | |
| CCDS | CCDS38058.1 CCDS38059.1 CCDS38060.1 CCDS38061.1 CCDS50513.1 | |
| RefSeq | NP_001070658.1 NP_001070660.1 NP_001070661.1 NP_031406.2 | |
| UniGene | Mm.205647 Mm.249752 | |
| ProteinModelPortal | Q8CBW3 | |
| SMR | Q8CBW3 | |
| BioGrid | 197905 | |
| DIP | DIP-29534N | |
| IntAct | Q8CBW3 | |
| MINT | MINT-128698 | |
| PhosphoSite | Q8CBW3 | |
| MaxQB | Q8CBW3 | |
| PaxDb | Q8CBW3 | |
| PRIDE | Q8CBW3 | |
| DNASU | 11308 | |
| Ensembl | ENSMUST00000114544 ENSMUST00000123948 ENSMUST00000126112 ENSMUST00000140164 ENSMUST00000149719 | |
| GeneID | 11308 | |
| KEGG | mmu:11308 | |
| UCSC | uc008ins.1 | |
| CTD | 10006 | |
| MGI | MGI:104913 | |
| eggNOG | NOG262939 | |
| GeneTree | ENSGT00390000003756 | |
| HOGENOM | HOG000293213 | |
| HOVERGEN | HBG050446 | |
| InParanoid | Q8CBW3 | |
| OMA | MPMFDDS | |
| OrthoDB | EOG7J17ZT | |
| PhylomeDB | Q8CBW3 | |
| TreeFam | TF314303 | |
| Reactome | REACT_198374 REACT_257088 | |
| ChiTaRS | Abi1 | |
| NextBio | 278608 | |
| PRO | PR:Q8CBW3 | |
| Proteomes | UP000000589 | |
| Bgee | Q8CBW3 | |
| CleanEx | MM_ABI1 | |
| ExpressionAtlas | Q8CBW3 | |
| Genevestigator | Q8CBW3 | |
| GO | GO:0030054 GO:0031252 GO:0070062 GO:0030175 GO:0030426 GO:0005622 GO:0030027 GO:0043005 GO:0005634 GO:0014069 GO:0045211 GO:0031209 GO:0030296 GO:0006928 GO:0009987 GO:0072673 GO:0035855 GO:0018108 GO:0061098 GO:0001756 | |
| InterPro | IPR028457 IPR028456 IPR012849 IPR001452 IPR000727 | |
| PANTHER | PTHR10460 PTHR10460:SF2 | |
| Pfam | PF07815 PF00018 | |
| PRINTS | PR00452 | |
| SMART | SM00326 | |
| SUPFAM | SSF50044 | |
| PROSITE | PS50002 PS50192 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104913 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000048906 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0099527 |
postsynapse to nucleus signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621008 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621008 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0072673 |
lamellipodium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000556) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048813 |
dendrite morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035855 |
megakaryocyte development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
results_in_development_of:(CL:0000556) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032433 |
filopodium tip |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031252 |
cell leading edge |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031252 |
cell leading edge |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031209 |
SCAR complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030296 |
protein tyrosine kinase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621008 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621008 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001756 |
somitogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3578145 |
P |
has_participant:(EMAPA:16172)|has_participant:(EMAPA:16184) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0030296 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030296 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032433 |
filopodium tip |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IZP0 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031209 |
SCAR complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IZP0 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IZP0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IZP0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8IZP0 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008154 |
actin polymerization or depolymerization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030296 |
protein tyrosine kinase activator activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030175 |
filopodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Eto, K et al. (2007) The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110 3637-47 PubMed GONUTS page
- ↑ Jia, JM et al. (2014) The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. J. Neurosci. 34 13725-36 PubMed GONUTS page
- ↑ Millius, A et al. (2009) Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr. Biol. 19 253-9 PubMed GONUTS page
- ↑ Rakeman, AS & Anderson, KV (2006) Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development 133 3075-83 PubMed GONUTS page
- ↑ 7.0 7.1 Tani, K et al. (2003) Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase. J. Biol. Chem. 278 21685-92 PubMed GONUTS page
- ↑ 8.0 8.1 Hirao, N et al. (2006) NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. FEBS Lett. 580 6464-70 PubMed GONUTS page
- ↑ García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
c
m
p
- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0005886 ! plasma membrane
- GO:0061098 ! positive regulation of protein tyrosine kinase activity
- GO:0099527 ! postsynapse to nucleus signaling pathway
- GO:0045211 ! postsynaptic membrane
- GO:0014069 ! postsynaptic density
- GO:0030296 ! protein tyrosine kinase activator activity
r
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