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PMID:17101133
| Citation |
Hirao, N, Sato, S, Gotoh, T, Maruoka, M, Suzuki, J, Matsuda, S, Shishido, T and Tani, K (2006) NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. FEBS Lett. 580:6464-70 |
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| Abstract |
Abl interactor (Abi) was identified as an Abl tyrosine kinase-binding protein and subsequently shown to be a component of the macromolecular Abi/WAVE complex, which is a key regulator of Rac-dependent actin polymerization. Previous studies showed that Abi-1 promotes c-Abl-mediated phosphorylation of Mammalian Enabled (Mena) and WAVE2. In addition to Abi-1, mammals possess Abi-2 and NESH (Abi-3). In this study, we compared the three Abi proteins in terms of the promotion of c-Abl-mediated phosphorylation and the formation of Abi/WAVE complex. Although Abi-2, like Abi-1, promoted the c-Abl-mediated phosphorylation of Mena and WAVE2, NESH (Abi-3) had no such effect. This difference was likely due to their binding abilities as to c-Abl. Immunoprecipitation revealed that NESH (Abi-3) is present in the Abi/WAVE complex. Our results suggest that NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl. |
| Links |
PubMed Online version:10.1016/j.febslet.2006.10.065 |
| Keywords |
Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Animals; COS Cells; Cercopithecus aethiops; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/metabolism; Gene Expression Regulation/physiology; Humans; Mice; Multiprotein Complexes/genetics; Multiprotein Complexes/metabolism; Phosphorylation; Protein Processing, Post-Translational/physiology; Proto-Oncogene Proteins c-abl/genetics; Proto-Oncogene Proteins c-abl/metabolism; Wiskott-Aldrich Syndrome Protein Family/genetics; Wiskott-Aldrich Syndrome Protein Family/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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