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HUMAN:ZCHC8

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ZCCHC8
Protein Name(s) Zinc finger CCHC domain-containing protein 8

TRAMP-like complex RNA-binding factor ZCCHC8

External Links
UniProt Q6NZY4
EMBL AK027702
AK074638
AL157433
AL157434
BC017704
BC065918
PIR T46929
T46930
RefSeq NP_060082.2
XP_005253638.1
XP_006719555.1
UniGene Hs.37706
ProteinModelPortal Q6NZY4
BioGrid 120739
IntAct Q6NZY4
MINT MINT-1187494
STRING 9606.ENSP00000337313
PhosphoSite Q6NZY4
DMDM 66774213
MaxQB Q6NZY4
PaxDb Q6NZY4
PRIDE Q6NZY4
Ensembl ENST00000536306
ENST00000543897
GeneID 55596
KEGG hsa:55596
UCSC uc001ucm.3
CTD 55596
GeneCards GC12M122958
H-InvDB HIX0011095
HGNC HGNC:25265
HPA HPA037483
HPA037484
neXtProt NX_Q6NZY4
PharmGKB PA134889410
eggNOG NOG242619
GeneTree ENSGT00390000011475
HOGENOM HOG000155769
HOVERGEN HBG079371
InParanoid Q6NZY4
KO K13128
OMA CEETIEQ
OrthoDB EOG7RNK09
PhylomeDB Q6NZY4
TreeFam TF321837
ChiTaRS ZCCHC8
GeneWiki ZCCHC8
GenomeRNAi 55596
NextBio 60130
PMAP-CutDB Q6NZY4
PRO PR:Q6NZY4
Proteomes UP000005640
Bgee Q6NZY4
CleanEx HS_ZCCHC8
ExpressionAtlas Q6NZY4
Genevestigator Q6NZY4
GO GO:0071013
GO:0005654
GO:0005634
GO:0044822
GO:0008270
GO:0000398
Gene3D 4.10.60.10
InterPro IPR006568
IPR001878
Pfam PF04046
PF00098
SMART SM00581
SM00343
PROSITE PS50158

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0031499

TRAMP complex

PMID:21855801[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:16263084[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|part_of

GO:0005730

nucleolus

PMID:21855801[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21855801[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071013

catalytic step 2 spliceosome

PMID:11991638[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:11991638[3]

ECO:0000305

curator inference used in manual assertion

GO:0071013

P

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001878

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001878

F

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

part_of

GO:0005681

spliceosomal complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0747

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Lubas, M et al. (2011) Interaction profiling identifies the human nuclear exosome targeting complex. Mol. Cell 43 624-37 PubMed GONUTS page
  2. Gustafson, MP et al. (2005) Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. Biochem. Biophys. Res. Commun. 338 1359-67 PubMed GONUTS page
  3. 3.0 3.1 Jurica, MS et al. (2002) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8 426-39 PubMed GONUTS page
  4. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page