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HUMAN:YBOX1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) YBX1 (synonyms: NSEP1, YB1)
Protein Name(s) Nuclease-sensitive element-binding protein 1

CCAAT-binding transcription factor I subunit A CBF-A DNA-binding protein B DBPB Enhancer factor I subunit A EFI-A Y-box transcription factor Y-box-binding protein 1 YB-1

External Links
UniProt P67809
EMBL M24070
J03827
M83234
L28809
BC002411
BC010430
BC015208
BC038384
BC065571
BC070084
BC071708
BC090038
BC098435
BC106045
CCDS CCDS470.1
PIR I39382
S34426
RefSeq NP_004550.2
UniGene Hs.473583
PDB 1H95
PDBsum 1H95
ProteinModelPortal P67809
SMR P67809
BioGrid 110959
DIP DIP-29405N
IntAct P67809
MINT MINT-5001202
STRING 9606.ENSP00000361626
PhosphoSite P67809
DMDM 54040031
MaxQB P67809
PaxDb P67809
PRIDE P67809
DNASU 4904
Ensembl ENST00000321358
GeneID 4904
KEGG hsa:4904
UCSC uc001chs.3
CTD 4904
GeneCards GC01P043148
H-InvDB HIX0037767
HIX0172381
HGNC HGNC:8014
HPA CAB005875
HPA040304
HPA057159
MIM 154030
neXtProt NX_P67809
PharmGKB PA31791
eggNOG COG1278
GeneTree ENSGT00390000009256
HOGENOM HOG000116439
HOVERGEN HBG008757
InParanoid P67809
KO K09276
OMA RRYPPYY
PhylomeDB P67809
TreeFam TF317306
Reactome REACT_467
SignaLink P67809
ChiTaRS YBX1
EvolutionaryTrace P67809
GeneWiki Y_box_binding_protein_1
GenomeRNAi 4904
NextBio 18871
PMAP-CutDB P67809
PRO PR:P67809
Proteomes UP000005640
Bgee P67809
CleanEx HS_YBX1
ExpressionAtlas P67809
Genevestigator P67809
GO GO:0070937
GO:0005737
GO:0010494
GO:0070062
GO:0071204
GO:0043231
GO:0031965
GO:0005654
GO:0005634
GO:0030529
GO:0005689
GO:0003677
GO:0003690
GO:0044822
GO:0003723
GO:0003700
GO:0003697
GO:0070934
GO:0010467
GO:0001701
GO:0000398
GO:0051154
GO:0000122
GO:0051781
GO:0006355
GO:0008380
GO:0006366
Gene3D 2.40.50.140
InterPro IPR019844
IPR011129
IPR002059
IPR012340
Pfam PF00313
PRINTS PR00050
SMART SM00357
SUPFAM SSF50249
PROSITE PS00352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0040029

regulation of gene expression, epigenetic

PMID:14738225[1]

ECO:0000315

P

Figure 3 shows a "positive nuclear YB‐1 expression in tumours showed reduced survival times when compared with patients without nuclear expression".

complete
CACAO 5864

GO:0061388

regulation of rate of cell growth

PMID:21652770[2]

ECO:0000314

P

Figure 1 shows "nuclear YB-1 expression correlates with Gleason score and AR expression in human PCa tissues."

complete
CACAO 5871

GO:0030307

positive regulation of cell growth

PMID:21652770[2]

ECO:0000314

P

Figure 3 shows "YB-1 expression and nuclear localization increased in castration-resistant CxR cells."

complete
CACAO 5873

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR002059

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q9JKB3

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24965446[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903608

protein localization to cytoplasmic stress granule

PMID:24965446[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051020

GTPase binding

PMID:24337748[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P32455

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:18809583[6]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18809583[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:18809583[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0071204

histone pre-mRNA 3'end processing complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62960

C

Seeded From UniProt

complete

part_of

GO:0070937

CRD-mediated mRNA stability complex

PMID:19029303[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070934

CRD-mediated mRNA stabilization

PMID:19029303[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[10]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:17289661[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:18335541[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:18809583[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005689

U12-type spliceosomal complex

PMID:15146077[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:19561594[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:18809583[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098761

cellular response to interleukin-7

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

P

Seeded From UniProt

complete

part_of

GO:0071204

histone pre-mRNA 3'end processing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

C

Seeded From UniProt

complete

involved_in

GO:0051154

negative regulation of striated muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

F

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62960
ensembl:ENSMUSP00000078589

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002059
InterPro:IPR011129

F

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:3174636[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:3174636[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:3174636[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:1738588[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:1738588[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:2977358[17]
PMID:8188694[18]
PMID:2977358[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion



F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-75079
Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-72139
Reactome:R-HSA-72130
Reactome:R-HSA-72127
Reactome:R-HSA-72124
Reactome:R-HSA-72107
Reactome:R-HSA-156661
Reactome:R-HSA-75083
Reactome:R-HSA-75082
Reactome:R-HSA-75081
Reactome:R-HSA-75080

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-9017817
Reactome:R-HSA-9017797

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72165
Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

Reactome:R-HSA-9017797

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Gessner, C et al. (2004) Nuclear YB-1 expression as a negative prognostic marker in nonsmall cell lung cancer. Eur. Respir. J. 23 14-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Shiota, M et al. (2011) Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression. Endocr. Relat. Cancer 18 505-17 PubMed GONUTS page
  3. ↑ 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  4. ↑ 4.0 4.1 Jefferson, M et al. (2014) Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex. J. Virol. 88 10340-53 PubMed GONUTS page
  5. ↑ Forster, F et al. (2014) Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J. Immunol. 192 771-81 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Chattopadhyay, R et al. (2008) Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol. Cell. Biol. 28 7066-80 PubMed GONUTS page
  7. ↑ 7.0 7.1 Weidensdorfer, D et al. (2009) Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA 15 104-15 PubMed GONUTS page
  8. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  9. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  10. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  11. ↑ Jønson, L et al. (2007) Molecular composition of IMP1 ribonucleoprotein granules. Mol. Cell Proteomics 6 798-811 PubMed GONUTS page
  12. ↑ Onishi, H et al. (2008) MBNL1 associates with YB-1 in cytoplasmic stress granules. J. Neurosci. Res. 86 1994-2002 PubMed GONUTS page
  13. ↑ Will, CL et al. (2004) The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA 10 929-41 PubMed GONUTS page
  14. ↑ Ray, D et al. (2009) Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat. Biotechnol. 27 667-70 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Didier, DK et al. (1988) Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proc. Natl. Acad. Sci. U.S.A. 85 7322-6 PubMed GONUTS page
  16. ↑ 16.0 16.1 Kolluri, R et al. (1992) A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif. Nucleic Acids Res. 20 111-6 PubMed GONUTS page
  17. ↑ 17.0 17.1 Sakura, H et al. (1988) Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. Gene 73 499-507 PubMed GONUTS page
  18. ↑ Horwitz, EM et al. (1994) A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. J. Biol. Chem. 269 14130-9 PubMed GONUTS page
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