HUMAN:XRCC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	XRCC1
Protein Name(s)	DNA repair protein XRCC1 X-ray repair cross-complementing protein 1
External Links
UniProt	P18887
EMBL	M36089 AF512504 CR456728 AC018758 L34079 BC023593
CCDS	CCDS12624.1
PIR	A36353
RefSeq	NP_006288.2
UniGene	Hs.98493
PDB	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC
PDBsum	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC
ProteinModelPortal	P18887
SMR	P18887
BioGrid	113349
DIP	DIP-39067N
IntAct	P18887
MINT	MINT-245471
STRING	9606.ENSP00000262887
PhosphoSite	P18887
DMDM	317373290
MaxQB	P18887
PaxDb	P18887
PRIDE	P18887
Ensembl	ENST00000262887
GeneID	7515
KEGG	hsa:7515
CTD	7515
GeneCards	GC19M044047
H-InvDB	HIX0040090
HGNC	HGNC:12828
HPA	CAB005427 HPA006717
MIM	194360
neXtProt	NX_P18887
PharmGKB	PA369
eggNOG	NOG295271
GeneTree	ENSGT00390000004140
HOVERGEN	HBG052992
InParanoid	P18887
KO	K10803
OrthoDB	EOG77WWD8
PhylomeDB	P18887
TreeFam	TF101201
Reactome	REACT_933
SignaLink	P18887
ChiTaRS	XRCC1
EvolutionaryTrace	P18887
GeneWiki	XRCC1
GenomeRNAi	7515
NextBio	29407
PRO	PR:P18887
Proteomes	UP000005640
Bgee	P18887
CleanEx	HS_XRCC1
ExpressionAtlas	P18887
Genevestigator	P18887
GO	GO:0005654 GO:0005634 GO:0003684 GO:0006284 GO:0006281 GO:0021766 GO:0042493 GO:0001666 GO:0010033 GO:0000012
Gene3D	2.60.120.260 3.40.50.10190
InterPro	IPR001357 IPR008979 IPR002706
Pfam	PF00533 PF01834
SMART	SM00292
SUPFAM	SSF49785 SSF52113
PROSITE	PS50172

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010836	negative regulation of protein ADP-ribosylation	PMID:28002403^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903518	positive regulation of single strand break repair	PMID:28002403^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:28002403^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:28002403^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0006979)	Seeded From UniProt	complete
involved_in	GO:1903518	positive regulation of single strand break repair	PMID:28002403^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09874	P		Seeded From UniProt	complete
involved_in	GO:0033194	response to hydroperoxide	PMID:28002403^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050882	voluntary musculoskeletal movement	PMID:28002403^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	PMID:28002403^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032356	oxidized DNA binding	PMID:28002403^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904877	positive regulation of DNA ligase activity	PMID:28002403^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:8532526^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49916-3	F		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146419 RGD:619823	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146419 RGD:619823 UniProtKB:P18887	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	F		Seeded From UniProt	complete
involved_in	GO:1905765	negative regulation of protection from non-homologous end joining at telomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:1903518	positive regulation of single strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
part_of	GO:0070522	ERCC4-ERCC1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	C		Seeded From UniProt	complete
involved_in	GO:0061819	telomeric DNA-containing double minutes formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:0050882	voluntary musculoskeletal movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:0021587	cerebellum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:0010836	negative regulation of protein ADP-ribosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60596 ensembl:ENSMUSP00000146105	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ESZ0 ensembl:ENSRNOP00000027057	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ESZ0 ensembl:ENSRNOP00000027057	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ESZ0 ensembl:ENSRNOP00000027057	P		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ESZ0 ensembl:ENSRNOP00000027057	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ESZ0 ensembl:ENSRNOP00000027057	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ESZ0 ensembl:ENSRNOP00000027057	P		Seeded From UniProt	complete
involved_in	GO:0000012	single strand break repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002706	P		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002706	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002706	C		Seeded From UniProt	complete
involved_in	GO:0006297	nucleotide-excision repair, DNA gap filling	Reactome:R-HSA-5696397	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006288	base-excision repair, DNA ligation	Reactome:R-HSA-73931	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006283	transcription-coupled nucleotide-excision repair	Reactome:R-HSA-6781827	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-73932 Reactome:R-HSA-73931 Reactome:R-HSA-6782227 Reactome:R-HSA-5690997 Reactome:R-HSA-5687675 Reactome:R-HSA-5687673 Reactome:R-HSA-5649734 Reactome:R-HSA-5649726 Reactome:R-HSA-5649724 Reactome:R-HSA-5649723 Reactome:R-HSA-5649705 Reactome:R-HSA-110380 Reactome:R-HSA-110376	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	Reactome:R-HSA-5693538	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Hoch, NC et al. (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature 541 87-91 PubMed GONUTS page
↑ Caldecott, KW et al. (1995) Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Res. 23 4836-43 PubMed GONUTS page
↑ ^3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28002403-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Hoch, NC et al. (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature 541 87-91 PubMed GONUTS page

[PMID:8532526-2] Caldecott, KW et al. (1995) Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Res. 23 4836-43 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:XRCC1

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