HUMAN:XPC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	XPC (synonyms: XPCC)
Protein Name(s)	DNA repair protein complementing XP-C cells Xeroderma pigmentosum group C-complementing protein p125
External Links
UniProt	Q01831
EMBL	D21089 AF261901 AF261892 AF261893 AF261894 AF261895 AF261896 AF261897 AF261898 AF261899 AF261900 KJ535085 AY131066 AK295711 AC093495 FJ695191 FJ695192 BC016620 AK222844 X65024
CCDS	CCDS46763.1
PIR	S44345
RefSeq	NP_004619.3
UniGene	Hs.475538 Hs.739296
PDB	2A4J 2GGM 2OBH
PDBsum	2A4J 2GGM 2OBH
ProteinModelPortal	Q01831
SMR	Q01831
BioGrid	113345
DIP	DIP-31225N
IntAct	Q01831
MINT	MINT-105410
STRING	9606.ENSP00000285021
PhosphoSite	Q01831
DMDM	296453081
MaxQB	Q01831
PaxDb	Q01831
PeptideAtlas	Q01831
PRIDE	Q01831
Ensembl	ENST00000285021 ENST00000476581
GeneID	7508
KEGG	hsa:7508
UCSC	uc011ave.2
CTD	7508
GeneCards	GC03M014161
GeneReviews	XPC
HGNC	HGNC:12816
HPA	CAB009932 HPA035707
MIM	278720 613208
neXtProt	NX_Q01831
Orphanet	276255
PharmGKB	PA37413
eggNOG	COG5535
GeneTree	ENSGT00390000005194
HOGENOM	HOG000124671
HOVERGEN	HBG000407
InParanoid	Q01831
KO	K10838
OMA	PQRTKAG
OrthoDB	EOG7BW0J2
PhylomeDB	Q01831
TreeFam	TF101242
Reactome	REACT_257 REACT_311 REACT_476
ChiTaRS	XPC
EvolutionaryTrace	Q01831
GeneWiki	XPC_(gene)
GenomeRNAi	7508
NextBio	29391
PRO	PR:Q01831
Proteomes	UP000005640
Bgee	Q01831
CleanEx	HS_XPC
ExpressionAtlas	Q01831
Genevestigator	Q01831
GO	GO:0005737 GO:0070062 GO:0005730 GO:0005654 GO:0005634 GO:0005886 GO:0071942 GO:0000405 GO:0003684 GO:0000404 GO:0003697 GO:0006281 GO:0031573 GO:0006289 GO:0000715 GO:0000718 GO:1901990 GO:0042493 GO:0010224
InterPro	IPR004583 IPR018026 IPR018325 IPR018326 IPR018327 IPR018328
PANTHER	PTHR12135
Pfam	PF10403 PF10404 PF10405 PF03835
SMART	SM01030 SM01031 SM01032
TIGRFAMs	TIGR00605

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070914	UV-damage excision repair	PMID:8077226^[1]	ECO:0000314			P		In fig. 6, it is shown XPC is involved in nucleotide excision repair.	complete CACAO 6341
enables	GO:0044877	protein-containing complex binding	PMID:11259578^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(GO:0005675)	Seeded From UniProt	complete
part_of	GO:0000109	nucleotide-excision repair complex	PMID:11259578^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:11259578^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070914	UV-damage excision repair	PMID:8077226^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901990	regulation of mitotic cell cycle phase transition	PMID:17088560^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071942	XPC complex	PMID:11279143^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:8168482^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:9734359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18682493^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18682493^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:12509299^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:12509299^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:10873465^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000715	nucleotide-excision repair, DNA damage recognition	PMID:19941824^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000715	nucleotide-excision repair, DNA damage recognition	PMID:10873465^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071942	XPC complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000253194 UniProtKB:Q01831	C		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000253194 PomBase:SPAC12B10.12c PomBase:SPCC4G3.10c	P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103557 PANTHER:PTN000253194 PomBase:SPAC12B10.12c PomBase:SPCC4G3.10c SGD:S000000964 SGD:S000002722 UniProtKB:Q01831	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000253194 RGD:1305760 UniProtKB:Q01831	C		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000253194 UniProtKB:Q01831	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000253194 SGD:S000000964 UniProtKB:Q01831	F		Seeded From UniProt	complete
part_of	GO:0000111	nucleotide-excision repair factor 2 complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000253194 SGD:S000000964	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A3D8 ensembl:ENSRNOP00000011490	P		Seeded From UniProt	complete
involved_in	GO:0010996	response to auditory stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A3D8 ensembl:ENSRNOP00000011490	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A3D8 ensembl:ENSRNOP00000011490	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A3D8 ensembl:ENSRNOP00000011490	C		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51612 ensembl:ENSMUSP00000032182	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51612 ensembl:ENSMUSP00000032182	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51612 ensembl:ENSMUSP00000032182	P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51612 ensembl:ENSMUSP00000032182	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51612 ensembl:ENSMUSP00000032182	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51612 ensembl:ENSMUSP00000032182	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018326 InterPro:IPR018327 InterPro:IPR018328	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004583	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004583	C		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004583	P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:10873465^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:1522891^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:8168482^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:10873465^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000405	bubble DNA binding	PMID:19941824^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000404	heteroduplex DNA loop binding	PMID:19941824^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070911	global genome nucleotide-excision repair	Reactome:R-HSA-5696399	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006294	nucleotide-excision repair, preincision complex assembly	Reactome:R-HSA-5691000 Reactome:R-HSA-5689861	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6790487 Reactome:R-HSA-6790454 Reactome:R-HSA-6782943 Reactome:R-HSA-5696670 Reactome:R-HSA-5696664 Reactome:R-HSA-5696655 Reactome:R-HSA-5691006 Reactome:R-HSA-5691004 Reactome:R-HSA-5691000 Reactome:R-HSA-5690996 Reactome:R-HSA-5689861 Reactome:R-HSA-4570528	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000717	nucleotide-excision repair, DNA duplex unwinding	Reactome:R-HSA-5690996	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000715	nucleotide-excision repair, DNA damage recognition	Reactome:R-HSA-5696394	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shivji, MK et al. (1994) DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J. Biol. Chem. 269 22749-57 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Araújo, SJ et al. (2001) Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol. Cell. Biol. 21 2281-91 PubMed GONUTS page
↑ Marini, F et al. (2006) DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc. Natl. Acad. Sci. U.S.A. 103 17325-30 PubMed GONUTS page
↑ Araki, M et al. (2001) Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J. Biol. Chem. 276 18665-72 PubMed GONUTS page
↑ ^5.0 ^5.1 Masutani, C et al. (1994) Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 13 1831-43 PubMed GONUTS page
↑ Sugasawa, K et al. (1998) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell 2 223-32 PubMed GONUTS page
↑ ^7.0 ^7.1 Hoogstraten, D et al. (2008) Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC. J. Cell. Sci. 121 2850-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Sugasawa, K et al. (2002) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst.) 1 95-107 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Batty, D et al. (2000) Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J. Mol. Biol. 300 275-90 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Sugasawa, K et al. (2009) Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol. Cell 36 642-53 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Legerski, R & Peterson, C (1992) Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature 359 70-3 PubMed GONUTS page

[PMID:8077226-1] 1.0 ^1.1 Shivji, MK et al. (1994) DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J. Biol. Chem. 269 22749-57 PubMed GONUTS page

[PMID:11259578-2] 2.0 ^2.1 ^2.2 Araújo, SJ et al. (2001) Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol. Cell. Biol. 21 2281-91 PubMed GONUTS page

[PMID:17088560-3] Marini, F et al. (2006) DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc. Natl. Acad. Sci. U.S.A. 103 17325-30 PubMed GONUTS page

[PMID:11279143-4] Araki, M et al. (2001) Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J. Biol. Chem. 276 18665-72 PubMed GONUTS page

[PMID:8168482-5] 5.0 ^5.1 Masutani, C et al. (1994) Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 13 1831-43 PubMed GONUTS page

[PMID:9734359-6] Sugasawa, K et al. (1998) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell 2 223-32 PubMed GONUTS page

[PMID:18682493-7] 7.0 ^7.1 Hoogstraten, D et al. (2008) Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC. J. Cell. Sci. 121 2850-9 PubMed GONUTS page

[PMID:12509299-8] 8.0 ^8.1 Sugasawa, K et al. (2002) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst.) 1 95-107 PubMed GONUTS page

[PMID:10873465-9] 9.0 ^9.1 ^9.2 ^9.3 Batty, D et al. (2000) Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J. Mol. Biol. 300 275-90 PubMed GONUTS page

[PMID:19941824-10] 10.0 ^10.1 ^10.2 Sugasawa, K et al. (2009) Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol. Cell 36 642-53 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1522891-12] Legerski, R & Peterson, C (1992) Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature 359 70-3 PubMed GONUTS page

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HUMAN:XPC

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