HUMAN:WASP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WAS (synonyms: IMD2)
Protein Name(s)	Wiskott-Aldrich syndrome protein WASp
External Links
UniProt	P42768
EMBL	U12707 U18935 U19927 AF115549 AF196970 BC002961 BC012738
CCDS	CCDS14303.1
PIR	A54747
RefSeq	NP_000368.1
UniGene	Hs.2157
PDB	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
PDBsum	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
DisProt	DP00215
ProteinModelPortal	P42768
SMR	P42768
BioGrid	113293
DIP	DIP-431N
IntAct	P42768
MINT	MINT-94655
STRING	9606.ENSP00000365891
PhosphoSite	P42768
MaxQB	P42768
PaxDb	P42768
PRIDE	P42768
DNASU	7454
Ensembl	ENST00000376701
GeneID	7454
KEGG	hsa:7454
UCSC	uc004dkm.4
CTD	7454
GeneCards	GC0XP048534
GeneReviews	WAS
HGNC	HGNC:12731
HPA	CAB004290 HPA002022
MIM	300299 300392 301000 313900
neXtProt	NX_P42768
Orphanet	906 86788 852
PharmGKB	PA37342
eggNOG	NOG270974
GeneTree	ENSGT00730000110895
HOGENOM	HOG000143378
HOVERGEN	HBG000222
InParanoid	P42768
KO	K05747
OMA	TPANEER
PhylomeDB	P42768
TreeFam	TF316736
Reactome	REACT_12623 REACT_160086
ChiTaRS	WAS
EvolutionaryTrace	P42768
GeneWiki	Wiskott%E2%80%93Aldrich_syndrome_protein
GenomeRNAi	7454
NextBio	29188
PRO	PR:P42768
Proteomes	UP000005640
Bgee	P42768
CleanEx	HS_WAS
ExpressionAtlas	P42768
Genevestigator	P42768
GO	GO:0015629 GO:0005911 GO:0005829 GO:0070062 GO:0012506 GO:0042802 GO:0043274 GO:0019901 GO:0017124 GO:0005083 GO:0030041 GO:0030048 GO:0008154 GO:0007596 GO:0006952 GO:0016197 GO:0008544 GO:0038096 GO:0006955 GO:0045087 GO:2000601 GO:0006461 GO:0050790 GO:0042110 GO:0050852
Gene3D	2.30.29.30 3.90.810.10
InterPro	IPR000095 IPR011993 IPR027641 IPR011026 IPR000697 IPR003124
PANTHER	PTHR12779:SF2
Pfam	PF00786 PF00568 PF02205
SMART	SM00285 SM00461 SM00246
SUPFAM	SSF47912
PROSITE	PS50108 PS50229 PS51082

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002625	regulation of T cell antigen processing and presentation	PMID:22804504^[1]	ECO:0000315			P		Fig 7b shows that the stained WASP-deficient T-cells show a reduction in the presence of antigens just on the mid body. Instead they are spread all the way down to the uropod.	complete CACAO 5733
	GO:2000146	negative regulation of cell motility	PMID:22804504^[1]	ECO:0000315			P		Fig 2a shows that in the presence of JY cells, the motility of WASP deficient T-cells is significantly increased.	complete CACAO 5734
NOT\|involved_in	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	PMID:29925947^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:29925947^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030041	actin filament polymerization	PMID:29925947^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905168	positive regulation of double-strand break repair via homologous recombination	PMID:29925947^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29925947^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20574068^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20574068^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	PMID:10724160^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60953	F		Seeded From UniProt	complete
involved_in	GO:0008064	regulation of actin polymerization or depolymerization	PMID:8625410^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0007266	Rho protein signal transduction	PMID:8625410^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:8625410^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
involved_in	GO:0032488	Cdc42 protein signal transduction	PMID:8625410^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:19798448^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9XUS7	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:19798448^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5T0N5	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:19798448^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q19253	F		Seeded From UniProt	complete
involved_in	GO:0051492	regulation of stress fiber assembly	PMID:8625410^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
involved_in	GO:0010591	regulation of lamellipodium assembly	PMID:8625410^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
involved_in	GO:0051492	regulation of stress fiber assembly	PMID:8625410^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0010591	regulation of lamellipodium assembly	PMID:8625410^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:8625410^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051497	negative regulation of stress fiber assembly	PMID:8625410^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	PMID:8625410^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60953	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8625410^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:2000146	negative regulation of cell motility	PMID:22804504^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002625	regulation of T cell antigen processing and presentation	PMID:22804504^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06187	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06187	F		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19174	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19174	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42680	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08881	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08881	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:8892607^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42680	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:8069912^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051666	actin cortical patch localization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001506182 SGD:S000004329 SGD:S000005707	P		Seeded From UniProt	complete
involved_in	GO:0051127	positive regulation of actin nucleation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001506182 PomBase:SPBC13E7.09	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0243516 PANTHER:PTN001506182	F		Seeded From UniProt	complete
part_of	GO:0030479	actin cortical patch	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001506182 PomBase:SPAC4F10.15c PomBase:SPBC13E7.09 SGD:S000004329 SGD:S000005707 UniProtKB:A0A1D8PU03	C		Seeded From UniProt	complete
involved_in	GO:0030048	actin filament-based movement	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105059 MGI:MGI:2178801 PANTHER:PTN001506182	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001506182 PomBase:SPAC4F10.15c SGD:S000004329 UniProtKB:A0A1D8PU03	P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2178801 PANTHER:PTN001506182 RGD:620887 UniProtKB:P42768	C		Seeded From UniProt	complete
involved_in	GO:0000147	actin cortical patch assembly	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001506182 PomBase:SPAC4F10.15c PomBase:SPBC13E7.09	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18650809^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42768	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12769847^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42768	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10724160^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42768	F		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030695	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	F		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	P		Seeded From UniProt	complete
involved_in	GO:0030048	actin filament-based movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	P		Seeded From UniProt	complete
involved_in	GO:0030041	actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	P		Seeded From UniProt	complete
involved_in	GO:0016197	endosomal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	P		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	C		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70315 ensembl:ENSMUSP00000033505	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003124 InterPro:IPR027641	F		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011026 InterPro:IPR027641	P		Seeded From UniProt	complete
involved_in	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027641	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:8625410^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	PMID:8069912^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	PMID:8625410^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:8069912^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:8069912^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:8625410^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030695	GTPase regulator activity	PMID:8625410^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-430180 Reactome:R-HSA-2197698 Reactome:R-HSA-2197691 Reactome:R-HSA-2197690 Reactome:R-HSA-2029466	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Lafouresse, F et al. (2012) Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. Immunology 137 183-96 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Schrank, BR et al. (2018) Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559 61-66 PubMed GONUTS page
↑ ^3.0 ^3.1 Taylor, MD et al. (2010) Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome. Sci Transl Med 2 37ra44 PubMed GONUTS page
↑ ^4.0 ^4.1 Kim, AS et al. (2000) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404 151-8 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 Symons, M et al. (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84 723-34 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Giuliani, C et al. (2009) Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet. 5 e1000675 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Cory, GO et al. (1996) Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J. Immunol. 157 3791-5 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Derry, JM et al. (1994) Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 78 635-44 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cheng, HC et al. (2008) Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature 454 1009-13 PubMed GONUTS page
↑ Cory, GO et al. (2003) Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol. Cell 11 1229-39 PubMed GONUTS page

[PMID:22804504-1] 1.0 ^1.1 ^1.2 ^1.3 Lafouresse, F et al. (2012) Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. Immunology 137 183-96 PubMed GONUTS page

[PMID:29925947-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Schrank, BR et al. (2018) Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559 61-66 PubMed GONUTS page

[PMID:20574068-3] 3.0 ^3.1 Taylor, MD et al. (2010) Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome. Sci Transl Med 2 37ra44 PubMed GONUTS page

[PMID:10724160-4] 4.0 ^4.1 Kim, AS et al. (2000) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404 151-8 PubMed GONUTS page

[PMID:8625410-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 Symons, M et al. (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84 723-34 PubMed GONUTS page

[PMID:19798448-6] 6.0 ^6.1 ^6.2 Giuliani, C et al. (2009) Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet. 5 e1000675 PubMed GONUTS page

[PMID:8892607-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Cory, GO et al. (1996) Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J. Immunol. 157 3791-5 PubMed GONUTS page

[PMID:20458337-8] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:8069912-9] 9.0 ^9.1 ^9.2 ^9.3 Derry, JM et al. (1994) Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 78 635-44 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18650809-11] Cheng, HC et al. (2008) Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature 454 1009-13 PubMed GONUTS page

[PMID:12769847-12] Cory, GO et al. (2003) Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol. Cell 11 1229-39 PubMed GONUTS page

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HUMAN:WASP

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