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HUMAN:VNN1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) VNN1
Protein Name(s) Pantetheinase

Pantetheine hydrolase Tiff66 Vascular non-inflammatory molecule 1 Vanin-1

External Links
UniProt O95497
EMBL AJ132099
U39664
AK290425
DQ100297
AL032821
BC096265
BC096266
BC096267
BC096268
CCDS CCDS5159.1
RefSeq NP_004657.2
UniGene Hs.12114
Hs.720659
ProteinModelPortal O95497
SMR O95497
STRING 9606.ENSP00000356905
PhosphoSite O95497
PaxDb O95497
PeptideAtlas O95497
PRIDE O95497
Ensembl ENST00000367928
GeneID 8876
KEGG hsa:8876
UCSC uc003qdo.3
CTD 8876
GeneCards GC06M133001
H-InvDB HIX0022602
HGNC HGNC:12705
MIM 603570
neXtProt NX_O95497
PharmGKB PA37321
eggNOG COG0388
GeneTree ENSGT00390000013823
HOVERGEN HBG003996
InParanoid O95497
KO K08069
OMA RYYLQIC
OrthoDB EOG7HF1J0
PhylomeDB O95497
TreeFam TF323645
GeneWiki VNN1
GenomeRNAi 8876
NextBio 33325
PRO PR:O95497
Proteomes UP000005640
Bgee O95497
CleanEx HS_VNN1
Genevestigator O95497
GO GO:0031225
GO:0070062
GO:0016021
GO:0005886
GO:0034235
GO:0017159
GO:0002526
GO:0006928
GO:0002544
GO:0006954
GO:0045087
GO:1902176
GO:0015939
GO:0033089
GO:0006979
GO:0016337
Gene3D 3.60.110.10
InterPro IPR012101
IPR003010
PANTHER PTHR10609
Pfam PF00795
PIRSF PIRSF011861
SUPFAM SSF56317
PROSITE PS50263

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0017159

pantetheine hydrolase activity

PMID:24140347[1]

ECO:0000315

F

In the article, Figure 2 shows that wild-type cells have much higher pantetheinase activity compared to mutant cells with Vnn1 knocked out, indicating that Vnn1 has pantetheine hydrolase activity.

complete
CACAO 10119

involved_in

GO:0015939

pantothenate metabolic process

PMID:25478849[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017159

pantetheine hydrolase activity

PMID:25478849[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1902176

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

PMID:15282320[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:14966568[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

involved_in

GO:0033089

positive regulation of T cell differentiation in thymus

PMID:11491533[5]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

enables

GO:0017159

pantetheine hydrolase activity

PMID:11491533[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0098609

cell-cell adhesion

PMID:11491533[5]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

involved_in

GO:0015939

pantothenate metabolic process

PMID:11491533[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:15282320[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

involved_in

GO:0002544

chronic inflammatory response

PMID:14966568[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

involved_in

GO:0002526

acute inflammatory response

PMID:14966568[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0K8

P

Seeded From UniProt

complete

enables

GO:0017159

pantetheine hydrolase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347055
PANTHER:PTN000064612
UniProtKB:O95497
UniProtKB:O95498

F

Seeded From UniProt

complete

involved_in

GO:0015939

pantothenate metabolic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347055
PANTHER:PTN000064612
UniProtKB:O95497
UniProtKB:O95498

P

Seeded From UniProt

complete

involved_in

GO:1902176

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0098609

cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0033089

positive regulation of T cell differentiation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0002544

chronic inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0002526

acute inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0K8
ensembl:ENSMUSP00000040599

P

Seeded From UniProt

complete

involved_in

GO:0006807

nitrogen compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003010

P

Seeded From UniProt

complete

enables

GO:0016811

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012101

F

Seeded From UniProt

complete

enables

GO:0017159

pantetheine hydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.92

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:17145956[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:17145956[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035577

azurophil granule membrane

Reactome:R-HSA-6798739

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015939

pantothenate metabolic process

Reactome:R-HSA-199220

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8940388
Reactome:R-HSA-8938300
Reactome:R-HSA-6798739

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-8940388

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0031225

anchored component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0336

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Rommelaere, S et al. (2013) PPARalpha regulates the production of serum Vanin-1 by liver. FEBS Lett. 587 3742-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 Boersma, YL et al. (2014) The structure of vanin 1: a key enzyme linking metabolic disease and inflammation. Acta Crystallogr. D Biol. Crystallogr. 70 3320-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 Berruyer, C et al. (2004) Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress. Mol. Cell. Biol. 24 7214-24 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Martin, F et al. (2004) Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores. J. Clin. Invest. 113 591-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Martin, F et al. () Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics 53 296-306 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Berruyer, C et al. (2006) Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. J. Exp. Med. 203 2817-27 PubMed GONUTS page
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