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PMID:24140347
| Citation |
Rommelaere, S, Millet, V, Gensollen, T, Bourges, C, Eeckhoute, J, Hennuyer, N, Baugé, E, Chasson, L, Cacciatore, I, Staels, B, Pitari, G, Galland, F and Naquet, P (2013) PPARalpha regulates the production of serum Vanin-1 by liver. FEBS Lett. 587:3742-8 |
|---|---|
| Abstract |
The membrane-bound Vanin-1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin-1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified in the Vnn1 promoter. These results indicate that serum Vnn1 might be a reliable reporter of PPARalpha activity in liver. |
| Links |
PubMed Online version:10.1016/j.febslet.2013.09.046 |
| Keywords |
Amidohydrolases/blood; Amidohydrolases/genetics; Animals; Caco-2 Cells; Female; GPI-Linked Proteins/blood; GPI-Linked Proteins/genetics; Gene Expression; Gene Expression Regulation; Hepatocytes/enzymology; Hepatocytes/secretion; Humans; Liver/cytology; Liver/enzymology; Male; Mice; Mice, Inbred C57BL; PPAR alpha/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0017159: pantetheine hydrolase activity |
ECO:0000315: |
F |
In the article, Figure 2 shows that wild-type cells have much higher pantetheinase activity compared to mutant cells with Vnn1 knocked out, indicating that Vnn1 has pantetheine hydrolase activity. |
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Notes
See also
References
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