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PMID:11491533
| Citation |
Martin, F, Malergue, F, Pitari, G, Philippe, JM, Philips, S, Chabret, C, Granjeaud, S, Mattei, MG, Mungall, AJ, Naquet, P and Galland, F Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics 53:296-306 |
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| Abstract |
The mouse Vanin-1 molecule plays a role in thymic reconstitution following damage by irradiation. We recently demonstrated that it is a membrane pantetheinase (EC 3.56.1.-). This molecule is the prototypic member of a larger Vanin family encoded by at least two mouse (Vanin-1 and Vanin-3) and three human (VNN1, VNN2, VNN3) orthologous genes. We now report (1) the structural characterization of the human and mouse Vanin genes and their organization in clusters on the 6q22-24 and 10A2B1 chromosomes, respectively; (2) identification of the human VNN3 gene and the demonstration that the mouse Vanin-3 molecule is secreted by cells, and (3) that the Vanin genes encode different isoforms of the mammalian pantetheinase activity. Thus, the Vanin family represents a novel class of secreted or membrane-associated ectoenzymes. We discuss here their possible role in processes pertaining to tissue repair in the context of oxidative stress. |
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| Keywords |
Amidohydrolases/genetics; Amino Acid Sequence; Animals; Base Sequence; Cell Adhesion Molecules/genetics; Chromosomes, Human, Pair 6/genetics; Conserved Sequence; GPI-Linked Proteins; Humans; Membrane Proteins/genetics; Mice; Molecular Sequence Data; Multigene Family; Protein Isoforms/genetics; Sequence Homology, Amino Acid; Tissue Distribution |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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