HUMAN:VEGFC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	VEGFC
Protein Name(s)	Vascular endothelial growth factor C VEGF-C Flt4 ligand Flt4-L Vascular endothelial growth factor-related protein VRP
External Links
UniProt	P49767
EMBL	X94216 U43142 U58111 AK313879 AC092673 AC093801 CH471056 BC035212 BC063685
CCDS	CCDS43285.1
PIR	S69207
RefSeq	NP_005420.1
UniGene	Hs.435215
PDB	2X1W 2X1X 4BSK
PDBsum	2X1W 2X1X 4BSK
ProteinModelPortal	P49767
SMR	P49767
BioGrid	113267
DIP	DIP-5738N
IntAct	P49767
STRING	9606.ENSP00000280193
TCDB	9.B.88.2.1
PhosphoSite	P49767
DMDM	1718154
PaxDb	P49767
PRIDE	P49767
DNASU	7424
Ensembl	ENST00000618562
GeneID	7424
KEGG	hsa:7424
UCSC	uc003ius.1
CTD	7424
GeneCards	GC04M177604
HGNC	HGNC:12682
MIM	601528 615907
neXtProt	NX_P49767
Orphanet	79452
PharmGKB	PA37304
eggNOG	NOG79308
GeneTree	ENSGT00730000110889
HOGENOM	HOG000231512
HOVERGEN	HBG073119
InParanoid	P49767
KO	K05449
OrthoDB	EOG7J17ZS
PhylomeDB	P49767
TreeFam	TF319554
Reactome	REACT_12380 REACT_12583
ChiTaRS	VEGFC
EvolutionaryTrace	P49767
GeneWiki	Vascular_endothelial_growth_factor_C
GenomeRNAi	7424
NextBio	29082
PMAP-CutDB	P49767
PRO	PR:P49767
Proteomes	UP000005640
Bgee	P49767
CleanEx	HS_VEGFC
Genevestigator	P49767
GO	GO:0005576 GO:0005615 GO:0016020 GO:0031093 GO:0042056 GO:0001525 GO:0007596 GO:0050930 GO:0016331 GO:0045776 GO:0008285 GO:0009887 GO:0030168 GO:0002576 GO:0050918 GO:0045766 GO:0043536 GO:0051781 GO:0008284 GO:0001954 GO:0050679 GO:1901492 GO:0060754 GO:0002052 GO:0050731 GO:0031954 GO:0050714 GO:0030947 GO:0042493 GO:0007165 GO:0006929 GO:0048010
Gene3D	2.10.90.10
InterPro	IPR004153 IPR029034 IPR023581 IPR000072
Pfam	PF03128 PF00341
SMART	SM00141
SUPFAM	SSF57501
PROSITE	PS00249 PS50278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010467	gene expression	PMID:24551192^[1]	ECO:0000314			P	Figure 1. Characterization of Vpu-expressing cell lines.	complete CACAO 9545
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:23878260^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043185	vascular endothelial growth factor receptor 3 binding	PMID:23878260^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35916	F	Seeded From UniProt	complete
involved_in	GO:0060754	positive regulation of mast cell chemotaxis	PMID:19275959^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050930	induction of positive chemotaxis	PMID:19275959^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:19275959^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0060754	positive regulation of mast cell chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	P	Seeded From UniProt	complete
involved_in	GO:0050930	induction of positive chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619991 RGD:620695 UniProtKB:P15692 UniProtKB:P49767 ZFIN:ZDB-GENE-990415-273	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619850 RGD:619991 UniProtKB:P15692	P	Seeded From UniProt	complete
enables	GO:0043185	vascular endothelial growth factor receptor 3 binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109124 PANTHER:PTN002635033 RGD:619800 UniProtKB:P49767	F	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619991 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	F	Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 UniProtKB:P15692 ZFIN:ZDB-GENE-040303-4	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 PANTHER:PTN000246442 RGD:619991 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49763	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:105095 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619850 RGD:619991 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49765	C	Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619800 RGD:619991 RGD:620695 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767 ZFIN:ZDB-GENE-040303-4	F	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619850 ZFIN:ZDB-GENE-030131-4605 ZFIN:ZDB-GENE-040303-4	P	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619850 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49765	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:P15692	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 RGD:619850 RGD:619991 RGD:620695 UniProtKB:P15692	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619799 RGD:619800 RGD:619991 UniProtKB:P15692 ZFIN:ZDB-GENE-070810-6	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
enables	GO:0043185	vascular endothelial growth factor receptor 3 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35757 ensembl:ENSRNOP00000015529	P	Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
involved_in	GO:1901492	positive regulation of lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
enables	GO:0043185	vascular endothelial growth factor receptor 3 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	F	Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97953 ensembl:ENSMUSP00000033919	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072	C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8617204^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8617204^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006929	substrate-dependent cell migration	PMID:8617204^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194313	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-481007 Reactome:R-HSA-195378 Reactome:R-HSA-194310 Reactome:R-HSA-194308	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Patel, P et al. (2014) The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells. PLoS ONE 9 e88934 PubMed GONUTS page
↑ ^2.0 ^2.1 Leppänen, VM et al. (2013) Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proc. Natl. Acad. Sci. U.S.A. 110 12960-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Detoraki, A et al. (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J. Allergy Clin. Immunol. 123 1142-9, 1149.e1-5 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Joukov, V et al. (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15 290-98 PubMed GONUTS page

[PMID:24551192-1] Patel, P et al. (2014) The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells. PLoS ONE 9 e88934 PubMed GONUTS page

[PMID:23878260-2] 2.0 ^2.1 Leppänen, VM et al. (2013) Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proc. Natl. Acad. Sci. U.S.A. 110 12960-5 PubMed GONUTS page

[PMID:19275959-3] 3.0 ^3.1 ^3.2 Detoraki, A et al. (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J. Allergy Clin. Immunol. 123 1142-9, 1149.e1-5 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8617204-5] 5.0 ^5.1 ^5.2 Joukov, V et al. (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15 290-98 PubMed GONUTS page

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HUMAN:VEGFC

Contents

Annotations

Notes

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