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HUMAN:UPAR
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PLAUR (synonyms: MO3, UPAR) | |
| Protein Name(s) | Urokinase plasminogen activator surface receptor
U-PAR uPAR Monocyte activation antigen Mo3 | |
| External Links | ||
| UniProt | Q03405 | |
| EMBL | X51675 M83246 X74039 U09346 U09347 U08839 U09937 U09931 U09932 U09933 U09935 U09936 AY194849 AK290774 CR456952 AC005525 AC006953 AC006953 CH471126 BC002788 AF257789 AY029180 S78532 | |
| CCDS | CCDS12628.1 CCDS33041.1 CCDS33042.1 | |
| PIR | I52614 S12376 S39495 | |
| RefSeq | NP_001005376.1 NP_001005377.1 NP_001287966.1 NP_002650.1 | |
| UniGene | Hs.466871 | |
| PDB | 1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 | |
| PDBsum | 1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 | |
| ProteinModelPortal | Q03405 | |
| SMR | Q03405 | |
| BioGrid | 111345 | |
| DIP | DIP-137N | |
| IntAct | Q03405 | |
| MINT | MINT-1370900 | |
| BindingDB | Q03405 | |
| ChEMBL | CHEMBL4883 | |
| DrugBank | DB00009 DB00029 DB00015 DB00031 DB00013 | |
| DMDM | 465003 | |
| MaxQB | Q03405 | |
| PaxDb | Q03405 | |
| PRIDE | Q03405 | |
| DNASU | 5329 | |
| Ensembl | ENST00000221264 ENST00000339082 ENST00000340093 | |
| GeneID | 5329 | |
| KEGG | hsa:5329 | |
| UCSC | uc002oxd.2 uc002oxf.2 uc002oxg.2 | |
| CTD | 5329 | |
| GeneCards | GC19M044150 | |
| HGNC | HGNC:9053 | |
| HPA | HPA050843 | |
| MIM | 173391 | |
| neXtProt | NX_Q03405 | |
| PharmGKB | PA33383 | |
| eggNOG | NOG41870 | |
| GeneTree | ENSGT00510000049144 | |
| HOVERGEN | HBG000245 | |
| InParanoid | Q03405 | |
| KO | K03985 | |
| OMA | TNRTMSY | |
| OrthoDB | EOG7QRQVG | |
| PhylomeDB | Q03405 | |
| TreeFam | TF338662 | |
| Reactome | REACT_1830 REACT_641 | |
| EvolutionaryTrace | Q03405 | |
| GeneWiki | Urokinase_receptor | |
| GenomeRNAi | 5329 | |
| NextBio | 20632 | |
| PMAP-CutDB | Q03405 | |
| PRO | PR:Q03405 | |
| Proteomes | UP000005640 | |
| Bgee | Q03405 | |
| ExpressionAtlas | Q03405 | |
| Genevestigator | Q03405 | |
| GO | GO:0031225 GO:0005788 GO:0005789 GO:0070062 GO:0019898 GO:0005925 GO:0016021 GO:0005887 GO:0071438 GO:0005886 GO:0019899 GO:0004872 GO:0030377 GO:0016255 GO:0007596 GO:0006501 GO:0006928 GO:0044267 GO:0006935 GO:0042730 GO:0043687 GO:0030162 GO:0007165 GO:0038195 | |
| InterPro | IPR018363 IPR016054 IPR001526 | |
| Pfam | PF00021 | |
| SMART | SM00134 | |
| PROSITE | PS00983 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 4A shows that silencing uPAR and MMP-9 inhibits phosphorylation in the EGFR pathway. |
complete | ||||
| GO:0006916 |
anti-apoptosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Figure 1C and 1D show, through the Apo BrdU Assay and the Annexin-V assay, that inhibition of uPAR and MMP-9 induce apoptosis in Daoy and D283 cells. |
complete | ||||
| GO:0043388 |
positive regulation of DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Figure 4C shows (through EMSA) that downregulation of uPAR and MMP-9 significantly inhibits binding activity of nuclear extract to STAT3 DNA probe. |
complete | ||||
| GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 4B shows, through pUM transfection, that silencing uPAR and MMP-9 significantly lowers the amount of phosphorylated STAT protein in the nucleus. |
complete | ||||
| GO:0008633 |
obsolete activation of pro-apoptotic gene products |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 2 |
complete | ||||
| GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 4B shows, through pUM transfection, that silencing uPAR and MMP-9 significantly lowers the amount of phosphorylated STAT protein in the nucleus. |
complete | ||||
| GO:0008637 |
apoptotic mitochondrial changes |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 2B shows, through the transfection of Daoy and D283 cells, that downregulation of uPAR and MMP-9 reduces mitochondrial cytochrome C and Bak levels. |
complete | ||||
| GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 1C and 1D show, through the Apo BrdU Assay and the Annexin-V assay, that inhibition of uPAR and MMP-9 induce apoptosis in Daoy and D283 cells. |
complete | ||||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 2 shows that downregulation of uPAR and MMP9 increases levels of gene products that induce apoptosis, showing that normal function negatively regulates apoptotic signaling pathways. |
complete | ||||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 2 shows that downregulation of uPAR and MMP9 in medulloblastoma cells decreases the amount of cytosolic cytochrome c, indicating a reduction in release of cytochrome c from mitochondria. |
complete | ||||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 3 showed that down regulation of uPAR and MMP9 in Daoy and D283 cells activates caspase activity. Synonym for negative regulation of caspase activity is negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. |
complete | ||||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
| GO:2001268 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 3 showed that down regulation of uPAR and MMP9 in Daoy and D283 cells activates caspase activity. |
complete | ||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030377 |
urokinase plasminogen activator receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030377 |
urokinase plasminogen activator receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030162 |
regulation of proteolysis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000835544 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35456 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030162 |
regulation of proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030377 |
urokinase plasminogen activator receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038195 |
urokinase plasminogen activator signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019898 |
extrinsic component of membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
PMID:10749881[10] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042730 |
fibrinolysis |
Reactome:R-HSA-75205 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035579 |
specific granule membrane |
Reactome:R-HSA-6799350 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-162836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-162836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031225 |
anchored component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0071438 |
invadopodium membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Kotipatruni, RR et al. (2012) Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma. PLoS ONE 7 e44798 PubMed GONUTS page
- ↑ 2.0 2.1 Jin, H et al. (2005) Group A streptococcal surface GAPDH, SDH, recognizes uPAR/CD87 as its receptor on the human pharyngeal cell and mediates bacterial adherence to host cells. J. Mol. Biol. 350 27-41 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kreiling, JL et al. (2003) Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR. J. Biol. Chem. 278 20628-37 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Roldan, AL et al. (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J. 9 467-74 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Pyke, C et al. (1993) An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. FEBS Lett. 326 69-74 PubMed GONUTS page
- ↑ Beaufort, N et al. (2004) Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J. Immunol. 172 540-9 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 9.0 9.1 Casey, JR et al. (1994) The structure of the urokinase-type plasminogen activator receptor gene. Blood 84 1151-6 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Mukhina, S et al. (2000) The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis. J. Biol. Chem. 275 16450-8 PubMed GONUTS page
c
e
n
o
- GO:0008633 ! obsolete activation of pro-apoptotic gene products
- GO:0031225 ! obsolete anchored component of membrane
- GO:0071438 ! obsolete invadopodium membrane
- GO:0043154 ! obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:2001268 ! obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
p
- GO:0005886 ! plasma membrane
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0043388 ! positive regulation of DNA binding
- GO:0090200 ! positive regulation of release of cytochrome c from mitochondria
- GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
- Primates
- GO:0019904 ! protein domain specific binding
s
u
