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PMID:8392005

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Citation

Pyke, C, Eriksen, J, Solberg, H, Nielsen, BS, Kristensen, P, Lund, LR and Danø, K (1993) An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. FEBS Lett. 326:69-74

Abstract

Using 3' RACE (rapid amplification of cDNA ends), we have isolated a cDNA variant for the receptor for human urokinase plasminogen activator (uPAR). The deduced protein includes the amino-terminal ligand binding domain in uPAR, but lacks the carboxy-terminal membrane attachment by a glycolipid anchor. Genomic DNA analysis showed that the uPAR mRNA variant is generated by alternative splicing. The new variant mRNA is expressed in various human cell lines and tissues and both variants are up-regulated by phorbol ester in A549 cells. We propose that the alternatively spliced uPAR mRNA encodes a soluble uPA binding protein, the possible function of which is discussed.

Links

PubMed

Keywords

Amino Acid Sequence; Base Sequence; DNA/genetics; Gene Amplification; Genetic Variation; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Protein Biosynthesis; RNA Splicing; RNA, Messenger/genetics; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/genetics; Receptors, Urokinase Plasminogen Activator; Ribonucleases

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:UPAR

enables

GO:0038023: signaling receptor activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:UPAR

involved_in

GO:0007596: blood coagulation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:UPAR

enables

GO:0030377: urokinase plasminogen activator receptor activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete


See also

References

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