HUMAN:ULA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NAE1 (synonyms: APPBP1)
Protein Name(s)	NEDD8-activating enzyme E1 regulatory subunit Amyloid beta precursor protein-binding protein 1, 59 kDa APP-BP1 Amyloid protein-binding protein 1 Proto-oncogene protein 1
External Links
UniProt	Q13564
EMBL	U50939 AY197612 AK097680 AK298159 AK312784 AC004638 AC044802 AL136798 CH471092 BC000480 BC013301
CCDS	CCDS10820.1 CCDS42171.1 CCDS42172.1 CCDS67050.1
RefSeq	NP_001018169.1 NP_001018170.1 NP_001273429.1 NP_003896.1 XP_005256272.1
UniGene	Hs.460978
PDB	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
PDBsum	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
ProteinModelPortal	Q13564
SMR	Q13564
BioGrid	114402
IntAct	Q13564
MINT	MINT-1429663
STRING	9606.ENSP00000290810
BindingDB	Q13564
ChEMBL	CHEMBL2016431
DrugBank	DB00171
PhosphoSite	Q13564
DMDM	50400302
MaxQB	Q13564
PaxDb	Q13564
PRIDE	Q13564
DNASU	8883
Ensembl	ENST00000290810 ENST00000359087 ENST00000379463 ENST00000394074
GeneID	8883
KEGG	hsa:8883
UCSC	uc002eqe.3 uc002eqf.3
CTD	8883
GeneCards	GC16M066836
HGNC	HGNC:621
HPA	HPA041178 HPA042041
MIM	603385
neXtProt	NX_Q13564
PharmGKB	PA162396730
eggNOG	COG0476
GeneTree	ENSGT00550000074901
HOGENOM	HOG000216537
HOVERGEN	HBG079761
InParanoid	Q13564
KO	K04532
OMA	KSYKEKE
PhylomeDB	Q13564
TreeFam	TF313972
UniPathway	UPA00885
ChiTaRS	NAE1
EvolutionaryTrace	Q13564
GeneWiki	APPBP1
GenomeRNAi	8883
NextBio	33357
PRO	PR:Q13564
Proteomes	UP000005640
Bgee	Q13564
CleanEx	HS_NAE1
ExpressionAtlas	Q13564
Genevestigator	Q13564
GO	GO:0005737 GO:0005829 GO:0005634 GO:0005886 GO:0003824 GO:0046982 GO:0031625 GO:0033314 GO:0051402 GO:0045116 GO:0042981 GO:0043523 GO:0007165
Gene3D	3.40.50.720
InterPro	IPR009036 IPR016040 IPR000594
Pfam	PF00899
SUPFAM	SSF69572

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042981	regulation of apoptotic process	PMID:10722740^[1]	ECO:0000315			P	Figure 5	complete CACAO 4338
part_of	GO:0032991	protein-containing complex	PMID:12740388^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:10722740^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	PMID:14557245^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:12740388^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8TBC4	F	Seeded From UniProt	complete
involved_in	GO:0045116	protein neddylation	PMID:10207026^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045116	protein neddylation	PMID:12740388^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:10722740^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:14557245^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033314	mitotic DNA replication checkpoint	PMID:10722740^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18627766^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14669	F	Seeded From UniProt	complete
contributes_to	GO:0019781	NEDD8 activating enzyme activity	PMID:12740388^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045116	protein neddylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261112 PANTHER:PTN000102175 SGD:S000005924 UniProtKB:Q13564	P	Seeded From UniProt	complete
involved_in	GO:0032446	protein modification by small protein conjugation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023143 FB:FBgn0029113 FB:FBgn0029512 FB:FBgn0032054 FB:FBgn0034366 FB:FBgn0261112 FB:FBgn0263697 MGI:MGI:1913894 MGI:MGI:1913913 MGI:MGI:1921494 MGI:MGI:98890 MGI:MGI:98891 PANTHER:PTN000102039 PomBase:SPAC4C5.04 PomBase:SPBC1604.21c PomBase:SPBC16H5.03c SGD:S000001153 SGD:S000001214 SGD:S000001693 SGD:S000002798 SGD:S000005924 SGD:S000006270 SGD:S000006384 TAIR:locus:2060854 TAIR:locus:2159727 TAIR:locus:2164270 TAIR:locus:2832477 UniProtKB:A0AVT1 UniProtKB:P22314 UniProtKB:P41226 UniProtKB:P42744 UniProtKB:Q13564 UniProtKB:Q5BAI0 UniProtKB:Q8I553 UniProtKB:Q8I5F9 UniProtKB:Q8IDZ6 UniProtKB:Q9GZZ9 UniProtKB:Q9SJT1 UniProtKB:Q9UBE0 UniProtKB:Q9UBT2 UniProtKB:Q9ZV69 WB:WBGene00000142 WB:WBGene00004341 WB:WBGene00006699 WB:WBGene00006700 ZFIN:ZDB-GENE-040625-21	P	Seeded From UniProt	complete
enables	GO:0019781	NEDD8 activating enzyme activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000102175 SGD:S000005924	F	Seeded From UniProt	complete
enables	GO:0019781	NEDD8 activating enzyme activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261112 PANTHER:PTN000102175 SGD:S000005924 UniProtKB:Q13564	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10154 EcoGene:EG11587 FB:FBgn0029113 FB:FBgn0032054 MGI:MGI:1921494 PANTHER:PTN000102040 PomBase:SPBC1604.21c SGD:S000001214 SGD:S000001693 SGD:S000006384 TAIR:locus:2060854 TAIR:locus:2152375 TAIR:locus:2164270 TAIR:locus:2207185 UniProtKB:A0AVT1 UniProtKB:O95352 UniProtKB:O95396 UniProtKB:P42744 UniProtKB:Q8I5F9 UniProtKB:Q8ID54 UniProtKB:Q8IDZ6 UniProtKB:Q9GZZ9 UniProtKB:Q9SJT1 UniProtKB:Q9ZV69 WB:WBGene00004341 dictyBase:DDB_G0271096	C	Seeded From UniProt	complete
enables	GO:0008641	ubiquitin-like modifier activating enzyme activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000594 InterPro:IPR035985	F	Seeded From UniProt	complete
enables	GO:0019781	NEDD8 activating enzyme activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030667	F	Seeded From UniProt	complete
involved_in	GO:0045116	protein neddylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030667	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8626687^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8626687^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8951766 Reactome:R-HSA-8951764 Reactome:R-HSA-8951751 Reactome:R-HSA-8951661 Reactome:R-HSA-8951656 Reactome:R-HSA-8951648	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0045116	protein neddylation	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00885	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chen, Y et al. (2000) The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J. Biol. Chem. 275 8929-35 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Bohnsack, RN & Haas, AL (2003) Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J. Biol. Chem. 278 26823-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Chen, Y et al. (2003) APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J. Cell Biol. 163 27-33 PubMed GONUTS page
↑ Gong, L & Yeh, ET (1999) Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J. Biol. Chem. 274 12036-42 PubMed GONUTS page
↑ Park, Y et al. (2008) TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Biochem. Biophys. Res. Commun. 374 294-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Chow, N et al. (1996) APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. J. Biol. Chem. 271 11339-46 PubMed GONUTS page

[PMID:10722740-1] 1.0 ^1.1 ^1.2 ^1.3 Chen, Y et al. (2000) The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J. Biol. Chem. 275 8929-35 PubMed GONUTS page

[PMID:12740388-2] 2.0 ^2.1 ^2.2 ^2.3 Bohnsack, RN & Haas, AL (2003) Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J. Biol. Chem. 278 26823-30 PubMed GONUTS page

[PMID:14557245-3] 3.0 ^3.1 Chen, Y et al. (2003) APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J. Cell Biol. 163 27-33 PubMed GONUTS page

[PMID:10207026-4] Gong, L & Yeh, ET (1999) Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J. Biol. Chem. 274 12036-42 PubMed GONUTS page

[PMID:18627766-5] Park, Y et al. (2008) TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Biochem. Biophys. Res. Commun. 374 294-8 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8626687-7] 7.0 ^7.1 Chow, N et al. (1996) APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. J. Biol. Chem. 271 11339-46 PubMed GONUTS page

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HUMAN:ULA1

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