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HUMAN:UBXN6
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | UBXN6 (synonyms: UBXD1, UBXDC2) | |
| Protein Name(s) | UBX domain-containing protein 6
UBX domain-containing protein 1 | |
| External Links | ||
| UniProt | Q9BZV1 | |
| EMBL | AF272893 AF272894 CH471139 CH471139 BC007414 BC008288 BC017113 | |
| CCDS | CCDS12129.1 CCDS54201.1 | |
| RefSeq | NP_001164562.1 NP_079517.1 | |
| UniGene | Hs.435255 | |
| ProteinModelPortal | Q9BZV1 | |
| SMR | Q9BZV1 | |
| BioGrid | 123263 | |
| IntAct | Q9BZV1 | |
| MINT | MINT-3064689 | |
| STRING | 9606.ENSP00000301281 | |
| PhosphoSite | Q9BZV1 | |
| BioMuta | UBXN6 | |
| DMDM | 30913412 | |
| MaxQB | Q9BZV1 | |
| PaxDb | Q9BZV1 | |
| PRIDE | Q9BZV1 | |
| Ensembl | ENST00000301281 ENST00000394765 | |
| GeneID | 80700 | |
| KEGG | hsa:80700 | |
| UCSC | uc002mam.2 | |
| CTD | 80700 | |
| GeneCards | GC19M004444 | |
| HGNC | HGNC:14928 | |
| HPA | HPA040906 HPA041313 | |
| MIM | 611946 | |
| neXtProt | NX_Q9BZV1 | |
| PharmGKB | PA162408446 | |
| eggNOG | NOG265523 | |
| GeneTree | ENSGT00510000047499 | |
| HOGENOM | HOG000043787 | |
| HOVERGEN | HBG061370 | |
| InParanoid | Q9BZV1 | |
| KO | K14011 | |
| OMA | QDTIRNQ | |
| PhylomeDB | Q9BZV1 | |
| TreeFam | TF314617 | |
| ChiTaRS | UBXN6 | |
| GeneWiki | UBXN6 | |
| GenomeRNAi | 80700 | |
| NextBio | 70993 | |
| PRO | PR:Q9BZV1 | |
| Proteomes | UP000005640 | |
| Bgee | Q9BZV1 | |
| CleanEx | HS_UBXN6 | |
| ExpressionAtlas | Q9BZV1 | |
| Genevisible | Q9BZV1 | |
| GO | GO:0005737 GO:0070062 GO:0005815 GO:0005730 GO:0005634 | |
| InterPro | IPR018997 IPR006567 IPR029071 IPR001012 | |
| Pfam | PF09409 PF00789 | |
| SMART | SM00580 SM00166 | |
| SUPFAM | SSF54236 | |
| PROSITE | PS50033 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005768 |
endosome |
ECO:0000314 |
C |
Figure 1c |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036503 |
ERAD pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019898 |
extrinsic component of membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016236 |
macroautophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031902 |
late endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032510 |
endosome to lysosome transport via multivesicular body sorting pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031902 |
late endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Trusch, F et al. (2015) The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97. J. Biol. Chem. 290 29414-27 PubMed GONUTS page
- ↑ 2.0 2.1 Papadopoulos, C et al. (2017) VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 36 135-150 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Nagahama, M et al. (2009) UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation. Biochem. Biophys. Res. Commun. 382 303-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Ritz, D et al. (2011) Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 13 1116-23 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
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