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HUMAN:TYSY

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TYMS (synonyms: TS)
Protein Name(s) Thymidylate synthase

TS TSase

External Links
UniProt P04818
EMBL X02308
D00596
AB077207
AB077208
AB062290
AP001178
CH471113
CH471113
BC002567
BC013919
BC083512
D00517
CCDS CCDS11821.1
PIR A23047
RefSeq NP_001062.1
UniGene Hs.369762
PDB 1HVY
1HW3
1HW4
1HZW
1I00
1JU6
1JUJ
1YPV
2ONB
2RD8
2RDA
3EAW
3EBU
3ED7
3EDW
3EF9
3EGY
3EHI
3EJL
3GG5
3GH0
3GH2
3H9K
3HB8
3N5E
3N5G
3OB7
4E28
4FGT
4G2O
4G6W
4GD7
4GYH
4H1I
4JEF
4KPW
4O1U
4O1X
4UP1
5HS3
PDBsum 1HVY
1HW3
1HW4
1HZW
1I00
1JU6
1JUJ
1YPV
2ONB
2RD8
2RDA
3EAW
3EBU
3ED7
3EDW
3EF9
3EGY
3EHI
3EJL
3GG5
3GH0
3GH2
3H9K
3HB8
3N5E
3N5G
3OB7
4E28
4FGT
4G2O
4G6W
4GD7
4GYH
4H1I
4JEF
4KPW
4O1U
4O1X
4UP1
5HS3
DisProt DP00073
ProteinModelPortal P04818
SMR P04818
BioGrid 113149
IntAct P04818
MINT MINT-2800458
STRING 9606.ENSP00000315644
BindingDB P04818
ChEMBL CHEMBL1952
DrugBank DB01101
DB00322
DB00544
DB00441
DB00650
DB00563
DB00642
DB06813
DB00293
DB00432
DB00440
GuidetoPHARMACOLOGY 2642
MoonProt P04818
iPTMnet P04818
PhosphoSite P04818
BioMuta TYMS
DMDM 136611
EPD P04818
PaxDb P04818
PRIDE P04818
TopDownProteomics P04818-1
DNASU 7298
Ensembl ENST00000323224
ENST00000323250
ENST00000323274
GeneID 7298
KEGG hsa:7298
UCSC uc010dkb.2
CTD 7298
GeneCards TYMS
HGNC HGNC:12441
HPA CAB002784
MalaCards TYMS
MIM 188350
neXtProt NX_P04818
Orphanet 240839
PharmGKB PA359
eggNOG KOG0673
COG0207
GeneTree ENSGT00390000014786
HOGENOM HOG000257899
HOVERGEN HBG001934
InParanoid P04818
KO K00560
OMA IVYELLW
OrthoDB EOG725DHX
PhylomeDB P04818
TreeFam TF353027
BioCyc MetaCyc:HS11096-MONOMER
BRENDA 2.1.1.45
Reactome R-HSA-113510
R-HSA-500753
R-HSA-69205
SABIO-RK P04818
UniPathway UPA00575
ChiTaRS TYMS
EvolutionaryTrace P04818
GeneWiki Thymidylate_synthase
GenomeRNAi 7298
NextBio 28543
PRO PR:P04818
Proteomes UP000005640
Bgee P04818
CleanEx HS_TYMS
ExpressionAtlas P04818
Genevisible P04818
GO GO:0005737
GO:0005829
GO:0005743
GO:0005759
GO:0005739
GO:0005730
GO:0005654
GO:0005634
GO:0048037
GO:0008144
GO:0005542
GO:0003729
GO:0000166
GO:0004799
GO:0007568
GO:0051216
GO:0016049
GO:0008283
GO:0007623
GO:0009157
GO:0048589
GO:0071897
GO:0006231
GO:0006235
GO:0046078
GO:0000082
GO:0019088
GO:0060574
GO:0000278
GO:0006139
GO:0055086
GO:0031100
GO:0006206
GO:0046134
GO:0000083
GO:0034097
GO:0042493
GO:0045471
GO:0051593
GO:0051384
GO:0046683
GO:0032570
GO:0009636
GO:0033189
GO:0044281
GO:0035999
GO:0019860
Gene3D 3.30.572.10
HAMAP MF_00008
InterPro IPR023451
IPR000398
IPR020940
Pfam PF00303
PRINTS PR00108
SUPFAM SSF55831
TIGRFAMs TIGR03284
PROSITE PS00091

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0004799

thymidylate synthase activity

other:GO_REF:0000100

ECO:0000255

UniProtKB:P07607


F

HHPred results yielded an E-value of 2.1e-88, an identity of 100%, a probability of 100%, and a query coverage of 97.07%.

complete
CACAO 11984

enables

GO:0000900

translation repressor activity, mRNA regulatory element binding

PMID:1924359[1]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(UniProtKB:P04818)

Seeded From UniProt

complete

enables

GO:1990825

sequence-specific mRNA binding

PMID:1924359[1]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P04818)

Seeded From UniProt

complete

involved_in

GO:0017148

negative regulation of translation

PMID:1924359[1]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P04818)

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

PMID:11278511[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

PMID:11278511[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

PMID:8845352[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

PMID:8845352[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005542

folic acid binding

PMID:15093541[4]

ECO:0000305

curator inference used in manual assertion

GO:0004799

F

Seeded From UniProt

complete

involved_in

GO:0035999

tetrahydrofolate interconversion

PMID:15093541[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

PMID:15093541[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071897

DNA biosynthetic process

PMID:15093541[4]

ECO:0000305

curator inference used in manual assertion

GO:0004799

P

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

PMID:15093541[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046683

response to organophosphorus

PMID:16079077[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:21876188[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21876188[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21876188[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21876188[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21876188[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11002
PANTHER:PTN000167391
PomBase:SPAC15E1.04
RGD:3921
SGD:S000005600
UniProtKB:P04818
UniProtKB:P9WFR9
WB:WBGene00022455
ZFIN:ZDB-GENE-040426-59

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11002
PANTHER:PTN000167391
TAIR:locus:2042649

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002610699
RGD:3921
TAIR:locus:2139544
UniProtKB:P04818

C

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11002
PANTHER:PTN000167391
PomBase:SPAC15E1.04
RGD:3921
SGD:S000005600
UniProtKB:P04818
UniProtKB:P9WFR9
WB:WBGene00022455
ZFIN:ZDB-GENE-040426-59

F

Seeded From UniProt

complete

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0060574

intestinal epithelial cell maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0051593

response to folic acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0048589

developmental growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

enables

GO:0048037

cofactor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

involved_in

GO:0046653

tetrahydrofolate metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0046078

dUMP metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0033189

response to vitamin A

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0032570

response to progesterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0019860

uracil metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0019088

immortalization of host cell by virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0006417

regulation of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0006206

pyrimidine nucleobase metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

C

Seeded From UniProt

complete

enables

GO:0005542

folic acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000398
InterPro:IPR020940

F

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000398
InterPro:IPR020940

P

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.45

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

PMID:1924359[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0015949

nucleobase-containing small molecule interconversion

Reactome:R-HSA-499943

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8962050
Reactome:R-HSA-73605

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0000083

regulation of transcription involved in G1/S transition of mitotic cell cycle

Reactome:R-HSA-69205

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0009165

nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0545

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

involved_in

GO:0006235

dTTP biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00575

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Chu, E et al. (1991) Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc. Natl. Acad. Sci. U.S.A. 88 8977-81 PubMed GONUTS page
  2. 2.0 2.1 Phan, J et al. (2001) Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. J. Biol. Chem. 276 14170-7 PubMed GONUTS page
  3. 3.0 3.1 Schiffer, CA et al. (1995) Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry 34 16279-87 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Rahman, L et al. (2004) Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 5 341-51 PubMed GONUTS page
  5. Gwinn, MR et al. (2005) Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Environ. Health Perspect. 113 1046-51 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Anderson, DD et al. (2011) Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc. Natl. Acad. Sci. U.S.A. 108 15163-8 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page