HUMAN:TTBK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TTBK1 (synonyms: BDTK, KIAA1855)
Protein Name(s)	Tau-tubulin kinase 1 Brain-derived tau kinase
External Links
UniProt	Q5TCY1
EMBL	AB218664 AK131217 AL133375 AL133375 AB058758 BC036764
CCDS	CCDS34455.1
RefSeq	NP_115927.1
UniGene	Hs.485436
PDB	4BTJ 4BTK 4BTM 4NFM 4NFN
PDBsum	4BTJ 4BTK 4BTM 4NFM 4NFN
ProteinModelPortal	Q5TCY1
SMR	Q5TCY1
BioGrid	124159
STRING	9606.ENSP00000259750
ChEMBL	CHEMBL1926492
PhosphoSite	Q5TCY1
DMDM	97203020
PaxDb	Q5TCY1
PRIDE	Q5TCY1
DNASU	84630
Ensembl	ENST00000259750
GeneID	84630
KEGG	hsa:84630
UCSC	uc003ouq.1
CTD	84630
GeneCards	GC06P043259
H-InvDB	HIX0005900
HGNC	HGNC:19140
HPA	HPA031736
neXtProt	NX_Q5TCY1
PharmGKB	PA134866142
eggNOG	COG0515
GeneTree	ENSGT00760000119040
HOGENOM	HOG000154701
HOVERGEN	HBG094095
InParanoid	Q5TCY1
KO	K08815
OMA	VLTAPCK
OrthoDB	EOG7RFTGM
PhylomeDB	Q5TCY1
TreeFam	TF351646
SignaLink	Q5TCY1
ChiTaRS	TTBK1
GenomeRNAi	84630
NextBio	74547
PRO	PR:Q5TCY1
Proteomes	UP000005640
Bgee	Q5TCY1
CleanEx	HS_TTBK1
ExpressionAtlas	Q5TCY1
Genevestigator	Q5TCY1
GO	GO:0005737 GO:0005524 GO:0004674 GO:0021762
InterPro	IPR011009 IPR000719 IPR017441
Pfam	PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016301	kinase activity	PMID:17344846^[1]	ECO:0000314			F		Seeded From UniProt Figure 3. The difference in selection pressure between ten protein kinase. Previous kinases were linked to cancer genes such as tyrosine kinase and serine/threonine kinases. Evidence proves that other subclasses of kinases are contributing to the development of cancer.	complete CACAO 9370
Contributes to	GO:0005737	cytoplasm	PMID:17344846^[1]	ECO:0000247		UniProtKB:Q5TCY1	C		Mis-sense mutations in the activation p-Loop give rise to patterns of somatic mutation in human cancer genomes	complete CACAO 9380
part_of	GO:0043025	neuronal cell body	PMID:16923168^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000273079) regulates_o_occurs_in:(UBERON:0002421)\|regulates_expression_of(ENSEMBL:ENSG00000105464) regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15078) has_regulation_target:(UniProtKB:P60709)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0061890	positive regulation of astrocyte activation	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0000411)	Seeded From UniProt	complete
involved_in	GO:1903980	positive regulation of microglial cell activation	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002421)\|regulates_o_occurs_in:(UBERON:0000411)	Seeded From UniProt	complete
involved_in	GO:0032273	positive regulation of protein polymerization	PMID:16923168^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:16923168^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10636) positively_regulates:(GO:0051258)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16923168^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10636) positively_regulates:(GO:0051258)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:16923168^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:16923168^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6PCN3	C	part_of:(CL:0000598) part_of:(UBERON:0016538)\|part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0018105,GO:0018107,GO:0018108,GO:0032273,GO:0043025,GO:0048471	C	part_of:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1904031	positive regulation of cyclin-dependent protein kinase activity	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q00535)	Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	activated_by:(CHEBI:22984) has_regulation_target:(UniProtKB:P07384)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000176749) positively_regulates:(GO:0030295)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19118186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0021762	substantia nigra development	PMID:22926577^[5]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002628887 UniProtKB:Q5TCY1	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027889 PANTHER:PTN002628885 SGD:S000002175 UniProtKB:Q5TCY1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2155779 PANTHER:PTN002628885 RGD:71098 SGD:S000002175 UniProtKB:P35507 UniProtKB:P35508 UniProtKB:P48729 UniProtKB:P48730 UniProtKB:P49674 UniProtKB:P67827 UniProtKB:P78368 UniProtKB:Q5TCY1 UniProtKB:Q6IQ55 UniProtKB:Q9HCP0 UniProtKB:Q9Y6M4 ZFIN:ZDB-GENE-020419-19	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002413 FB:FBgn0015024 FB:FBgn0030384 FB:FBgn0031441 FB:FBgn0032650 FB:FBgn0037325 FB:FBgn0039908 PANTHER:PTN000225966 PomBase:SPBP35G2.05c RGD:62045 RGD:71098 TAIR:locus:2018269 TAIR:locus:2024147 TAIR:locus:2030170 TAIR:locus:2117778 TAIR:locus:2117843 TAIR:locus:2129640 TAIR:locus:504954933 UniProtKB:C8V7X8 UniProtKB:O00311 UniProtKB:P49674 UniProtKB:Q86Y07 WB:WBGene00002202 WB:WBGene00013709 dictyBase:DDB_G0273059	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002413 FB:FBgn0015024 FB:FBgn0027889 FB:FBgn0030384 MGI:MGI:1261847 MGI:MGI:1351660 MGI:MGI:1355272 MGI:MGI:2182465 PANTHER:PTN000225966 PomBase:SPBC776.12c RGD:62045 RGD:71098 SGD:S000000925 SGD:S000002175 SGD:S000006125 TAIR:locus:2024147 TAIR:locus:2030170 TAIR:locus:2117778 TAIR:locus:2117843 TAIR:locus:2129640 UniProtKB:A0A0B4KHL4 UniProtKB:C8V7X8 UniProtKB:C8VHB6 UniProtKB:O00311 UniProtKB:Q6IQ55 UniProtKB:Q6K9N1 UniProtKB:Q852L0 UniProtKB:Q86Y07 UniProtKB:Q8IV63 UniProtKB:Q99986 WB:WBGene00002202 WB:WBGene00017895 dictyBase:DDB_G0273059	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002413 FB:FBgn0015024 FB:FBgn0031441 FB:FBgn0032650 FB:FBgn0037325 MGI:MGI:1261847 MGI:MGI:1917172 MGI:MGI:2155779 PANTHER:PTN002628885 PomBase:SPAC23C4.12 PomBase:SPBC1347.06c PomBase:SPBC3H7.15 PomBase:SPBC776.12c RGD:62045 RGD:621404 RGD:621407 RGD:621408 RGD:71031 RGD:71098 SGD:S000001177 SGD:S000002175 SGD:S000005098 SGD:S000006125 TAIR:locus:2091566 TAIR:locus:2117843 TAIR:locus:2121338 TAIR:locus:2129640 TAIR:locus:2130290 UniProtKB:A0A0B4KHL4 UniProtKB:P35507 UniProtKB:P35508 UniProtKB:P48729 UniProtKB:P48730 UniProtKB:P49674 UniProtKB:P67827 UniProtKB:P78368 UniProtKB:Q6IQ55 UniProtKB:Q86Y07 UniProtKB:Q8IHZ9 UniProtKB:Q99986 UniProtKB:Q9HCP0 UniProtKB:Q9Y6M4 dictyBase:DDB_G0273059	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6PCN3 ensembl:ENSMUSP00000044580	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6PCN3 ensembl:ENSMUSP00000044580	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Greenman, C et al. (2007) Patterns of somatic mutation in human cancer genomes. Nature 446 153-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sato, S et al. (2006) Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 98 1573-84 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Sato, S et al. (2008) Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J. Neurosci. 28 14511-21 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17344846-1] 1.0 ^1.1 Greenman, C et al. (2007) Patterns of somatic mutation in human cancer genomes. Nature 446 153-8 PubMed GONUTS page

[PMID:16923168-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sato, S et al. (2006) Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 98 1573-84 PubMed GONUTS page

[PMID:19118186-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Sato, S et al. (2008) Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J. Neurosci. 28 14511-21 PubMed GONUTS page

[PMID:28386764-4] 4.0 ^4.1 ^4.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:22926577-5] Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:TTBK1

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References

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