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HUMAN:TRPC1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRPC1 (synonyms: TRP1)
Protein Name(s) Short transient receptor potential channel 1

TrpC1 Transient receptor protein 1 TRP-1

External Links
UniProt P48995
EMBL U31110
U31110
X89066
Z73903
CH471052
BC112338
BC113953
CCDS CCDS3126.1
CCDS58856.1
PIR S68238
RefSeq NP_001238774.1
NP_003295.1
UniGene Hs.250687
Hs.684389
ProteinModelPortal P48995
BioGrid 113071
DIP DIP-35698N
IntAct P48995
STRING 9606.ENSP00000273481
GuidetoPHARMACOLOGY 486
TCDB 1.A.4.1.3
PhosphoSite P48995
DMDM 1351302
PaxDb P48995
PRIDE P48995
Ensembl ENST00000273482
ENST00000476941
ENST00000612385
GeneID 7220
KEGG hsa:7220
UCSC uc003evb.3
uc003evc.3
CTD 7220
GeneCards GC03P142440
HGNC HGNC:12333
HPA CAB009387
HPA021130
MIM 602343
neXtProt NX_P48995
PharmGKB PA357
eggNOG NOG245138
GeneTree ENSGT00760000119180
HOGENOM HOG000020589
HOVERGEN HBG068337
InParanoid P48995
KO K04964
OMA VKEETTL
OrthoDB EOG72G17P
PhylomeDB P48995
TreeFam TF313147
Reactome REACT_118700
REACT_169333
REACT_22228
ChiTaRS TRPC1
GeneWiki TRPC1
GenomeRNAi 7220
NextBio 28276
PRO PR:P48995
Proteomes UP000005640
Bgee P48995
CleanEx HS_TRPC1
Genevestigator P48995
GO GO:0016323
GO:0043034
GO:0005887
GO:0045121
GO:0005886
GO:0043235
GO:0030017
GO:0005262
GO:0005261
GO:0070679
GO:0044325
GO:0015279
GO:0007411
GO:0070588
GO:0006816
GO:0051480
GO:0034220
GO:0051281
GO:0051592
GO:0046541
GO:0055085
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR005821
IPR004729
IPR013555
IPR005457
IPR002153
PANTHER PTHR10117
PTHR10117:SF3
Pfam PF12796
PF00520
PF08344
PRINTS PR01097
PR01642
SMART SM00248
SUPFAM SSF48403
TIGRFAMs TIGR00870

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042438

melanin biosynthetic process

PMID:8126111[1]

ECO:0000314

P

Based on the results in fig 5.

complete
CACAO 2235

involved_in

GO:0042438

melanin biosynthetic process

PMID:8126111[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:8663995[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070679

inositol 1,4,5 trisphosphate binding

PMID:14505576[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

PMID:19052258[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

PMID:14505576[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051480

regulation of cytosolic calcium ion concentration

PMID:19052258[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

PMID:19052258[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14505576[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070679

inositol 1,4,5 trisphosphate binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109524
MGI:MGI:109525
MGI:MGI:109527
PANTHER:PTN000012230
UniProtKB:P48995
UniProtKB:Q13507
UniProtKB:Q9Y210

F

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003861
FB:FBgn0005614
PANTHER:PTN000012230
UniProtKB:Q13507

P

Seeded From UniProt

complete

involved_in

GO:0051480

regulation of cytosolic calcium ion concentration

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012230
UniProtKB:P48995

P

Seeded From UniProt

complete

part_of

GO:0034703

cation channel complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003861
FB:FBgn0005614
FB:FBgn0032593
PANTHER:PTN000012230

C

Seeded From UniProt

complete

enables

GO:0015279

store-operated calcium channel activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109523
MGI:MGI:109525
MGI:MGI:109527
MGI:MGI:109528
PANTHER:PTN000012230
UniProtKB:Q9UBN4
WB:WBGene00004976

F

Seeded From UniProt

complete

involved_in

GO:0006828

manganese ion transport

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349470
PANTHER:PTN000012230

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012230
RGD:621276
UniProtKB:Q13507
WB:WBGene00004976

C

Seeded From UniProt

complete

enables

GO:0005261

cation channel activity

PMID:18995841[6]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:23382219[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

F

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002153
InterPro:IPR005457

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002153
InterPro:IPR005821

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005457

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002153
InterPro:IPR005457

P

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

PMID:10097141[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13563

F

Seeded From UniProt

complete

enables

GO:0015279

store-operated calcium channel activity

PMID:8663995[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

PMID:8646775[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7568191[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

PMID:8646775[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1903779

regulation of cardiac conduction

Reactome:R-HSA-5578775

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

Reactome:R-HSA-3295583

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-3295579
Reactome:R-HSA-2089943
Reactome:R-HSA-2089927

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

P

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0109

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Abdel-Malek, Z et al. (1993) Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes. J. Cell. Sci. 106 ( Pt 4) 1323-31 PubMed GONUTS page
  2. ↑ 2.0 2.1 Zitt, C et al. (1996) Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron 16 1189-96 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Yuan, JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 777-89 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Sundivakkam, PC et al. (2009) Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am. J. Physiol., Cell Physiol. 296 C403-13 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Zeng, W et al. (2008) STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol. Cell 32 439-48 PubMed GONUTS page
  7. ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
  8. ↑ Tsiokas, L et al. (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U.S.A. 96 3934-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 Zhu, X et al. (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85 661-71 PubMed GONUTS page
  10. ↑ Wes, PD et al. (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc. Natl. Acad. Sci. U.S.A. 92 9652-6 PubMed GONUTS page
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