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PMID:8646775

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Citation

Zhu, X, Jiang, M, Peyton, M, Boulay, G, Hurst, R, Stefani, E and Birnbaumer, L (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85:661-71

Abstract

SUMMARY: Capacitative calcium entry (CCE) describes CA2+ influx into cells that replenishes CA2+ stores emptied through the action of IP3 and other agents. It is an essential component of cellular responses to many hormones and growth factors. The molecular basis of this form of Ca2+ entry is complex and may involve more than one type of channel. Studies on visual signal transduction in Drosophila led to the hypothesis that a protein encoded in trp may be a component of CCE channels. We reported the existence of six trp-related genes in the mouse genome. Expression in L cells of small portions of these genes in antisense orientation suppressed CCE. Expression in COS cells of two full-length cDNAs encoding human trp homologs, Htrp1 and Htrp3, increased CCE. This identifies mammalian gene products that participate in CCE. We propose that trp homologs are subunits of CCE channels, not unlike those of classical voltage-gated ion channels.

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PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Calcium/metabolism; Calcium Channels/chemistry; Calcium Channels/genetics; Calcium Channels/metabolism; Cloning, Molecular; DNA Primers/genetics; DNA, Antisense/genetics; DNA, Antisense/pharmacology; Drosophila; Gene Expression; Genetic Variation; Humans; Ion Transport; L Cells (Cell Line); Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Multigene Family; Protein Conformation; RNA, Messenger/genetics; RNA, Messenger/metabolism; TRPC Cation Channels; Tissue Distribution

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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References

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