HUMAN:TNR11

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TNFRSF11A (synonyms: RANK)
Protein Name(s)	Tumor necrosis factor receptor superfamily member 11A Osteoclast differentiation factor receptor ODFR Receptor activator of NF-KB
External Links
UniProt	Q9Y6Q6
EMBL	AF018253 HF584702 HE647782 HE649916 HE649917 HE659518 AB209762
CCDS	CCDS11980.1 CCDS59324.1 CCDS74227.1 CCDS74228.1
RefSeq	NP_001257878.1 NP_001257879.1 NP_001257880.1 NP_001265197.1 NP_003830.1 XP_005266834.1
UniGene	Hs.204044 Hs.621477
PDB	1LB5
PDBsum	1LB5
ProteinModelPortal	Q9Y6Q6
SMR	Q9Y6Q6
BioGrid	114320
IntAct	Q9Y6Q6
STRING	9606.ENSP00000269485
GuidetoPHARMACOLOGY	1881
PhosphoSite	Q9Y6Q6
DMDM	19924309
MaxQB	Q9Y6Q6
PaxDb	Q9Y6Q6
PRIDE	Q9Y6Q6
DNASU	8792
Ensembl	ENST00000269485 ENST00000586569 ENST00000616710 ENST00000617039
GeneID	8792
KEGG	hsa:8792
UCSC	uc002lin.4
CTD	8792
GeneCards	GC18P059992
HGNC	HGNC:11908
HPA	CAB010391 HPA027728
MIM	174810 602080 603499 612301
neXtProt	NX_Q9Y6Q6
Orphanet	85195 178389
PharmGKB	PA36601
eggNOG	NOG45473
GeneTree	ENSGT00760000119204
HOGENOM	HOG000154659
HOVERGEN	HBG079274
InParanoid	Q9Y6Q6
KO	K05147
OMA	CPHWAAS
OrthoDB	EOG786H2Q
PhylomeDB	Q9Y6Q6
SignaLink	Q9Y6Q6
ChiTaRS	TNFRSF11A
GeneWiki	RANK
GenomeRNAi	8792
NextBio	32972
PRO	PR:Q9Y6Q6
Proteomes	UP000005640
Bgee	Q9Y6Q6
CleanEx	HS_TNFRSF11A
Genevestigator	Q9Y6Q6
GO	GO:0009897 GO:0016021 GO:0019955 GO:0046872 GO:0004872 GO:0004888 GO:0005031 GO:0002250 GO:0007267 GO:0060086 GO:0048535 GO:0060749 GO:0002548 GO:0001503 GO:0030316 GO:0008284 GO:0071848 GO:0071812 GO:0043507 GO:0051092 GO:0051091 GO:0034097 GO:0070555 GO:0032496 GO:0009314 GO:0034612 GO:0007165 GO:0071847 GO:0033209
InterPro	IPR001368 IPR022323 IPR022361
Pfam	PF00020
PRINTS	PR01961 PR01974
SMART	SM00208
PROSITE	PS00652 PS50050

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	PMID:18606301^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071847	TNFSF11-mediated signaling pathway	PMID:18606301^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0060086	circadian temperature homeostasis	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12296995^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:9367155^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:12296995^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:12296995^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:18606301^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	P	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	PMID:18606301^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:9367155^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35235	F	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:9367155^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005031	tumor necrosis factor-activated receptor activity	PMID:19940926^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35305	F	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:9367155^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:15248232^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:18606301^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M8Z6 ensembl:ENSRNOP00000021129	P	Seeded From UniProt	complete
involved_in	GO:0072674	multinuclear osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0060749	mammary gland alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0060086	circadian temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0048535	lymph node development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
enables	GO:0005031	tumor necrosis factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	F	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35305 ensembl:ENSMUSP00000027559	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:9367155^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:9367155^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9367155^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:9367155^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5676594 Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5676595 Reactome:R-HSA-5676592 Reactome:R-HSA-5676589 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668414	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Guerrini, MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am. J. Hum. Genet. 83 64-76 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lee, SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J. Biochem. Mol. Biol. 35 371-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Anderson, DM et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 175-9 PubMed GONUTS page
↑ Mosheimer, BA et al. (2004) Expression and function of RANK in human monocyte chemotaxis. Arthritis Rheum. 50 2309-16 PubMed GONUTS page

[PMID:18606301-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Guerrini, MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am. J. Hum. Genet. 83 64-76 PubMed GONUTS page

[PMID:19940926-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page

[PMID:12296995-3] 3.0 ^3.1 ^3.2 Lee, SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J. Biochem. Mol. Biol. 35 371-6 PubMed GONUTS page

[PMID:9367155-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Anderson, DM et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 175-9 PubMed GONUTS page

[PMID:15248232-5] Mosheimer, BA et al. (2004) Expression and function of RANK in human monocyte chemotaxis. Arthritis Rheum. 50 2309-16 PubMed GONUTS page

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HUMAN:TNR11

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