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PMID:9367155

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Citation

Anderson, DM, Maraskovsky, E, Billingsley, WL, Dougall, WC, Tometsko, ME, Roux, ER, Teepe, MC, DuBose, RF, Cosman, D and Galibert, L (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175-9

Abstract

Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity. Several members of the tumour necrosis factor receptor (TNFR) superfamily are integral to the regulation of the immune response. These structurally related proteins modulate cellular functions ranging from proliferation and differentiation to inflammation and cell survival or deaths. The functional activity of dendritic cells is greatly increased by signalling through the TNFR family member CD40. Here we report the characterization of RANK (for receptor activator of NF-kappaB), a new member of the TNFR family derived from dendritic cells, and the isolation of a RANK ligand (RANKL) by direct expression screening. RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, and increases the survival of RANK+ T cells generated with interleukin-4 and transforming growth factor (TGF)-beta. Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.

Links

PubMed Online version:10.1038/36593

Keywords

Amino Acid Sequence; Animals; CD40 Ligand; Carrier Proteins; Cell Line; Cells, Cultured; Chromosome Mapping; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 18; Dendritic Cells/immunology; Humans; Ligands; Membrane Glycoproteins/metabolism; Membrane Proteins/metabolism; Mice; Molecular Sequence Data; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Tumor Necrosis Factor/analysis; Receptors, Tumor Necrosis Factor/genetics; Receptors, Tumor Necrosis Factor/immunology; Sequence Homology, Amino Acid; T-Lymphocytes/immunology; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:TNF11

enables

GO:0032813: tumor necrosis factor receptor superfamily binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Y6Q6

F

Seeded From UniProt

complete

HUMAN:TNR11

located_in

GO:0009897: external side of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TNR11

involved_in

GO:0008284: positive regulation of cell population proliferation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNR11

involved_in

GO:0007267: cell-cell signaling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNR11

involved_in

GO:0007165: signal transduction

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNR11

enables

GO:0038023: signaling receptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TNR11

enables

GO:0004888: transmembrane signaling receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TNR11

part_of

GO:0009897: external side of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TNR11

enables

GO:0019955: cytokine binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O35235

F

Seeded From UniProt

complete

HUMAN:TNR11

involved_in

GO:0051092: positive regulation of NF-kappaB transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNF11

enables

GO:0005164: tumor necrosis factor receptor binding

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TNF11

enables

GO:0005125: cytokine activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TNF11

involved_in

GO:0034112: positive regulation of homotypic cell-cell adhesion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNF11

involved_in

GO:0050870: positive regulation of T cell activation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TNF11

involved_in

GO:0051092: positive regulation of NF-kappaB transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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