HUMAN:TNKS2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TNKS2 (synonyms: PARP5B, TANK2, TNKL)
Protein Name(s)	Tankyrase-2 TANK2 ADP-ribosyltransferase diphtheria toxin-like 6 ARTD6 Poly [ADP-ribose] polymerase 5B TNKS-2 TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Tankyrase II Tankyrase-like protein Tankyrase-related protein
External Links
UniProt	Q9H2K2
EMBL	AF305081 AF264912 AF329696 AF342982 AF309033 AF438201 AK023746 AK314612 AL359707
CCDS	CCDS7417.1
RefSeq	NP_079511.1
UniGene	Hs.329327
PDB	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI
PDBsum	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI
ProteinModelPortal	Q9H2K2
SMR	Q9H2K2
BioGrid	123257
DIP	DIP-42098N
IntAct	Q9H2K2
MINT	MINT-1183420
STRING	9606.ENSP00000360689
BindingDB	Q9H2K2
ChEMBL	CHEMBL3038515
PhosphoSite	Q9H2K2
DMDM	20140805
MaxQB	Q9H2K2
PaxDb	Q9H2K2
PRIDE	Q9H2K2
DNASU	80351
Ensembl	ENST00000371627
GeneID	80351
KEGG	hsa:80351
UCSC	uc001khp.3
CTD	80351
GeneCards	GC10P093548
HGNC	HGNC:15677
HPA	HPA036606
MIM	607128
neXtProt	NX_Q9H2K2
PharmGKB	PA38019
eggNOG	COG0666
GeneTree	ENSGT00760000118950
HOGENOM	HOG000246964
HOVERGEN	HBG059472
InParanoid	Q9H2K2
KO	K10799
OMA	NSDADRQ
OrthoDB	EOG7N8ZTP
PhylomeDB	Q9H2K2
TreeFam	TF326036
Reactome	REACT_200766 REACT_200777 REACT_228279
ChiTaRS	TNKS2
EvolutionaryTrace	Q9H2K2
GeneWiki	TNKS2
GenomeRNAi	80351
NextBio	70966
PRO	PR:Q9H2K2
Proteomes	UP000005640
Bgee	Q9H2K2
CleanEx	HS_TNKS2
Genevestigator	Q9H2K2
GO	GO:0005737 GO:0000139 GO:0000784 GO:0005635 GO:0005634 GO:0000242 GO:0048471 GO:0019899 GO:0046872 GO:0003950 GO:0035264 GO:0090263 GO:0032212 GO:0006471 GO:0070213 GO:0070198 GO:0000209 GO:0040014 GO:0016055
Gene3D	1.10.150.50 1.25.40.20 3.90.228.10
InterPro	IPR002110 IPR020683 IPR012317 IPR001660 IPR013761 IPR011510
Pfam	PF00023 PF12796 PF00644 PF07647
PRINTS	PR01415
SMART	SM00248 SM00454
SUPFAM	SSF47769 SSF48403
PROSITE	PS50297 PS50088 PS51059 PS50105

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070212	protein poly-ADP-ribosylation	PMID:25043379^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990404	protein ADP-ribosylase activity	PMID:25043379^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	PMID:25939383^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	PMID:25939383^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:25939383^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	PMID:21531765^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070198	protein localization to chromosome, telomeric region	PMID:11739745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11454873^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:11739745^[4]	ECO:0000305	curator inference used in manual assertion	GO:0070198	P	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:11739745^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11278563^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:11454873^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11739745^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:11739745^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:11739745^[4]	ECO:0000305	curator inference used in manual assertion	GO:0070198	C	Seeded From UniProt	complete
part_of	GO:0000242	pericentriolar material	PMID:11454873^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:19759537^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070213	protein auto-ADP-ribosylation	PMID:21478859^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070213	protein auto-ADP-ribosylation	PMID:19759537^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21251231^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NWT6	F	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:21478859^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:19759537^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21478859^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:19759537^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652929 UniProtKB:O95271 UniProtKB:Q9H2K2	P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027508 PANTHER:PTN000652929 UniProtKB:O95271 UniProtKB:Q9H2K2	P	Seeded From UniProt	complete
involved_in	GO:0070198	protein localization to chromosome, telomeric region	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652929 UniProtKB:O95271 UniProtKB:Q9H2K2	P	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027508 PANTHER:PTN000652929 UniProtKB:O95271 UniProtKB:Q9H2K2	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652929 UniProtKB:Q9H2K2	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652929 UniProtKB:Q9H2K2	C	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027508 PANTHER:PTN000652929 UniProtKB:O95271 UniProtKB:Q9H2K2	F	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UES3 ensembl:ENSMUSP00000025729	P	Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UES3 ensembl:ENSMUSP00000025729	P	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012317	F	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.2.30	F	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641257	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8948800 Reactome:R-HSA-5262606 Reactome:R-HSA-3640874 Reactome:R-HSA-3640872 Reactome:R-HSA-3640862 Reactome:R-HSA-3640861 Reactome:R-HSA-3640858 Reactome:R-HSA-3640844	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	Reactome:R-HSA-3640858	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vyas, S et al. (2014) Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun 5 4426 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kulak, O et al. (2015) Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol. Cell. Biol. 35 2425-35 PubMed GONUTS page
↑ Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Cook, BD et al. (2002) Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell. Biol. 22 332-42 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kaminker, PG et al. (2001) TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J. Biol. Chem. 276 35891-9 PubMed GONUTS page
↑ Lyons, RJ et al. (2001) Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. J. Biol. Chem. 276 17172-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Huang, SM et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-20 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zhang, Y et al. (2011) RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat. Cell Biol. 13 623-9 PubMed GONUTS page
↑ Yang, M et al. (2011) Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. FEBS J. 278 1086-97 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25043379-1] 1.0 ^1.1 Vyas, S et al. (2014) Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun 5 4426 PubMed GONUTS page

[PMID:25939383-2] 2.0 ^2.1 ^2.2 Kulak, O et al. (2015) Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol. Cell. Biol. 35 2425-35 PubMed GONUTS page

[PMID:21531765-3] Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:11739745-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Cook, BD et al. (2002) Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell. Biol. 22 332-42 PubMed GONUTS page

[PMID:11454873-5] 5.0 ^5.1 ^5.2 Kaminker, PG et al. (2001) TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J. Biol. Chem. 276 35891-9 PubMed GONUTS page

[PMID:11278563-6] Lyons, RJ et al. (2001) Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. J. Biol. Chem. 276 17172-80 PubMed GONUTS page

[PMID:19759537-7] 7.0 ^7.1 ^7.2 ^7.3 Huang, SM et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-20 PubMed GONUTS page

[PMID:21478859-8] 8.0 ^8.1 ^8.2 Zhang, Y et al. (2011) RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat. Cell Biol. 13 623-9 PubMed GONUTS page

[PMID:21251231-9] Yang, M et al. (2011) Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. FEBS J. 278 1086-97 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:TNKS2

Contents

Annotations

Notes

References

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