HUMAN:TNAP3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TNFAIP3 (synonyms: OTUD7C)
Protein Name(s)	Tumor necrosis factor alpha-induced protein 3 TNF alpha-induced protein 3 OTU domain-containing protein 7C Putative DNA-binding protein A20 Zinc finger protein A20 A20p50 A20p37
External Links
UniProt	P21580
EMBL	M59465 AK312862 AY248754 AL357060 CH471051 CH471051 BC113871 BC114480 AL157444
CCDS	CCDS5187.1
PIR	A35797
RefSeq	NP_001257436.1 NP_001257437.1 NP_006281.1 XP_005267176.1
UniGene	Hs.211600
PDB	2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG
PDBsum	2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG
ProteinModelPortal	P21580
SMR	P21580
BioGrid	112983
DIP	DIP-33804N
IntAct	P21580
MINT	MINT-97330
STRING	9606.ENSP00000237289
MEROPS	C64.003
PhosphoSite	P21580
DMDM	112894
MaxQB	P21580
PaxDb	P21580
PRIDE	P21580
Ensembl	ENST00000237289 ENST00000612899
GeneID	7128
KEGG	hsa:7128
UCSC	uc003qhr.4
CTD	7128
GeneCards	GC06P138188
HGNC	HGNC:11896
HPA	HPA002116
MIM	191163
neXtProt	NX_P21580
Orphanet	536
PharmGKB	PA36593
eggNOG	NOG248343
GeneTree	ENSGT00530000062989
HOGENOM	HOG000133004
HOVERGEN	HBG059260
InParanoid	P21580
KO	K11859
OMA	CETPNCP
OrthoDB	EOG7JHM57
PhylomeDB	P21580
TreeFam	TF323312
Reactome	REACT_25271 REACT_75776
SignaLink	P21580
ChiTaRS	TNFAIP3
EvolutionaryTrace	P21580
GeneWiki	TNFAIP3
GenomeRNAi	7128
NextBio	27895
PRO	PR:P21580
Proteomes	UP000005640
Bgee	P21580
CleanEx	HS_TNFAIP3
ExpressionAtlas	P21580
Genevestigator	P21580
GO	GO:0005813 GO:0005737 GO:0005829 GO:0070062 GO:0005764 GO:0005634 GO:0003677 GO:0016874 GO:0002020 GO:0043621 GO:0043130 GO:0004221 GO:0004842 GO:0004843 GO:0008270 GO:0006915 GO:0001922 GO:0070301 GO:0071222 GO:0006954 GO:0045087 GO:0050869 GO:0045779 GO:2000349 GO:2000352 GO:1902042 GO:0043124 GO:0050728 GO:0045824 GO:0032703 GO:0032715 GO:0032088 GO:0090291 GO:0031397 GO:0048662 GO:0034136 GO:0034140 GO:0034144 GO:0032720 GO:0032480 GO:0035872 GO:0070423 GO:0045732 GO:0016579 GO:0035871 GO:0071108 GO:0070936 GO:0070536 GO:0051259 GO:0050691 GO:0002634 GO:0061043 GO:0002237 GO:0072573
InterPro	IPR003323 IPR002653
Pfam	PF02338 PF01754
SMART	SM00259
PROSITE	PS50802 PS51036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:20458337^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:12885753^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000349	negative regulation of CD40 signaling pathway	PMID:12885753^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:12167698^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090291	negative regulation of osteoclast proliferation	PMID:21127049^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072573	tolerance induction to lipopolysaccharide	PMID:21220427^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:19912257^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21220427^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21127049^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061043	regulation of vascular wound healing	PMID:16816117^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:15474016^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050869	negative regulation of B cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0050691	regulation of defense response to virus by host	PMID:15142865^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:16816117^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	PMID:21127049^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21127049^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:8797804^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:15474016^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:19285159^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0CG48	F		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21127049^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	PMID:15142865^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	PMID:15474016^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	PMID:15142865^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	PMID:18223652^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:18223652^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:20392859^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002634	regulation of germinal center formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	PMID:19912257^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:18223652^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UDY8	F		Seeded From UniProt	complete
involved_in	GO:0001922	B-1 B cell homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:11463333^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11463333^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	PMID:23827681^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:15258597^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	PMID:15258597^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0045824	negative regulation of innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60769	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:15258597^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035871	protein K11-linked deubiquitination	PMID:23827681^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:23827681^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:15258597^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:15258597^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:15258597^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1990168	protein K33-linked deubiquitination	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001001090 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:Q9UGI0	F		Seeded From UniProt	complete
involved_in	GO:0035523	protein K29-linked deubiquitination	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037734 PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196377 MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:Q6GQQ9 UniProtKB:Q9UGI0	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001001090 UniProtKB:P21580 UniProtKB:Q6GQQ9 UniProtKB:Q9UGI0	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:P21580 UniProtKB:Q6GQQ9 UniProtKB:Q8TE49 UniProtKB:Q9UGI0	F		Seeded From UniProt	complete
enables	GO:0061578	Lys63-specific deubiquitinase activity	PMID:14748687^[18]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050713	negative regulation of interleukin-1 beta secretion	PMID:28094437^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:30561431^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000347	positive regulation of hepatocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:1903364	positive regulation of cellular protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0072666	establishment of protein localization to vacuole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0050869	negative regulation of B cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0045824	negative regulation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	C		Seeded From UniProt	complete
involved_in	GO:0002677	negative regulation of chronic inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0002634	regulation of germinal center formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
involved_in	GO:0001922	B-1 B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60769 ensembl:ENSMUSP00000019997	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002653	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002653	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033478	P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033478	P		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:20392859^[13] Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:20392859^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:R-HSA-168638	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061578	Lys63-specific deubiquitinase activity	Reactome:R-HSA-8869506 Reactome:R-HSA-5690856	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032480	negative regulation of type I interferon production	Reactome:R-HSA-936440	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5357905	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-937337 Reactome:R-HSA-8869506 Reactome:R-HSA-688136 Reactome:R-HSA-5693108 Reactome:R-HSA-5693055 Reactome:R-HSA-5690870 Reactome:R-HSA-5690856 Reactome:R-HSA-5690845 Reactome:R-HSA-5690827 Reactome:R-HSA-5357845	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Longo, CR et al. (2003) A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation 108 1113-8 PubMed GONUTS page
↑ He, KL & Ting, AT (2002) A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol. Cell. Biol. 22 6034-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Mabilleau, G et al. (2011) Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis. J. Biol. Chem. 286 3242-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Xiong, Y et al. (2011) Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J. Biol. Chem. 286 7905-16 PubMed GONUTS page
↑ ^6.0 ^6.1 Oshima, N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 159 185-98 PubMed GONUTS page
↑ ^7.0 ^7.1 Patel, VI et al. (2006) A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J. 20 1418-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wang, YY et al. (2004) A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 576 86-90 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Gon, Y et al. (2004) A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 31 330-6 PubMed GONUTS page
↑ De Valck, D et al. (1996) A20, an inhibitor of cell death, self-associates by its zinc finger domain. FEBS Lett. 384 61-4 PubMed GONUTS page
↑ Fenner, BJ et al. (2009) Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim. Biophys. Acta 1794 1010-6 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Coornaert, B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat. Immunol. 9 263-71 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Ning, S & Pagano, JS (2010) The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J. Virol. 84 6130-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Evans, PC et al. (2001) Isolation and characterization of two novel A20-like proteins. Biochem. J. 357 617-23 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Mevissen, TE et al. (2013) OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154 169-84 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Wertz, IE et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430 694-9 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Evans, PC et al. (2004) Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem. J. 378 727-34 PubMed GONUTS page
↑ Lee, JY et al. (2017) The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein. FEBS Lett. 591 479-490 PubMed GONUTS page
↑ Van Quickelberghe, E et al. (2018) A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Sci Data 5 180289 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:20458337-1] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:12885753-2] 2.0 ^2.1 Longo, CR et al. (2003) A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation 108 1113-8 PubMed GONUTS page

[PMID:12167698-3] He, KL & Ting, AT (2002) A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol. Cell. Biol. 22 6034-45 PubMed GONUTS page

[PMID:21127049-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Mabilleau, G et al. (2011) Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis. J. Biol. Chem. 286 3242-9 PubMed GONUTS page

[PMID:21220427-5] 5.0 ^5.1 Xiong, Y et al. (2011) Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J. Biol. Chem. 286 7905-16 PubMed GONUTS page

[PMID:19912257-6] 6.0 ^6.1 Oshima, N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 159 185-98 PubMed GONUTS page

[PMID:16816117-7] 7.0 ^7.1 Patel, VI et al. (2006) A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J. 20 1418-30 PubMed GONUTS page

[PMID:15474016-8] 8.0 ^8.1 ^8.2 Wang, YY et al. (2004) A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 576 86-90 PubMed GONUTS page

[PMID:15142865-9] 9.0 ^9.1 ^9.2 Gon, Y et al. (2004) A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 31 330-6 PubMed GONUTS page

[PMID:8797804-10] De Valck, D et al. (1996) A20, an inhibitor of cell death, self-associates by its zinc finger domain. FEBS Lett. 384 61-4 PubMed GONUTS page

[PMID:19285159-11] Fenner, BJ et al. (2009) Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim. Biophys. Acta 1794 1010-6 PubMed GONUTS page

[PMID:18223652-12] 12.0 ^12.1 ^12.2 Coornaert, B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat. Immunol. 9 263-71 PubMed GONUTS page

[PMID:20392859-13] 13.0 ^13.1 ^13.2 Ning, S & Pagano, JS (2010) The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J. Virol. 84 6130-8 PubMed GONUTS page

[PMID:11463333-14] 14.0 ^14.1 Evans, PC et al. (2001) Isolation and characterization of two novel A20-like proteins. Biochem. J. 357 617-23 PubMed GONUTS page

[PMID:23827681-15] 15.0 ^15.1 ^15.2 Mevissen, TE et al. (2013) OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154 169-84 PubMed GONUTS page

[PMID:15258597-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Wertz, IE et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430 694-9 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14748687-18] Evans, PC et al. (2004) Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem. J. 378 727-34 PubMed GONUTS page

[PMID:28094437-19] Lee, JY et al. (2017) The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein. FEBS Lett. 591 479-490 PubMed GONUTS page

[PMID:30561431-20] Van Quickelberghe, E et al. (2018) A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Sci Data 5 180289 PubMed GONUTS page

[PMID:25416956-21] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

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