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HUMAN:TMPS4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TMPRSS4 (synonyms: TMPRSS3) | |
| Protein Name(s) | Transmembrane protease serine 4
Channel-activating protease 2 CAPH2 Membrane-type serine protease 2 MT-SP2 | |
| External Links | ||
| UniProt | Q9NRS4 | |
| EMBL | AF179224 AF216312 AK172766 AK303173 AY358530 EF445038 AP000665 AP002800 BC004855 BC011703 | |
| CCDS | CCDS31684.1 CCDS44743.1 CCDS53716.1 CCDS53717.1 | |
| RefSeq | NP_001077416.1 NP_001167023.1 NP_063947.1 | |
| UniGene | Hs.161985 | |
| ProteinModelPortal | Q9NRS4 | |
| SMR | Q9NRS4 | |
| STRING | 9606.ENSP00000339836 | |
| BindingDB | Q9NRS4 | |
| ChEMBL | CHEMBL2331048 | |
| MEROPS | S01.034 | |
| DMDM | 317373304 | |
| MaxQB | Q9NRS4 | |
| PaxDb | Q9NRS4 | |
| PRIDE | Q9NRS4 | |
| DNASU | 56649 | |
| Ensembl | ENST00000437212 ENST00000522824 ENST00000523251 ENST00000534111 ENST00000618855 | |
| GeneID | 56649 | |
| KEGG | hsa:56649 | |
| UCSC | uc010rxo.2 uc010rxr.2 uc021qre.1 | |
| CTD | 56649 | |
| GeneCards | GC11P117949 | |
| HGNC | HGNC:11878 | |
| HPA | HPA006238 | |
| MIM | 606565 | |
| neXtProt | NX_Q9NRS4 | |
| Orphanet | 363969 | |
| PharmGKB | PA36579 | |
| eggNOG | COG5640 | |
| GeneTree | ENSGT00760000118962 | |
| HOGENOM | HOG000251822 | |
| HOVERGEN | HBG013304 | |
| InParanoid | Q9NRS4 | |
| KO | K09635 | |
| OMA | QVSIQYN | |
| OrthoDB | EOG75B84T | |
| PhylomeDB | Q9NRS4 | |
| TreeFam | TF351678 | |
| ChiTaRS | TMPRSS4 | |
| GenomeRNAi | 56649 | |
| NextBio | 35500107 | |
| PRO | PR:Q9NRS4 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NRS4 | |
| CleanEx | HS_TMPRSS3 HS_TMPRSS4 | |
| ExpressionAtlas | Q9NRS4 | |
| Genevestigator | Q9NRS4 | |
| GO | GO:0016021 GO:0005044 GO:0004252 GO:0006508 | |
| Gene3D | 3.10.250.10 4.10.400.10 | |
| InterPro | IPR002172 IPR001254 IPR018114 IPR001314 IPR001190 IPR017448 IPR009003 | |
| Pfam | PF00089 | |
| PRINTS | PR00722 | |
| SMART | SM00192 SM00202 SM00020 | |
| SUPFAM | SSF50494 SSF56487 SSF57424 | |
| PROSITE | PS50287 PS50240 PS00134 PS00135 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045967 |
negative regulation of growth rate |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016192 |
vesicle-mediated transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005044 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCA5 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009611 |
response to wounding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCA5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005044 |
scavenger receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wallrapp, C et al. (2000) A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. Cancer Res. 60 2602-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Valero-Jiménez, A et al. (2018) Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury. PLoS ONE 13 e0192963 PubMed GONUTS page
