GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:TIGAR
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TIGAR (synonyms: C12orf5) | |
| Protein Name(s) | Fructose-2,6-bisphosphatase TIGAR
TP53-induced glycolysis and apoptosis regulator | |
| External Links | ||
| UniProt | Q9NQ88 | |
| EMBL | AJ272206 AY425618 AK313226 CH471116 BC012340 | |
| CCDS | CCDS8525.1 | |
| RefSeq | NP_065108.1 | |
| UniGene | Hs.504545 | |
| PDB | 3DCY | |
| PDBsum | 3DCY | |
| ProteinModelPortal | Q9NQ88 | |
| SMR | Q9NQ88 | |
| BioGrid | 121369 | |
| DIP | DIP-60093N | |
| IntAct | Q9NQ88 | |
| MINT | MINT-5003605 | |
| STRING | 9606.ENSP00000179259 | |
| DEPOD | Q9NQ88 | |
| PhosphoSite | Q9NQ88 | |
| DMDM | 74734311 | |
| MaxQB | Q9NQ88 | |
| PaxDb | Q9NQ88 | |
| PRIDE | Q9NQ88 | |
| DNASU | 57103 | |
| Ensembl | ENST00000179259 | |
| GeneID | 57103 | |
| KEGG | hsa:57103 | |
| UCSC | uc001qmp.3 | |
| CTD | 57103 | |
| GeneCards | GC12P004430 | |
| HGNC | HGNC:1185 | |
| HPA | CAB034010 | |
| MIM | 610775 | |
| neXtProt | NX_Q9NQ88 | |
| PharmGKB | PA25506 | |
| eggNOG | COG0406 | |
| GeneTree | ENSGT00390000013224 | |
| HOGENOM | HOG000060277 | |
| HOVERGEN | HBG108569 | |
| InParanoid | Q9NQ88 | |
| KO | K14634 | |
| OMA | ECPVFTP | |
| OrthoDB | EOG7CVPZ7 | |
| PhylomeDB | Q9NQ88 | |
| TreeFam | TF329053 | |
| ChiTaRS | C12orf5 | |
| EvolutionaryTrace | Q9NQ88 | |
| GeneWiki | C12orf5 | |
| GenomeRNAi | 57103 | |
| NextBio | 62937 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NQ88 | |
| CleanEx | HS_C12orf5 | |
| Genevestigator | Q9NQ88 | |
| GO | GO:0005622 GO:0004331 GO:0060576 GO:1901525 GO:2000378 GO:0010666 GO:0010332 GO:0009410 | |
| Gene3D | 3.40.50.1240 | |
| InterPro | IPR013078 IPR029033 IPR001345 | |
| Pfam | PF00300 | |
| SMART | SM00855 | |
| SUPFAM | SSF53254 | |
| PROSITE | PS00175 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0070585 |
protein localization to mitochondrion |
ECO:0000314 |
P |
Figure 1 shows Relocalization of TIGAR to mitochondria during hypoxia |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903301 |
positive regulation of hexokinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043069 |
negative regulation of programmed cell death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902153 |
regulation of response to DNA damage checkpoint signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043456 |
regulation of pentose-phosphate shunt |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045739 |
positive regulation of DNA repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071279 |
cellular response to cobalt ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004083 |
bisphosphoglycerate 2-phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004331 |
fructose-2,6-bisphosphate 2-phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030388 |
fructose 1,6-bisphosphate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006003 |
fructose 2,6-bisphosphate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002931 |
response to ischemia |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005622 |
intracellular |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004331 |
fructose-2,6-bisphosphate 2-phosphatase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004331 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004331 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004331 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004331 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904024 |
negative regulation of glucose catabolic process to lactate via pyruvate |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901525 |
negative regulation of mitophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060576 |
intestinal epithelial cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045820 |
negative regulation of glycolytic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010666 |
positive regulation of cardiac muscle cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010332 |
response to gamma radiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009410 |
response to xenobiotic stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006003 |
fructose 2,6-bisphosphate metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004331 |
fructose-2,6-bisphosphate 2-phosphatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002931 |
response to ischemia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BZA9 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004331 |
fructose-2,6-bisphosphate 2-phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5628905 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Cheung, EC et al. (2012) Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc. Natl. Acad. Sci. U.S.A. 109 20491-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Yu, HP et al. (2015) TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway. Sci Rep 5 9853 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Li, H & Jogl, G (2009) Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J. Biol. Chem. 284 1748-54 PubMed GONUTS page
- ↑ Bensaad, K et al. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126 107-20 PubMed GONUTS page
c
f
i
n
- GO:0045820 ! negative regulation of glycolytic process
- GO:0043069 ! negative regulation of programmed cell death
- GO:1901525 ! negative regulation of mitophagy
- GO:1904024 ! negative regulation of glucose catabolic process to lactate via pyruvate
- GO:2000378 ! negative regulation of reactive oxygen species metabolic process
- GO:0005634 ! nucleus
o
p
r
