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HUMAN:TFAM

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TFAM (synonyms: TCF6, TCF6L2)
Protein Name(s) Transcription factor A, mitochondrial

mtTFA Mitochondrial transcription factor 1 MtTF1 Transcription factor 6 TCF-6 Transcription factor 6-like 2

External Links
UniProt Q00059
EMBL M62810
EU279428
BT019658
BT019659
AK312558
AB451241
AB451366
AC023170
BC126366
X64269
CCDS CCDS59217.1
CCDS7253.1
PIR JC1496
RefSeq NP_001257711.1
NP_003192.1
UniGene Hs.594250
PDB 3FGH
3TMM
3TQ6
4NNU
4NOD
PDBsum 3FGH
3TMM
3TQ6
4NNU
4NOD
ProteinModelPortal Q00059
SMR Q00059
BioGrid 112877
IntAct Q00059
STRING 9606.ENSP00000420588
PhosphoSite Q00059
DMDM 417324
MaxQB Q00059
PaxDb Q00059
PRIDE Q00059
DNASU 7019
Ensembl ENST00000373895
ENST00000487519
GeneID 7019
KEGG hsa:7019
UCSC uc001jkf.4
CTD 7019
GeneCards GC10P060146
HGNC HGNC:11741
HPA HPA040648
MIM 600438
neXtProt NX_Q00059
PharmGKB PA36458
eggNOG NOG297801
GeneTree ENSGT00440000039001
HOGENOM HOG000139423
HOVERGEN HBG106674
InParanoid Q00059
KO K11830
OMA VYIQLAN
OrthoDB EOG7CG724
PhylomeDB Q00059
TreeFam TF318343
Reactome REACT_200608
REACT_367
ChiTaRS TFAM
EvolutionaryTrace Q00059
GeneWiki TFAM
GenomeRNAi 7019
NextBio 27419
PRO PR:Q00059
Proteomes UP000005640
Bgee Q00059
CleanEx HS_TFAM
ExpressionAtlas Q00059
Genevestigator Q00059
GO GO:0005759
GO:0042645
GO:0005739
GO:0005634
GO:0003682
GO:0008301
GO:0070363
GO:0044822
GO:0003700
GO:0006261
GO:0010467
GO:0033108
GO:0045893
GO:0006356
GO:0006390
GO:0006391
Gene3D 1.10.30.10
InterPro IPR009071
Pfam PF00505
PF09011
SMART SM00398
SUPFAM SSF47095
PROSITE PS50118

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005759

mitochondrial matrix

PMID:29445193[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:29445193[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:29445193[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0042645

mitochondrial nucleoid

PMID:18063578[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001018

mitochondrial promoter sequence-specific DNA binding

PMID:19304746[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20410300[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008301

DNA binding, bending

PMID:22037171[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006391

transcription initiation from mitochondrial promoter

PMID:20410300[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006390

mitochondrial transcription

PMID:22037171[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:22037171[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:18063578[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0042645

mitochondrial nucleoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40630
ensembl:ENSMUSP00000090086

C

Seeded From UniProt

complete

involved_in

GO:0033108

mitochondrial respiratory chain complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40630
ensembl:ENSMUSP00000090086

P

Seeded From UniProt

complete

involved_in

GO:0006390

mitochondrial transcription

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40630
ensembl:ENSMUSP00000090086

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40630
ensembl:ENSMUSP00000090086

C

Seeded From UniProt

complete

enables

GO:0001018

mitochondrial promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40630
ensembl:ENSMUSP00000090086

F

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91ZW1
ensembl:ENSRNOP00000000753

F

Seeded From UniProt

complete

involved_in

GO:0006390

mitochondrial transcription

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91ZW1
ensembl:ENSRNOP00000000753

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91ZW1
ensembl:ENSRNOP00000000753

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91ZW1
ensembl:ENSRNOP00000000753

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91ZW1
ensembl:ENSRNOP00000000753

F

Seeded From UniProt

complete

enables

GO:0001223

transcription coactivator binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91ZW1
ensembl:ENSRNOP00000000753

F

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

Reactome:R-HSA-1592230

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006391

transcription initiation from mitochondrial promoter

Reactome:R-HSA-163282

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1592246

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-163310
Reactome:R-HSA-163296

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0042645

mitochondrial nucleoid

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1135
UniProtKB-SubCell:SL-0269

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Celestini, V et al. (2018) Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis 9 231 PubMed GONUTS page
  2. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  3. ↑ 3.0 3.1 Bogenhagen, DF et al. (2008) The layered structure of human mitochondrial DNA nucleoids. J. Biol. Chem. 283 3665-75 PubMed GONUTS page
  4. ↑ Gangelhoff, TA et al. (2009) Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A. Nucleic Acids Res. 37 3153-64 PubMed GONUTS page
  5. ↑ 5.0 5.1 Litonin, D et al. (2010) Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. J. Biol. Chem. 285 18129-33 PubMed GONUTS page
  6. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  7. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Ngo, HB et al. (2011) The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nat. Struct. Mol. Biol. 18 1290-6 PubMed GONUTS page
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