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HUMAN:TET1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TET1 (synonyms: CXXC6, KIAA1676, LCX)
Protein Name(s) Methylcytosine dioxygenase TET1

CXXC-type zinc finger protein 6 Leukemia-associated protein with a CXXC domain Ten-eleven translocation 1 gene protein

External Links
UniProt Q8NFU7
EMBL AF430147
AL513534
AL713888
AL713888
AL513534
AB051463
AL713658
BC053905
CCDS CCDS7281.1
RefSeq NP_085128.2
UniGene Hs.258855
Hs.567594
Hs.598166
Hs.708977
ProteinModelPortal Q8NFU7
SMR Q8NFU7
BioGrid 123225
IntAct Q8NFU7
STRING 9606.ENSP00000362748
iPTMnet Q8NFU7
PhosphoSitePlus Q8NFU7
BioMuta TET1
DMDM 115502139
EPD Q8NFU7
PaxDb Q8NFU7
PeptideAtlas Q8NFU7
PRIDE Q8NFU7
DNASU 80312
Ensembl ENST00000373644
GeneID 80312
KEGG hsa:80312
UCSC uc001jok.5
CTD 80312
DisGeNET 80312
GeneCards TET1
HGNC HGNC:29484
HPA CAB014886
HPA019032
HPA057273
MIM 607790
neXtProt NX_Q8NFU7
OpenTargets ENSG00000138336
PharmGKB PA162405605
eggNOG ENOG410IE22
ENOG410XPWW
GeneTree ENSGT00510000046514
HOGENOM HOG000154549
InParanoid Q8NFU7
KO K13097
OMA NQKAHPL
OrthoDB EOG091G007O
PhylomeDB Q8NFU7
TreeFam TF324004
Reactome [www.reactome.org/content/detail/R-HSA-5221030 R-HSA-5221030]
ChiTaRS TET1
GeneWiki Tet_methylcytosine_dioxygenase_1
GenomeRNAi 80312
PRO PR:Q8NFU7
Proteomes UP000005640
Bgee ENSG00000138336
CleanEx HS_TET1
Genevisible Q8NFU7
GO GO:0005634
GO:0003677
GO:0005506
GO:0070579
GO:0008270
GO:0016569
GO:0080111
GO:0001826
GO:0090310
GO:0008284
GO:0031062
GO:0045944
GO:0006493
GO:0019827
GO:0006351
InterPro IPR024779
IPR002857
Pfam PF12851
PF02008
SMART SM01333
PROSITE PS51058

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:A1A5S2
UniProtKB:P13864
UniProtKB:P55200

F

Seeded From UniProt

complete

involved_in

GO:0031062

positive regulation of histone methylation

PMID:25284789[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070579

methylcytosine dioxygenase activity

PMID:25284789[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:25284789[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090310

negative regulation of methylation-dependent chromatin silencing

PMID:21496894[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

PMID:21496894[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070579

methylcytosine dioxygenase activity

PMID:21496894[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070579

methylcytosine dioxygenase activity

PMID:19372391[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3URK3

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:19372391[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019827

stem cell population maintenance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3URK3

P

Seeded From UniProt

complete

involved_in

GO:0006493

protein O-linked glycosylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3URK3

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19372391[3]

ECO:0000305

curator inference used in manual assertion

GO:0003677

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:19372391[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001826

inner cell mass cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3URK3

P

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1098693
MGI:MGI:2443298
MGI:MGI:2446229
PANTHER:PTN000599488
UniProtKB:Q6N021
UniProtKB:Q8NFU7

P

Seeded From UniProt

complete

involved_in

GO:0070989

oxidative demethylation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000599488
ZFIN:ZDB-GENE-090312-98

P

Seeded From UniProt

complete

enables

GO:0070579

methylcytosine dioxygenase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1098693
MGI:MGI:2443298
MGI:MGI:2446229
PANTHER:PTN000599488
UniProtKB:Q6N021
UniProtKB:Q8NFU7

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263392
MGI:MGI:1098693
MGI:MGI:2443298
PANTHER:PTN000599488
UniProtKB:O43151
UniProtKB:Q6N021

P

Seeded From UniProt

complete

involved_in

GO:0006211

5-methylcytosine catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000599488
UniProtKB:Q6N021

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263392
MGI:MGI:1098693
MGI:MGI:2446229
PANTHER:PTN000599488

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000599488
UniProtKB:Q8NFU7

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002857

F

Seeded From UniProt

complete

involved_in

GO:0006211

5-methylcytosine catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040175

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002857

F

Seeded From UniProt

complete

enables

GO:0070579

methylcytosine dioxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040175

F

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040175

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

enables

GO:0051213

dioxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0223

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Takai, H et al. (2014) 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Cell Rep 9 48-60 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Guo, JU et al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145 423-34 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Tahiliani, M et al. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324 930-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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