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HUMAN:TCTP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TPT1
Protein Name(s) Translationally-controlled tumor protein

TCTP Fortilin Histamine-releasing factor HRF p23

External Links
UniProt P13693
EMBL X16064
AJ400717
AY334563
AY117678
CR457036
AK312951
AL138963
CH471075
CH471075
BC003352
BC012431
BC022436
BC052333
CCDS CCDS66538.1
CCDS9397.1
PIR S06590
RefSeq NP_001273202.1
NP_003286.1
UniGene Hs.374596
Hs.717316
PDB 1YZ1
2HR9
3EBM
4Z9V
PDBsum 1YZ1
2HR9
3EBM
4Z9V
ProteinModelPortal P13693
SMR P13693
BioGrid 113030
DIP DIP-40097N
IntAct P13693
MINT MINT-2634453
STRING 9606.ENSP00000431872
Allergome 3816
iPTMnet P13693
PhosphoSite P13693
SwissPalm P13693
DMDM 136479
DOSAC-COBS-2DPAGE P13693
OGP P13693
REPRODUCTION-2DPAGE IPI00550900
SWISS-2DPAGE P13693
EPD P13693
MaxQB P13693
PaxDb P13693
PRIDE P13693
TopDownProteomics P13693-1
DNASU 7178
Ensembl ENST00000379055
ENST00000379056
ENST00000530705
GeneID 7178
KEGG hsa:7178
UCSC uc001uzy.3
CTD 7178
GeneCards TPT1
HGNC HGNC:12022
HPA CAB008364
HPA039437
MIM 600763
neXtProt NX_P13693
PharmGKB PA36701
eggNOG KOG1727
ENOG4111FVP
GeneTree ENSGT00390000006051
HOGENOM HOG000203361
HOVERGEN HBG002282
InParanoid P13693
OrthoDB EOG7SJD61
PhylomeDB P13693
TreeFam TF300238
SIGNOR P13693
ChiTaRS TPT1
EvolutionaryTrace P13693
GeneWiki TPT1
Translationally-controlled_tumor_protein
GenomeRNAi 7178
PRO PR:P13693
Proteomes UP000005640
Bgee P13693
CleanEx HS_TPT1
ExpressionAtlas P13693
Genevisible P13693
GO GO:0005737
GO:0070062
GO:0005615
GO:0005771
GO:0005634
GO:0005509
GO:0044822
GO:0006816
GO:0006874
GO:0043066
GO:1902230
GO:0042981
GO:0009615
Gene3D 2.170.150.10
InterPro IPR011057
IPR011323
IPR018103
IPR018105
PANTHER PTHR11991
Pfam PF00838
PRINTS PR01653
SUPFAM SSF51316
PROSITE PS01002
PS01003

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0000922

spindle pole

PMID:15162379[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000236)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005881

cytoplasmic microtubule

PMID:15162379[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000278)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:15162379[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:16548883[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006874

cellular calcium ion homeostasis

PMID:15958728[5]

ECO:0000305

curator inference used in manual assertion

GO:0005509

P

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

PMID:15958728[5]

ECO:0000305

curator inference used in manual assertion

GO:0005509

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15162379[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:15958728[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:15162379[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000241815
UniProtKB:P13693
UniProtKB:Q5BFN9
UniProtKB:Q8I3Z5

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000241815
UniProtKB:P13693
UniProtKB:Q8I3Z5

F

Seeded From UniProt

complete

involved_in

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

PMID:11598139[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005771

multivesicular body

PMID:15319436[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11598139[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:15319436[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:7542803[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:16130169[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16130169[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Arcuri, F et al. (2004) Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. Prostate 60 130-40 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. ↑ Leong, WF & Chow, VT (2006) Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell. Microbiol. 8 565-80 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Arcuri, F et al. (2005) The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. Biol. Reprod. 73 745-51 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Li, F et al. (2001) Characterization of fortilin, a novel antiapoptotic protein. J. Biol. Chem. 276 47542-9 PubMed GONUTS page
  8. ↑ 8.0 8.1 Amzallag, N et al. (2004) TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J. Biol. Chem. 279 46104-12 PubMed GONUTS page
  9. ↑ MacDonald, SM et al. (1995) Molecular identification of an IgE-dependent histamine-releasing factor. Science 269 688-90 PubMed GONUTS page
  10. ↑ 10.0 10.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
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