HUMAN:TBK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TBK1 (synonyms: NAK)
Protein Name(s)	Serine/threonine-protein kinase TBK1 NF-kappa-B-activating kinase T2K TANK-binding kinase 1
External Links
UniProt	Q9UHD2
EMBL	AF191838 AF174536 AK002192 AK291039 CH471054 BC034950
CCDS	CCDS8968.1
RefSeq	NP_037386.1 XP_005268866.1 XP_005268867.1
UniGene	Hs.505874
PDB	4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ
PDBsum	4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ
ProteinModelPortal	Q9UHD2
SMR	Q9UHD2
BioGrid	118878
DIP	DIP-27529N
IntAct	Q9UHD2
MINT	MINT-1131333
STRING	9606.ENSP00000329967
BindingDB	Q9UHD2
ChEMBL	CHEMBL5408
GuidetoPHARMACOLOGY	2237
PhosphoSite	Q9UHD2
BioMuta	TBK1
DMDM	74761953
MaxQB	Q9UHD2
PaxDb	Q9UHD2
PeptideAtlas	Q9UHD2
PRIDE	Q9UHD2
DNASU	29110
Ensembl	ENST00000331710
GeneID	29110
KEGG	hsa:29110
UCSC	uc001ssc.2
CTD	29110
GeneCards	GC12P064845
HGNC	HGNC:11584
HPA	HPA045797
MIM	177700 604834
neXtProt	NX_Q9UHD2
Orphanet	1930
PharmGKB	PA36348
eggNOG	COG0515
GeneTree	ENSGT00790000122961
HOGENOM	HOG000220867
HOVERGEN	HBG008494
InParanoid	Q9UHD2
KO	K05410
OMA	FRGRHKK
OrthoDB	EOG7Z95KH
PhylomeDB	Q9UHD2
TreeFam	TF324269
Reactome	REACT_118811 REACT_163734 REACT_163977 REACT_163993 REACT_24938 REACT_25026 REACT_25148 REACT_25271
SABIO-RK	Q9UHD2
SignaLink	Q9UHD2
GeneWiki	TANK-binding_kinase_1
GenomeRNAi	29110
NextBio	52179
PRO	PR:Q9UHD2
Proteomes	UP000005640
Bgee	Q9UHD2
CleanEx	HS_TBK1
ExpressionAtlas	Q9UHD2
Genevisible	Q9UHD2
GO	GO:0005737 GO:0005829 GO:0010008 GO:0005524 GO:0003676 GO:0051219 GO:0004672 GO:0004674 GO:0050830 GO:0051607 GO:0044565 GO:0007249 GO:0006954 GO:0045087 GO:0002756 GO:0010629 GO:0032480 GO:0043123 GO:0032727 GO:0045359 GO:0032728 GO:0033138 GO:0045944 GO:0032481 GO:0009615 GO:0034138 GO:0034142 GO:0002224 GO:0035666 GO:0032606 GO:0016032
InterPro	IPR011009 IPR000719 IPR017441
Pfam	PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0019903	protein phosphatase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WUN2	F	occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032479	regulation of type I interferon production	PMID:25636800^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:25636800^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:25636800^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:25636800^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:25636800^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27103069^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q8TEV9) part_of:(GO:0016239)	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:27103069^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:27103069^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q8TEV9) part_of:(GO:0016239)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:27103069^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q8TEV9) part_of:(GO:0016239)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:27103069^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27103069^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:25803835^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q14653)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:25803835^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q14653)	Seeded From UniProt	complete
involved_in	GO:1901214	regulation of neuron death	PMID:25803835^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10581243^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16127453^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:22412986^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:Q13568)	Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:16127453^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	PMID:16127453^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:14530355^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IUC6	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21813773^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024222 FB:FBgn0086657 MGI:MGI:1929658 PANTHER:PTN001491808 UniProtKB:O14920 UniProtKB:Q9UHD2	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024222 FB:FBgn0086657 MGI:MGI:1929658 PANTHER:PTN001491808 UniProtKB:O14920 UniProtKB:Q9UHD2	F		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904417	positive regulation of xenophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
involved_in	GO:0044565	dendritic cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	F		Seeded From UniProt	complete
involved_in	GO:0031323	regulation of cellular metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	F		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	F		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUN2 ensembl:ENSMUSP00000020316	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:10581243^[4] PMID:21042276^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21042276^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032606	type I interferon production	PMID:21042276^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:21042276^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21042276^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21042276^[11] Reactome:R-HSA-3249371 Reactome:R-HSA-2396007	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	Reactome:R-HSA-9008059	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Reactome:R-HSA-936964 Reactome:R-HSA-9013973	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-3270619 Reactome:R-HSA-1834941	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032480	negative regulation of type I interferon production	Reactome:R-HSA-936440	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032479	regulation of type I interferon production	Reactome:R-HSA-3134975	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-936941 Reactome:R-HSA-9013986 Reactome:R-HSA-9013979 Reactome:R-HSA-9013978 Reactome:R-HSA-166271 Reactome:R-HSA-166245	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-937337 Reactome:R-HSA-936941 Reactome:R-HSA-933538 Reactome:R-HSA-933527 Reactome:R-HSA-933525 Reactome:R-HSA-918232 Reactome:R-HSA-918229 Reactome:R-HSA-918225 Reactome:R-HSA-9013986 Reactome:R-HSA-9008684 Reactome:R-HSA-8948709 Reactome:R-HSA-8948703 Reactome:R-HSA-3249392 Reactome:R-HSA-3249390 Reactome:R-HSA-3249386 Reactome:R-HSA-3249378 Reactome:R-HSA-3249371 Reactome:R-HSA-2396007 Reactome:R-HSA-2396002 Reactome:R-HSA-1834939 Reactome:R-HSA-1606327	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	Reactome:R-HSA-933525 Reactome:R-HSA-918229	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:25636800^[1]	ECO:0000314			F		Figure 3E shows a higher ratio of pMAVS to MAVS when concentration of TBK1 is increased.	complete CACAO 10990
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:25636800^[1]	ECO:0000314			P		Figure 5F shows that TBK1 is required for activation of STING and IRF3 dimerization.	complete CACAO 11124
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
	GO:0023014	signal transduction by protein phosphorylation	PMID:25636800^[1]	ECO:0000314			P		Figure 3E shows a higher ratio of pMAVS to MAVS when concentration of TBK1 is increased, this further transduces the signal to IRF3	complete CACAO 11178
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sellier, C et al. (2016) Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. EMBO J. 35 1276-97 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Freischmidt, A et al. (2015) Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat. Neurosci. 18 631-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Pomerantz, JL & Baltimore, D (1999) NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 18 6694-704 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kawai, T et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6 981-8 PubMed GONUTS page
↑ Chang Foreman, HC et al. (2012) Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS ONE 7 e33098 PubMed GONUTS page
↑ Sato, S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171 4304-10 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ Liu, XY et al. (2011) IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J. Immunol. 187 2559-68 PubMed GONUTS page
↑ ^10.0 ^10.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Shen, RR & Hahn, WC (2011) Emerging roles for the non-canonical IKKs in cancer. Oncogene 30 631-41 PubMed GONUTS page

[PMID:25636800-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

[PMID:27103069-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sellier, C et al. (2016) Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. EMBO J. 35 1276-97 PubMed GONUTS page

[PMID:25803835-3] 3.0 ^3.1 ^3.2 Freischmidt, A et al. (2015) Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat. Neurosci. 18 631-6 PubMed GONUTS page

[PMID:10581243-4] 4.0 ^4.1 Pomerantz, JL & Baltimore, D (1999) NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 18 6694-704 PubMed GONUTS page

[PMID:16127453-5] 5.0 ^5.1 ^5.2 Kawai, T et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6 981-8 PubMed GONUTS page

[PMID:22412986-6] Chang Foreman, HC et al. (2012) Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS ONE 7 e33098 PubMed GONUTS page

[PMID:14530355-7] Sato, S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171 4304-10 PubMed GONUTS page

[PMID:12761501-8] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:21813773-9] Liu, XY et al. (2011) IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J. Immunol. 187 2559-68 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21042276-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Shen, RR & Hahn, WC (2011) Emerging roles for the non-canonical IKKs in cancer. Oncogene 30 631-41 PubMed GONUTS page

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HUMAN:TBK1

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References

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