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HUMAN:SYNE2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SYNE2 (synonyms: KIAA1011, NUA) | |
| Protein Name(s) | Nesprin-2
Nuclear envelope spectrin repeat protein 2 Nucleus and actin connecting element protein Protein NUANCE Synaptic nuclear envelope protein 2 Syne-2 | |
| External Links | ||
| UniProt | Q8WXH0 | |
| EMBL | AF435010 AF435011 AY061757 AY061758 AY061759 AY184204 AF495911 AL117404 AL162832 AL355094 AL359235 BC042134 BC071873 AK074055 AK090430 AK095241 AB023228 AL080133 | |
| CCDS | CCDS41963.1 CCDS45124.1 CCDS45125.1 CCDS9761.2 | |
| PIR | T12520 T17215 | |
| RefSeq | NP_055995.4 NP_878914.1 NP_878917.1 NP_878918.2 | |
| UniGene | Hs.745014 | |
| PDB | 4DXS 4FI9 | |
| PDBsum | 4DXS 4FI9 | |
| ProteinModelPortal | Q8WXH0 | |
| SMR | Q8WXH0 | |
| BioGrid | 116830 | |
| DIP | DIP-53409N | |
| IntAct | Q8WXH0 | |
| MINT | MINT-4136337 | |
| PhosphoSite | Q8WXH0 | |
| DMDM | 116242809 | |
| MaxQB | Q8WXH0 | |
| PaxDb | Q8WXH0 | |
| PRIDE | Q8WXH0 | |
| Ensembl | ENST00000341472 ENST00000344113 ENST00000358025 ENST00000394768 ENST00000441438 ENST00000458046 ENST00000555002 ENST00000555022 | |
| GeneID | 23224 | |
| KEGG | hsa:23224 | |
| UCSC | uc001xgl.3 uc001xgm.3 uc001xgn.3 uc001xgs.3 uc001xgt.3 uc010aqa.3 | |
| CTD | 23224 | |
| GeneCards | GC14P064319 | |
| HGNC | HGNC:17084 | |
| HPA | HPA003435 HPA050204 | |
| MIM | 608442 612999 | |
| neXtProt | NX_Q8WXH0 | |
| Orphanet | 98853 | |
| PharmGKB | PA128394613 | |
| eggNOG | COG5069 | |
| GeneTree | ENSGT00760000118813 | |
| InParanoid | Q8WXH0 | |
| OMA | LMIPFQQ | |
| OrthoDB | EOG72JWF7 | |
| PhylomeDB | Q8WXH0 | |
| TreeFam | TF329280 | |
| Reactome | REACT_75792 | |
| ChiTaRS | SYNE2 | |
| GeneWiki | SYNE2 | |
| GenomeRNAi | 23224 | |
| NextBio | 44823 | |
| PRO | PR:Q8WXH0 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WXH0 | |
| ExpressionAtlas | Q8WXH0 | |
| Genevestigator | Q8WXH0 | |
| GO | GO:0016235 GO:0005737 GO:0070062 GO:0031527 GO:0005925 GO:0016021 GO:0045111 GO:0031258 GO:0005739 GO:0005635 GO:0031981 GO:0031965 GO:0005640 GO:0005654 GO:0005634 GO:0016529 GO:0033017 GO:0034993 GO:0030018 GO:0003779 GO:0051642 GO:0090286 GO:0007163 GO:0010761 GO:0006998 GO:0007097 GO:0031022 GO:0030335 GO:0034504 | |
| Gene3D | 1.10.418.10 | |
| InterPro | IPR001589 IPR001715 IPR012315 IPR018159 IPR002017 IPR030266 | |
| PANTHER | PTHR11915:SF264 | |
| Pfam | PF00307 PF10541 PF00435 | |
| SMART | SM00033 SM00150 | |
| SUPFAM | SSF47576 | |
| PROSITE | PS00019 PS00020 PS50021 PS51049 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 5 shows that NUANCE localizes to the nucleus through immunolabeling. |
complete | |||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 5 shows that NUANCE can localize to the cytoplasm through immunolabeling. |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000047) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090286 |
cytoskeletal anchoring at nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051642 |
centrosome localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034993 |
meiotic nuclear membrane microtubule tethering complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031981 |
nuclear lumen |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031527 |
filopodium membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031258 |
lamellipodium membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031022 |
nuclear migration along microfilament |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030018 |
Z disc |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016529 |
sarcoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007097 |
nuclear migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010457 |
centriole-centriole cohesion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001025955 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001025955 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045111 |
intermediate filament cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016235 |
aggresome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902017 |
regulation of cilium assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051642 |
centrosome localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031022 |
nuclear migration along microfilament |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030018 |
Z disc |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030016 |
myofibril |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021817 |
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003779 |
actin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6ZWQ0 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034993 |
meiotic nuclear membrane microtubule tethering complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051015 |
actin filament binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090286 |
cytoskeletal anchoring at nuclear membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016529 |
sarcoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005640 |
nuclear outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030018 |
Z disc |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033017 |
sarcoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zhen, YY et al. (2002) NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. J. Cell. Sci. 115 3207-22 PubMed GONUTS page
- ↑ Kang, D et al. (2008) Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. J. Proteome Res. 7 3475-80 PubMed GONUTS page
- ↑ 3.0 3.1 Stewart-Hutchinson, PJ et al. (2008) Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp. Cell Res. 314 1892-905 PubMed GONUTS page
- ↑ 4.0 4.1 Luxton, GW et al. (2010) Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science 329 956-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Zhang, Q et al. (2005) Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. J. Cell. Sci. 118 673-87 PubMed GONUTS page
- ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
m
n
- GO:0005635 ! nuclear envelope
- GO:0031981 ! nuclear lumen
- GO:0031965 ! nuclear membrane
- GO:0007097 ! nuclear migration
- GO:0031022 ! nuclear migration along microfilament
- GO:0005640 ! nuclear outer membrane
- GO:0021817 ! nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
