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HUMAN:SYNE1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SYNE1 (synonyms: C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1)
Protein Name(s) Nesprin-1

Enaptin Myocyte nuclear envelope protein 1 Myne-1 Nuclear envelope spectrin repeat protein 1 Synaptic nuclear envelope protein 1 Syne-1

External Links
UniProt Q8NF91
EMBL AY061755
AY061756
AF495910
AF535142
AY184203
AY184206
AL049548
AL136079
AL589963
AL591507
AL450401
AL078582
AL138832
AL450401
AL078582
AL138832
AL357081
AL357081
AL078582
AL138832
AL450401
AL078582
AL138832
AL450401
AL078582
AL138832
AL357081
AL450401
AL138832
AL078582
AL450401
AL138832
AL078582
AL357081
AL450401
AY135172
AY183142
AK056122
AK094094
AB051543
AL713682
AB033088
AB018339
AF444779
AF043290
CCDS CCDS5235.1
CCDS5236.2
RefSeq NP_149062.1
NP_892006.3
XP_006715482.1
UniGene Hs.12967
PDB 4DXR
PDBsum 4DXR
ProteinModelPortal Q8NF91
BioGrid 116928
IntAct Q8NF91
MINT MINT-6489007
PhosphoSite Q8NF91
DMDM 425906075
MaxQB Q8NF91
PaxDb Q8NF91
PRIDE Q8NF91
Ensembl ENST00000367253
ENST00000367255
ENST00000413186
ENST00000423061
GeneID 23345
KEGG hsa:23345
UCSC uc003qos.4
uc003qot.4
uc003qou.4
uc003qow.3
CTD 23345
GeneCards GC06M152442
GeneReviews SYNE1
HGNC HGNC:17089
HPA HPA019113
MIM 608441
610743
612998
neXtProt NX_Q8NF91
Orphanet 98853
88644
319332
PharmGKB PA134975331
eggNOG COG5069
GeneTree ENSGT00760000118813
HOVERGEN HBG066187
InParanoid Q8NF91
OMA MKWESLH
OrthoDB EOG72JWF7
TreeFam TF329280
Reactome REACT_75792
ChiTaRS SYNE1
GeneWiki Enaptin
GenomeRNAi 23345
NextBio 45305
PRO PR:Q8NF91
Proteomes UP000005640
Bgee Q8NF91
ExpressionAtlas Q8NF91
Genevestigator Q8NF91
GO GO:0005737
GO:0005856
GO:0005794
GO:0016021
GO:0005635
GO:0031965
GO:0005640
GO:0005634
GO:0045211
GO:0030017
GO:0034993
GO:0003779
GO:0051015
GO:0005521
GO:0044822
GO:0042803
GO:0090286
GO:0040023
GO:0007030
GO:0042692
GO:0090292
GO:0006997
Gene3D 1.10.418.10
InterPro IPR001589
IPR001715
IPR012315
IPR018159
IPR002017
IPR030265
PANTHER PTHR11915:SF267
Pfam PF00307
PF10541
PF00435
SMART SM00033
SM00150
SUPFAM SSF47576
PROSITE PS00019
PS00020
PS50021
PS51049

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0019899

enzyme binding

PMID:24862572[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UKV8

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:24862572[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P26196

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:24862572[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NPI6

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:24862572[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0002620)
  • part_of:(UBERON:0002067)

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:24862572[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0002620)
  • part_of:(UBERON:0002067)|part_of:(CL:0000359)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

involved_in

GO:0090292

nuclear matrix anchoring at nuclear membrane

PMID:11801724[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090286

cytoskeletal anchoring at nuclear membrane

PMID:18396275[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6ZWR6

F

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

PMID:10878022[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6ZWR6

F

Seeded From UniProt

complete

involved_in

GO:0042692

muscle cell differentiation

PMID:11792814[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034993

meiotic nuclear membrane microtubule tethering complex

PMID:18396275[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:11792814[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007030

Golgi organization

PMID:12808039[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006997

nucleus organization

PMID:11792814[8]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:12808039[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11792814[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:11792814[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005521

lamin binding

PMID:11801724[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02545

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:12408964[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

PMID:12408964[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030265

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012315

C

Seeded From UniProt

complete

part_of

GO:0034993

meiotic nuclear membrane microtubule tethering complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030265

C

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030265

F

Seeded From UniProt

complete

involved_in

GO:0090286

cytoskeletal anchoring at nuclear membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030265

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:12163176[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8NF91-11

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

part_of

GO:0005640

nuclear outer membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0183

C

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0313

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Rajgor, D et al. (2014) Mammalian microtubule P-body dynamics are mediated by nesprin-1. J. Cell Biol. 205 457-75 PubMed GONUTS page
  2. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  3. 3.0 3.1 Mislow, JM et al. (2002) Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. J. Cell. Sci. 115 61-70 PubMed GONUTS page
  4. 4.0 4.1 Stewart-Hutchinson, PJ et al. (2008) Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp. Cell Res. 314 1892-905 PubMed GONUTS page
  5. Apel, ED et al. (2000) Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J. Biol. Chem. 275 31986-95 PubMed GONUTS page
  6. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  7. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Zhang, Q et al. (2001) Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J. Cell. Sci. 114 4485-98 PubMed GONUTS page
  9. 9.0 9.1 Gough, LL et al. (2003) Golgi localization of Syne-1. Mol. Biol. Cell 14 2410-24 PubMed GONUTS page
  10. 10.0 10.1 Zhang, Q et al. (2002) The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics 80 473-81 PubMed GONUTS page
  11. Mislow, JM et al. (2002) Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 525 135-40 PubMed GONUTS page