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HUMAN:SYNE1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | SYNE1 (synonyms: C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1) | |
Protein Name(s) | Nesprin-1
Enaptin Myocyte nuclear envelope protein 1 Myne-1 Nuclear envelope spectrin repeat protein 1 Synaptic nuclear envelope protein 1 Syne-1 | |
External Links | ||
UniProt | Q8NF91 | |
EMBL | AY061755 AY061756 AF495910 AF535142 AY184203 AY184206 AL049548 AL136079 AL589963 AL591507 AL450401 AL078582 AL138832 AL450401 AL078582 AL138832 AL357081 AL357081 AL078582 AL138832 AL450401 AL078582 AL138832 AL450401 AL078582 AL138832 AL357081 AL450401 AL138832 AL078582 AL450401 AL138832 AL078582 AL357081 AL450401 AY135172 AY183142 AK056122 AK094094 AB051543 AL713682 AB033088 AB018339 AF444779 AF043290 | |
CCDS | CCDS5235.1 CCDS5236.2 | |
RefSeq | NP_149062.1 NP_892006.3 XP_006715482.1 | |
UniGene | Hs.12967 | |
PDB | 4DXR | |
PDBsum | 4DXR | |
ProteinModelPortal | Q8NF91 | |
BioGrid | 116928 | |
IntAct | Q8NF91 | |
MINT | MINT-6489007 | |
PhosphoSite | Q8NF91 | |
DMDM | 425906075 | |
MaxQB | Q8NF91 | |
PaxDb | Q8NF91 | |
PRIDE | Q8NF91 | |
Ensembl | ENST00000367253 ENST00000367255 ENST00000413186 ENST00000423061 | |
GeneID | 23345 | |
KEGG | hsa:23345 | |
UCSC | uc003qos.4 uc003qot.4 uc003qou.4 uc003qow.3 | |
CTD | 23345 | |
GeneCards | GC06M152442 | |
GeneReviews | SYNE1 | |
HGNC | HGNC:17089 | |
HPA | HPA019113 | |
MIM | 608441 610743 612998 | |
neXtProt | NX_Q8NF91 | |
Orphanet | 98853 88644 319332 | |
PharmGKB | PA134975331 | |
eggNOG | COG5069 | |
GeneTree | ENSGT00760000118813 | |
HOVERGEN | HBG066187 | |
InParanoid | Q8NF91 | |
OMA | MKWESLH | |
OrthoDB | EOG72JWF7 | |
TreeFam | TF329280 | |
Reactome | REACT_75792 | |
ChiTaRS | SYNE1 | |
GeneWiki | Enaptin | |
GenomeRNAi | 23345 | |
NextBio | 45305 | |
PRO | PR:Q8NF91 | |
Proteomes | UP000005640 | |
Bgee | Q8NF91 | |
ExpressionAtlas | Q8NF91 | |
Genevestigator | Q8NF91 | |
GO | GO:0005737 GO:0005856 GO:0005794 GO:0016021 GO:0005635 GO:0031965 GO:0005640 GO:0005634 GO:0045211 GO:0030017 GO:0034993 GO:0003779 GO:0051015 GO:0005521 GO:0044822 GO:0042803 GO:0090286 GO:0040023 GO:0007030 GO:0042692 GO:0090292 GO:0006997 | |
Gene3D | 1.10.418.10 | |
InterPro | IPR001589 IPR001715 IPR012315 IPR018159 IPR002017 IPR030265 | |
PANTHER | PTHR11915:SF267 | |
Pfam | PF00307 PF10541 PF00435 | |
SMART | SM00033 SM00150 | |
SUPFAM | SSF47576 | |
PROSITE | PS00019 PS00020 PS50021 PS51049 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000932 |
P-body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000019) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090292 |
nuclear matrix anchoring at nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090286 |
cytoskeletal anchoring at nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051015 |
actin filament binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042692 |
muscle cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0034993 |
meiotic nuclear membrane microtubule tethering complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006997 |
nucleus organization |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005521 |
lamin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003779 |
actin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0030017 |
sarcomere |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0034993 |
meiotic nuclear membrane microtubule tethering complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0051015 |
actin filament binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090286 |
cytoskeletal anchoring at nuclear membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005640 |
nuclear outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030017 |
sarcomere |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Rajgor, D et al. (2014) Mammalian microtubule P-body dynamics are mediated by nesprin-1. J. Cell Biol. 205 457-75 PubMed GONUTS page
- ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
- ↑ 3.0 3.1 Mislow, JM et al. (2002) Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. J. Cell. Sci. 115 61-70 PubMed GONUTS page
- ↑ 4.0 4.1 Stewart-Hutchinson, PJ et al. (2008) Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp. Cell Res. 314 1892-905 PubMed GONUTS page
- ↑ Apel, ED et al. (2000) Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J. Biol. Chem. 275 31986-95 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Zhang, Q et al. (2001) Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J. Cell. Sci. 114 4485-98 PubMed GONUTS page
- ↑ 9.0 9.1 Gough, LL et al. (2003) Golgi localization of Syne-1. Mol. Biol. Cell 14 2410-24 PubMed GONUTS page
- ↑ 10.0 10.1 Zhang, Q et al. (2002) The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics 80 473-81 PubMed GONUTS page
- ↑ Mislow, JM et al. (2002) Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 525 135-40 PubMed GONUTS page
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