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HUMAN:STX8

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) STX8
Protein Name(s) Syntaxin-8
External Links
UniProt Q9UNK0
EMBL AF115323
AF062077
AF036715
BT007319
CH471108
BC009713
CCDS CCDS32565.1
RefSeq NP_004844.1
UniGene Hs.431109
ProteinModelPortal Q9UNK0
SMR Q9UNK0
BioGrid 114867
DIP DIP-47274N
IntAct Q9UNK0
MINT MINT-1396123
STRING 9606.ENSP00000305255
PhosphoSite Q9UNK0
DMDM 9297054
MaxQB Q9UNK0
PaxDb Q9UNK0
PRIDE Q9UNK0
DNASU 9482
Ensembl ENST00000306357
GeneID 9482
KEGG hsa:9482
UCSC uc002glx.3
CTD 9482
GeneCards GC17M009153
HGNC HGNC:11443
HPA HPA001540
MIM 604203
neXtProt NX_Q9UNK0
PharmGKB PA36240
eggNOG NOG259218
GeneTree ENSGT00390000007779
HOGENOM HOG000031515
HOVERGEN HBG007572
InParanoid Q9UNK0
KO K08501
OMA NQYERNG
PhylomeDB Q9UNK0
TreeFam TF323262
ChiTaRS STX8
GeneWiki STX8
GenomeRNAi 9482
NextBio 35540
PRO PR:Q9UNK0
Proteomes UP000005640
Bgee Q9UNK0
CleanEx HS_STX8
ExpressionAtlas Q9UNK0
Genevestigator Q9UNK0
GO GO:0005769
GO:0005783
GO:0005768
GO:0005887
GO:0005770
GO:0031902
GO:0005765
GO:0048471
GO:0055037
GO:0031201
GO:0005802
GO:0031982
GO:0019869
GO:0005484
GO:0019905
GO:0045022
GO:0008333
GO:0006886
GO:1903076
GO:0006810
GO:0006906
InterPro IPR000727
Pfam PF05739
SMART SM00397
PROSITE PS50192

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0055037

recycling endosome

PMID:23142642[1]

ECO:0000314

C

Confirmed with a MYTH screen of human adult brain cDNA library, Table 1 shows the function of the protien STX8 in endosome trafficking.

complete
CACAO 5762

part_of

GO:0055037

recycling endosome

PMID:18570918[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

PMID:18570918[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:18570918[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903076

regulation of protein localization to plasma membrane

PMID:18570918[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019869

chloride channel inhibitor activity

PMID:18570918[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045022

early endosome to late endosome transport

PMID:10564279[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019905

syntaxin binding

PMID:10564279[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O15400

F

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:10564279[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:10564279[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:10564279[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:10564279[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048278

vesicle docking

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461349
SGD:S000005632

P

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
FB:FBgn0035540
MGI:MGI:103077
MGI:MGI:893577
PANTHER:PTN000461349
RGD:61917
RGD:619747
RGD:621005
RGD:621019
RGD:68426
SGD:S000002876
SGD:S000003180
SGD:S000004016
SGD:S000005378
SGD:S000005632
SGD:S000006153
UniProtKB:O14662
UniProtKB:O43752
UniProtKB:P56962
UniProtKB:Q12846
UniProtKB:Q16623
UniProtKB:Q86Y82
dictyBase:DDB_G0275429

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031106
PANTHER:PTN000461349
RGD:61915
SGD:S000004016

C

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461349
TAIR:locus:2025620

C

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
MGI:MGI:103077
PANTHER:PTN000461349
RGD:61917
RGD:619747
SGD:S000002876
SGD:S000003180
SGD:S000004016
SGD:S000005378
SGD:S000005632
SGD:S000006153
UniProtKB:O43752
dictyBase:DDB_G0275429
dictyBase:DDB_G0287733

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461349
UniProtKB:Q946Y7

P

Seeded From UniProt

complete

enables

GO:0005484

SNAP receptor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011708
FB:FBgn0013343
FB:FBgn0031106
FB:FBgn0035540
PANTHER:PTN000461349
RGD:619747
RGD:621005
RGD:621019
SGD:S000000012
SGD:S000002876
SGD:S000003180
SGD:S000004016
SGD:S000004795
SGD:S000005378
SGD:S000005562
SGD:S000005632
SGD:S000006153
TAIR:locus:2148960
UniProtKB:O14662
UniProtKB:P56962
UniProtKB:Q13190

F

Seeded From UniProt

complete

enables

GO:0000149

SNARE binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
FB:FBgn0035540
MGI:MGI:109355
MGI:MGI:893577
PANTHER:PTN000461349
RGD:2558
RGD:619747
RGD:621019
RGD:69430
RGD:708499
UniProtKB:O15400
UniProtKB:P56962

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0045022

C

Seeded From UniProt

complete

involved_in

GO:0071346

cellular response to interferon-gamma

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88983
ensembl:ENSMUSP00000021285

P

Seeded From UniProt

complete

part_of

GO:0045335

phagocytic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88983
ensembl:ENSMUSP00000021285

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88983
ensembl:ENSMUSP00000021285

F

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2Q7
ensembl:ENSRNOP00000005204

C

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2Q7
ensembl:ENSRNOP00000005204

C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2Q7
ensembl:ENSRNOP00000005204

P

Seeded From UniProt

complete

involved_in

GO:0008333

endosome to lysosome transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2Q7
ensembl:ENSRNOP00000005204

P

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2Q7
ensembl:ENSRNOP00000005204

P

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2Q7
ensembl:ENSRNOP00000005204

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:10198254[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:9852078[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Passantino, R et al. (2013) Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Biochim. Biophys. Acta 1833 529-40 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Bilan, F et al. (2008) Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. Exp. Cell Res. 314 2199-211 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Prekeris, R et al. (1999) Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Mol. Biol. Cell 10 3891-908 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Thoreau, V et al. (1999) Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). Biochem. Biophys. Res. Commun. 257 577-83 PubMed GONUTS page
  6. ↑ Steegmaier, M et al. (1998) Three novel proteins of the syntaxin/SNAP-25 family. J. Biol. Chem. 273 34171-9 PubMed GONUTS page
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