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HUMAN:STN1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) OBFC1 (synonyms: STN1)
Protein Name(s) CST complex subunit STN1

Oligonucleotide/oligosaccharide-binding fold-containing protein 1 Suppressor of cdc thirteen homolog

External Links
UniProt Q9H668
EMBL AK026212
AL133355
CH471066
CH471066
BC017400
CCDS CCDS7552.1
RefSeq NP_079204.2
XP_006718039.1
UniGene Hs.62314
PDB 4JOI
4JQF
PDBsum 4JOI
4JQF
ProteinModelPortal Q9H668
SMR Q9H668
BioGrid 123054
DIP DIP-59914N
IntAct Q9H668
MINT MINT-1482105
STRING 9606.ENSP00000224950
PhosphoSite Q9H668
BioMuta OBFC1
DMDM 62900737
MaxQB Q9H668
PaxDb Q9H668
PRIDE Q9H668
DNASU 79991
Ensembl ENST00000224950
ENST00000369764
GeneID 79991
KEGG hsa:79991
UCSC uc001kxl.3
CTD 79991
GeneCards GC10M105632
HGNC HGNC:26200
HPA HPA037924
HPA037925
MIM 613128
neXtProt NX_Q9H668
Orphanet 2032
PharmGKB PA134987118
eggNOG NOG256914
GeneTree ENSGT00390000000909
HOGENOM HOG000088638
HOVERGEN HBG053364
InParanoid Q9H668
OMA QTFYQQE
OrthoDB EOG76QFHT
PhylomeDB Q9H668
TreeFam TF328623
ChiTaRS OBFC1
GenomeRNAi 79991
NextBio 70050
PRO PR:Q9H668
Proteomes UP000005640
Bgee Q9H668
CleanEx HS_OBFC1
Genevisible Q9H668
GO GO:0045111
GO:0043231
GO:0000784
GO:0005730
GO:0005654
GO:0005634
GO:0070188
GO:0003697
GO:0043047
GO:0045740
GO:0000723
GO:0010833
Gene3D 2.40.50.140
InterPro IPR014647
IPR015253
IPR012340
IPR004365
Pfam PF09170
PF01336
PIRSF PIRSF036950
SUPFAM SSF50249

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:1990879

CST complex

PMID:19854130[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

PMID:19854130[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032211

negative regulation of telomere maintenance via telomerase

PMID:22763445[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:19135898[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990879

CST complex

PMID:22763445[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045740

positive regulation of DNA replication

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K2X3

P

Seeded From UniProt

complete

enables

GO:0043047

single-stranded telomeric DNA binding

PMID:19648609[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010833

telomere maintenance via telomere lengthening

PMID:19648609[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19854130[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K2X3

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K2X3

F

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:19648609[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:19854130[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

PMID:19854130[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990879

CST complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915581
PANTHER:PTN000383864
UniProtKB:Q9H668

C

Seeded From UniProt

complete

enables

GO:0043047

single-stranded telomeric DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000383864
UniProtKB:Q9H668

F

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915581
PANTHER:PTN000383864
UniProtKB:Q9H668

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915581
PANTHER:PTN001421418
PomBase:SPCC1753.01c
RGD:619714
SGD:S000005256
TAIR:locus:2007352
TAIR:locus:2061072
UniProtKB:P15927
UniProtKB:Q13156
UniProtKB:Q57ZN9
UniProtKB:Q6K9U2
UniProtKB:Q8LFJ8
UniProtKB:Q9H668

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915581
PANTHER:PTN001421418
RGD:619714
SGD:S000005256
UniProtKB:P15927
UniProtKB:Q59Z33
UniProtKB:Q9H668

F

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000383864
TAIR:locus:2007352
UniProtKB:Q9H668

P

Seeded From UniProt

complete

part_of

GO:0045111

intermediate filament cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990879

CST complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2X3
ensembl:ENSMUSP00000040944

C

Seeded From UniProt

complete

involved_in

GO:0045740

positive regulation of DNA replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2X3
ensembl:ENSMUSP00000040944

P

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2X3
ensembl:ENSMUSP00000040944

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2X3
ensembl:ENSMUSP00000040944

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2X3
ensembl:ENSMUSP00000040944

F

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2X3
ensembl:ENSMUSP00000040944

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004365

F

Seeded From UniProt

complete

involved_in

GO:0016233

telomere capping

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014647

P

Seeded From UniProt

complete

enables

GO:0043047

single-stranded telomeric DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014647

F

Seeded From UniProt

complete

part_of

GO:1990879

CST complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014647

C

Seeded From UniProt

complete

involved_in

GO:0016233

telomere capping

PMID:22763445[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0779
UniProtKB-SubCell:SL-0276

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Miyake, Y et al. (2009) RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol. Cell 36 193-206 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Chen, LY et al. (2012) The human CST complex is a terminator of telomerase activity. Nature 488 540-4 PubMed GONUTS page
  3. ↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Wan, M et al. (2009) OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J. Biol. Chem. 284 26725-31 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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