HUMAN:STING

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TMEM173 (synonyms: ERIS, MITA, STING)
Protein Name(s)	Stimulator of interferon genes protein hSTING Endoplasmic reticulum interferon stimulator ERIS Mediator of IRF3 activation hMITA Transmembrane protein 173
External Links
UniProt	Q86WV6
EMBL	FJ222241 AK290661 AC138517 BC047779
CCDS	CCDS4215.1
RefSeq	NP_938023.1
UniGene	Hs.379754
PDB	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX
PDBsum	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX
ProteinModelPortal	Q86WV6
SMR	Q86WV6
BioGrid	130988
DIP	DIP-48847N
IntAct	Q86WV6
STRING	9606.ENSP00000331288
PhosphoSite	Q86WV6
BioMuta	TMEM173
DMDM	74727720
MaxQB	Q86WV6
PaxDb	Q86WV6
PRIDE	Q86WV6
DNASU	340061
Ensembl	ENST00000330794
GeneID	340061
UCSC	uc003lep.3
CTD	340061
GeneCards	TMEM173
HGNC	HGNC:27962
HPA	HPA038116 HPA038534
MIM	612374 615934
neXtProt	NX_Q86WV6
PharmGKB	PA162405934
eggNOG	NOG43926
GeneTree	ENSGT00390000008582
HOGENOM	HOG000076316
HOVERGEN	HBG094065
InParanoid	Q86WV6
OMA	TWMLALL
OrthoDB	EOG79GT88
PhylomeDB	Q86WV6
TreeFam	TF324444
Reactome	R-HSA-1606341 R-HSA-1834941 R-HSA-3134975 R-HSA-3249367 R-HSA-3270619
ChiTaRS	TMEM173
GenomeRNAi	340061
NextBio	97672
PRO	PR:Q86WV6
Proteomes	UP000005640
Bgee	Q86WV6
CleanEx	HS_TMEM173
ExpressionAtlas	Q86WV6
Genevisible	Q86WV6
GO	GO:0030659 GO:0005789 GO:0005794 GO:0016021 GO:0005741 GO:0048471 GO:0005777 GO:0005886 GO:0035438 GO:0061507 GO:0042802 GO:0042803 GO:0019901 GO:0008134 GO:0002218 GO:0006915 GO:0071360 GO:0035458 GO:0051607 GO:0045087 GO:0032608 GO:0002230 GO:0032092 GO:0033160 GO:0042993 GO:0045944 GO:0032481 GO:0032479
InterPro	IPR029158
Pfam	PF15009

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060340	negative regulation of signal transduction involved in conjugation with cellular fusion	PMID:25636800^[1]	ECO:0000315			P		Figure 5G. Both wild type huSTING and huIRF3 are required for IRF3 dimerization, signaling type I interferon production.	complete CACAO 11123
	GO:0023014	signal transduction by protein phosphorylation	PMID:25636800^[1]	ECO:0000314			P		Figure 1A and 3A shows greater IRF3 dimerization/phosphorylation in presence of MAVS. IRF3 dimerization leads to type I interferon production.	complete CACAO 11175
	GO:0007165	signal transduction	PMID:22394562^[2]	ECO:0000314			P		Figure 1	complete CACAO 11189
involved_in	GO:0061709	reticulophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3TBT3	P		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	PMID:29694889^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:29694889^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:29694889^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:29694889^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:29694889^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:22394562^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:30842659^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:30842659^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:30842659^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:30842659^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:23747010^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:23747010^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:30842662^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990701	integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	PMID:30842662^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:30842662^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:30842662^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:30842662^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:30568238^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:30568238^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:26669264^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:26669264^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:26669264^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:25254379^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:25254379^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:25254379^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:25254379^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:18818105^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18818105^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18818105^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_activity_of:(UniProtKB:Q14653)	Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:18818105^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18818105^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18818105^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:18818105^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	PMID:18818105^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:18818105^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3TBT3	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21074459^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3TBT3	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19433799^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21074459^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:22705373^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19433799^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21074459^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	PMID:22705373^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:19433799^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:21074459^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21074459^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WUN2	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:19433799^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 RGD:1562552 UniProtKB:A7SLZ2 UniProtKB:Q86WV6	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0039528	cytoplasmic pattern recognition receptor signaling pathway in response to virus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002154029 ZFIN:ZDB-GENE-120921-1	P		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:A7SLZ2 UniProtKB:Q86WV6	F		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 RGD:1562552 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	C		Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:30405246^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23542348^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22728660^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22728659^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22728658^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19433799^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029158	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029158	P		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033952	F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-3270619 Reactome:R-HSA-1834941	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032479	regulation of type I interferon production	Reactome:R-HSA-3134975	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	Reactome:R-HSA-8948709 Reactome:R-HSA-3249392 Reactome:R-HSA-3249390 Reactome:R-HSA-3249378 Reactome:R-HSA-3249371 Reactome:R-HSA-3244643 Reactome:R-HSA-2396009 Reactome:R-HSA-2396007 Reactome:R-HSA-2396002 Reactome:R-HSA-1834939	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-3244643 Reactome:R-HSA-3134804 Reactome:R-HSA-3134800 Reactome:R-HSA-2396009 Reactome:R-HSA-1964496	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page
↑ ^2.0 ^2.1 Tanaka, Y & Chen, ZJ (2012) STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5 ra20 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Konno, H et al. (2018) Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep 23 1112-1123 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Shang, G et al. (2019) Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567 389-393 PubMed GONUTS page
↑ ^5.0 ^5.1 Zhang, X et al. (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51 226-35 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gui, X et al. (2019) Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567 262-266 PubMed GONUTS page
↑ ^7.0 ^7.1 Liu, D et al. (2018) STING directly activates autophagy to tune the innate immune response. Cell Death Differ. PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zhang, H et al. (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5 18035 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Qin, Y et al. (2014) RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 10 e1004358 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Zhong, B et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 538-50 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Tsuchida, T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 765-76 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Sun, W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U.S.A. 106 8653-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Yin, Q et al. (2012) Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol. Cell 46 735-45 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ramanjulu, JM et al. (2018) Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 564 439-443 PubMed GONUTS page
↑ Ding, Q et al. (2013) Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J. Hepatol. 59 52-8 PubMed GONUTS page
↑ Shang, G et al. (2012) Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat. Struct. Mol. Biol. 19 725-7 PubMed GONUTS page
↑ Huang, YH et al. (2012) The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19 728-30 PubMed GONUTS page
↑ Shu, C et al. (2012) Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19 722-4 PubMed GONUTS page

[PMID:25636800-1] 1.0 ^1.1 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

[PMID:22394562-2] 2.0 ^2.1 Tanaka, Y & Chen, ZJ (2012) STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5 ra20 PubMed GONUTS page

[PMID:29694889-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Konno, H et al. (2018) Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep 23 1112-1123 PubMed GONUTS page

[PMID:30842659-4] 4.0 ^4.1 ^4.2 ^4.3 Shang, G et al. (2019) Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567 389-393 PubMed GONUTS page

[PMID:23747010-5] 5.0 ^5.1 Zhang, X et al. (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51 226-35 PubMed GONUTS page

[PMID:30842662-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gui, X et al. (2019) Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567 262-266 PubMed GONUTS page

[PMID:30568238-7] 7.0 ^7.1 Liu, D et al. (2018) STING directly activates autophagy to tune the innate immune response. Cell Death Differ. PubMed GONUTS page

[PMID:26669264-8] 8.0 ^8.1 ^8.2 Zhang, H et al. (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5 18035 PubMed GONUTS page

[PMID:25254379-9] 9.0 ^9.1 ^9.2 ^9.3 Qin, Y et al. (2014) RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 10 e1004358 PubMed GONUTS page

[PMID:18818105-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Zhong, B et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 538-50 PubMed GONUTS page

[PMID:21074459-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Tsuchida, T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 765-76 PubMed GONUTS page

[PMID:19433799-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Sun, W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U.S.A. 106 8653-8 PubMed GONUTS page

[PMID:22705373-13] 13.0 ^13.1 Yin, Q et al. (2012) Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol. Cell 46 735-45 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:30405246-15] Ramanjulu, JM et al. (2018) Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 564 439-443 PubMed GONUTS page

[PMID:23542348-16] Ding, Q et al. (2013) Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J. Hepatol. 59 52-8 PubMed GONUTS page

[PMID:22728660-17] Shang, G et al. (2012) Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat. Struct. Mol. Biol. 19 725-7 PubMed GONUTS page

[PMID:22728659-18] Huang, YH et al. (2012) The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19 728-30 PubMed GONUTS page

[PMID:22728658-19] Shu, C et al. (2012) Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19 722-4 PubMed GONUTS page

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