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HUMAN:STING

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TMEM173 (synonyms: ERIS, MITA, STING)
Protein Name(s) Stimulator of interferon genes protein

hSTING Endoplasmic reticulum interferon stimulator ERIS Mediator of IRF3 activation hMITA Transmembrane protein 173

External Links
UniProt Q86WV6
EMBL FJ222241
AK290661
AC138517
BC047779
CCDS CCDS4215.1
RefSeq NP_938023.1
UniGene Hs.379754
PDB 4EF4
4EF5
4EMT
4EMU
4F5D
4F5E
4F5W
4F5Y
4F9E
4F9G
4KSY
4LOH
4LOI
4QXO
4QXP
4QXQ
4QXR
5BQX
PDBsum 4EF4
4EF5
4EMT
4EMU
4F5D
4F5E
4F5W
4F5Y
4F9E
4F9G
4KSY
4LOH
4LOI
4QXO
4QXP
4QXQ
4QXR
5BQX
ProteinModelPortal Q86WV6
SMR Q86WV6
BioGrid 130988
DIP DIP-48847N
IntAct Q86WV6
STRING 9606.ENSP00000331288
PhosphoSite Q86WV6
BioMuta TMEM173
DMDM 74727720
MaxQB Q86WV6
PaxDb Q86WV6
PRIDE Q86WV6
DNASU 340061
Ensembl ENST00000330794
GeneID 340061
UCSC uc003lep.3
CTD 340061
GeneCards TMEM173
HGNC HGNC:27962
HPA HPA038116
HPA038534
MIM 612374
615934
neXtProt NX_Q86WV6
PharmGKB PA162405934
eggNOG NOG43926
GeneTree ENSGT00390000008582
HOGENOM HOG000076316
HOVERGEN HBG094065
InParanoid Q86WV6
OMA TWMLALL
OrthoDB EOG79GT88
PhylomeDB Q86WV6
TreeFam TF324444
Reactome R-HSA-1606341
R-HSA-1834941
R-HSA-3134975
R-HSA-3249367
R-HSA-3270619
ChiTaRS TMEM173
GenomeRNAi 340061
NextBio 97672
PRO PR:Q86WV6
Proteomes UP000005640
Bgee Q86WV6
CleanEx HS_TMEM173
ExpressionAtlas Q86WV6
Genevisible Q86WV6
GO GO:0030659
GO:0005789
GO:0005794
GO:0016021
GO:0005741
GO:0048471
GO:0005777
GO:0005886
GO:0035438
GO:0061507
GO:0042802
GO:0042803
GO:0019901
GO:0008134
GO:0002218
GO:0006915
GO:0071360
GO:0035458
GO:0051607
GO:0045087
GO:0032608
GO:0002230
GO:0032092
GO:0033160
GO:0042993
GO:0045944
GO:0032481
GO:0032479
InterPro IPR029158
Pfam PF15009

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060340

negative regulation of signal transduction involved in conjugation with cellular fusion

PMID:25636800[1]

ECO:0000315

P

Figure 5G. Both wild type huSTING and huIRF3 are required for IRF3 dimerization, signaling type I interferon production.

complete
CACAO 11123

GO:0023014

signal transduction by protein phosphorylation

PMID:25636800[1]

ECO:0000314

P

Figure 1A and 3A shows greater IRF3 dimerization/phosphorylation in presence of MAVS. IRF3 dimerization leads to type I interferon production.

complete
CACAO 11175

GO:0007165

signal transduction

PMID:22394562[2]

ECO:0000314

P

Figure 1

complete
CACAO 11189

involved_in

GO:0061709

reticulophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TBT3

P

Seeded From UniProt

complete

enables

GO:0035438

cyclic-di-GMP binding

PMID:29694889[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:29694889[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

PMID:29694889[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:29694889[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:29694889[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:22394562[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051259

protein complex oligomerization

PMID:30842659[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:30842659[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061507

cyclic-GMP-AMP binding

PMID:30842659[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:30842659[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:23747010[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061507

cyclic-GMP-AMP binding

PMID:23747010[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0061507

cyclic-GMP-AMP binding

PMID:30842662[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990701

integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

PMID:30842662[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:30842662[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:30842662[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:30842662[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:30568238[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:30568238[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061507

cyclic-GMP-AMP binding

PMID:26669264[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

PMID:26669264[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:26669264[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:25254379[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032608

interferon-beta production

PMID:25254379[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:25254379[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:25254379[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071360

cellular response to exogenous dsRNA

PMID:18818105[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18818105[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:18818105[10]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_activity_of:(UniProtKB:Q14653)

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

PMID:18818105[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:18818105[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:18818105[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:18818105[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002230

positive regulation of defense response to virus by host

PMID:18818105[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

PMID:18818105[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061507

cyclic-GMP-AMP binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TBT3

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21074459[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TBT3

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:19433799[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:21074459[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:22705373[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:19433799[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21074459[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0035438

cyclic-di-GMP binding

PMID:22705373[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032608

interferon-beta production

PMID:19433799[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032608

interferon-beta production

PMID:21074459[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21074459[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9WUN2

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:19433799[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071360

cellular response to exogenous dsRNA

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002154029
UniProtKB:Q86WV6

P

Seeded From UniProt

complete

enables

GO:0061507

cyclic-GMP-AMP binding

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
RGD:1562552
UniProtKB:A7SLZ2
UniProtKB:Q86WV6

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
UniProtKB:Q86WV6

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
UniProtKB:Q86WV6

P

Seeded From UniProt

complete

involved_in

GO:0039528

cytoplasmic pattern recognition receptor signaling pathway in response to virus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002154029
ZFIN:ZDB-GENE-120921-1

P

Seeded From UniProt

complete

enables

GO:0035438

cyclic-di-GMP binding

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
UniProtKB:A7SLZ2
UniProtKB:Q86WV6

F

Seeded From UniProt

complete

involved_in

GO:0032608

interferon-beta production

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
UniProtKB:Q86WV6

P

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
RGD:1562552
UniProtKB:Q86WV6

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919762
PANTHER:PTN002154029
UniProtKB:Q86WV6

C

Seeded From UniProt

complete

involved_in

GO:0002230

positive regulation of defense response to virus by host

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002154029
UniProtKB:Q86WV6

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:30405246[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86WV6

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23542348[16]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86WV6

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22728660[17]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86WV6

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22728659[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86WV6

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22728658[19]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86WV6

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19433799[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86WV6

F

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029158

P

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029158

P

Seeded From UniProt

complete

enables

GO:0035438

cyclic-di-GMP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033952

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

Reactome:R-HSA-3270619
Reactome:R-HSA-1834941

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0032479

regulation of type I interferon production

Reactome:R-HSA-3134975

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030667

secretory granule membrane

Reactome:R-HSA-6798743

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

Reactome:R-HSA-8948709
Reactome:R-HSA-3249392
Reactome:R-HSA-3249390
Reactome:R-HSA-3249378
Reactome:R-HSA-3249371
Reactome:R-HSA-3244643
Reactome:R-HSA-2396009
Reactome:R-HSA-2396007
Reactome:R-HSA-2396002
Reactome:R-HSA-1834939

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6798743

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-3244643
Reactome:R-HSA-3134804
Reactome:R-HSA-3134800
Reactome:R-HSA-2396009
Reactome:R-HSA-1964496

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page
  2. 2.0 2.1 Tanaka, Y & Chen, ZJ (2012) STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5 ra20 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Konno, H et al. (2018) Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep 23 1112-1123 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Shang, G et al. (2019) Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567 389-393 PubMed GONUTS page
  5. 5.0 5.1 Zhang, X et al. (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51 226-35 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Gui, X et al. (2019) Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567 262-266 PubMed GONUTS page
  7. 7.0 7.1 Liu, D et al. (2018) STING directly activates autophagy to tune the innate immune response. Cell Death Differ. PubMed GONUTS page
  8. 8.0 8.1 8.2 Zhang, H et al. (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5 18035 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Qin, Y et al. (2014) RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 10 e1004358 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 Zhong, B et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 538-50 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 Tsuchida, T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 765-76 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 Sun, W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U.S.A. 106 8653-8 PubMed GONUTS page
  13. 13.0 13.1 Yin, Q et al. (2012) Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol. Cell 46 735-45 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 14.8 14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  15. Ramanjulu, JM et al. (2018) Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 564 439-443 PubMed GONUTS page
  16. Ding, Q et al. (2013) Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J. Hepatol. 59 52-8 PubMed GONUTS page
  17. Shang, G et al. (2012) Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat. Struct. Mol. Biol. 19 725-7 PubMed GONUTS page
  18. Huang, YH et al. (2012) The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19 728-30 PubMed GONUTS page
  19. Shu, C et al. (2012) Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19 722-4 PubMed GONUTS page