GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:STING
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | TMEM173 (synonyms: ERIS, MITA, STING) | |
Protein Name(s) | Stimulator of interferon genes protein
hSTING Endoplasmic reticulum interferon stimulator ERIS Mediator of IRF3 activation hMITA Transmembrane protein 173 | |
External Links | ||
UniProt | Q86WV6 | |
EMBL | FJ222241 AK290661 AC138517 BC047779 | |
CCDS | CCDS4215.1 | |
RefSeq | NP_938023.1 | |
UniGene | Hs.379754 | |
PDB | 4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX | |
PDBsum | 4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX | |
ProteinModelPortal | Q86WV6 | |
SMR | Q86WV6 | |
BioGrid | 130988 | |
DIP | DIP-48847N | |
IntAct | Q86WV6 | |
STRING | 9606.ENSP00000331288 | |
PhosphoSite | Q86WV6 | |
BioMuta | TMEM173 | |
DMDM | 74727720 | |
MaxQB | Q86WV6 | |
PaxDb | Q86WV6 | |
PRIDE | Q86WV6 | |
DNASU | 340061 | |
Ensembl | ENST00000330794 | |
GeneID | 340061 | |
UCSC | uc003lep.3 | |
CTD | 340061 | |
GeneCards | TMEM173 | |
HGNC | HGNC:27962 | |
HPA | HPA038116 HPA038534 | |
MIM | 612374 615934 | |
neXtProt | NX_Q86WV6 | |
PharmGKB | PA162405934 | |
eggNOG | NOG43926 | |
GeneTree | ENSGT00390000008582 | |
HOGENOM | HOG000076316 | |
HOVERGEN | HBG094065 | |
InParanoid | Q86WV6 | |
OMA | TWMLALL | |
OrthoDB | EOG79GT88 | |
PhylomeDB | Q86WV6 | |
TreeFam | TF324444 | |
Reactome | R-HSA-1606341 R-HSA-1834941 R-HSA-3134975 R-HSA-3249367 R-HSA-3270619 | |
ChiTaRS | TMEM173 | |
GenomeRNAi | 340061 | |
NextBio | 97672 | |
PRO | PR:Q86WV6 | |
Proteomes | UP000005640 | |
Bgee | Q86WV6 | |
CleanEx | HS_TMEM173 | |
ExpressionAtlas | Q86WV6 | |
Genevisible | Q86WV6 | |
GO | GO:0030659 GO:0005789 GO:0005794 GO:0016021 GO:0005741 GO:0048471 GO:0005777 GO:0005886 GO:0035438 GO:0061507 GO:0042802 GO:0042803 GO:0019901 GO:0008134 GO:0002218 GO:0006915 GO:0071360 GO:0035458 GO:0051607 GO:0045087 GO:0032608 GO:0002230 GO:0032092 GO:0033160 GO:0042993 GO:0045944 GO:0032481 GO:0032479 | |
InterPro | IPR029158 | |
Pfam | PF15009 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0060340 |
negative regulation of signal transduction involved in conjugation with cellular fusion |
ECO:0000315 |
P |
Figure 5G. Both wild type huSTING and huIRF3 are required for IRF3 dimerization, signaling type I interferon production. |
complete | |||||
GO:0023014 |
signal transduction by protein phosphorylation |
ECO:0000314 |
P |
Figure 1A and 3A shows greater IRF3 dimerization/phosphorylation in presence of MAVS. IRF3 dimerization leads to type I interferon production. |
complete | |||||
GO:0007165 |
signal transduction |
ECO:0000314 |
P |
Figure 1 |
complete | |||||
involved_in |
GO:0061709 |
reticulophagy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035438 |
cyclic-di-GMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005776 |
autophagosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005768 |
endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0061507 |
cyclic-GMP-AMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0061507 |
cyclic-GMP-AMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0061507 |
cyclic-GMP-AMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:1990701 |
integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016239 |
positive regulation of macroautophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016239 |
positive regulation of macroautophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0061507 |
cyclic-GMP-AMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032608 |
interferon-beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071360 |
cellular response to exogenous dsRNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_activity_of:(UniProtKB:Q14653) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002218 |
activation of innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0061507 |
cyclic-GMP-AMP binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035438 |
cyclic-di-GMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032608 |
interferon-beta production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032608 |
interferon-beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071360 |
cellular response to exogenous dsRNA |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002154029 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0061507 |
cyclic-GMP-AMP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0039528 |
cytoplasmic pattern recognition receptor signaling pathway in response to virus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002154029 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035438 |
cyclic-di-GMP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032608 |
interferon-beta production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919762 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002154029 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002218 |
activation of innate immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035438 |
cyclic-di-GMP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
Reactome:R-HSA-3270619 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
involved_in |
GO:0032479 |
regulation of type I interferon production |
Reactome:R-HSA-3134975 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030667 |
secretory granule membrane |
Reactome:R-HSA-6798743 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
Reactome:R-HSA-8948709 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-6798743 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-3244643 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page
- ↑ 2.0 2.1 Tanaka, Y & Chen, ZJ (2012) STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5 ra20 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Konno, H et al. (2018) Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep 23 1112-1123 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Shang, G et al. (2019) Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567 389-393 PubMed GONUTS page
- ↑ 5.0 5.1 Zhang, X et al. (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51 226-35 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gui, X et al. (2019) Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567 262-266 PubMed GONUTS page
- ↑ 7.0 7.1 Liu, D et al. (2018) STING directly activates autophagy to tune the innate immune response. Cell Death Differ. PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Zhang, H et al. (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5 18035 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Qin, Y et al. (2014) RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 10 e1004358 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 Zhong, B et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 538-50 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 Tsuchida, T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 765-76 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 Sun, W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U.S.A. 106 8653-8 PubMed GONUTS page
- ↑ 13.0 13.1 Yin, Q et al. (2012) Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol. Cell 46 735-45 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 14.8 14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ramanjulu, JM et al. (2018) Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 564 439-443 PubMed GONUTS page
- ↑ Ding, Q et al. (2013) Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J. Hepatol. 59 52-8 PubMed GONUTS page
- ↑ Shang, G et al. (2012) Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat. Struct. Mol. Biol. 19 725-7 PubMed GONUTS page
- ↑ Huang, YH et al. (2012) The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19 728-30 PubMed GONUTS page
- ↑ Shu, C et al. (2012) Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19 722-4 PubMed GONUTS page
a
c
- Catarrhini
- GO:0071360 ! cellular response to exogenous dsRNA
- GO:0071407 ! cellular response to organic cyclic compound
- Chordata
- Craniata
- GO:0035438 ! cyclic-di-GMP binding
- GO:0005737 ! cytoplasm
- GO:0030659 ! cytoplasmic vesicle membrane
- GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
e
i
m
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0005886 ! plasma membrane
- GO:0060340 ! positive regulation of type I interferon-mediated signaling pathway
- GO:0016239 ! positive regulation of macroautophagy
- GO:0032092 ! positive regulation of protein binding
- GO:0032481 ! positive regulation of type I interferon production
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0002230 ! positive regulation of defense response to virus by host
- Primates
- GO:0051259 ! protein complex oligomerization
- GO:0042803 ! protein homodimerization activity
- GO:0019901 ! protein kinase binding
s