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HUMAN:SSRP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SSRP1 (synonyms: FACT80) | |
| Protein Name(s) | FACT complex subunit SSRP1
Chromatin-specific transcription elongation factor 80 kDa subunit Facilitates chromatin transcription complex 80 kDa subunit FACT 80 kDa subunit FACTp80 Facilitates chromatin transcription complex subunit SSRP1 Recombination signal sequence recognition protein 1 Structure-specific recognition protein 1 hSSRP1 T160 | |
| External Links | ||
| UniProt | Q08945 | |
| EMBL | M86737 BC005116 BC091486 | |
| CCDS | CCDS7952.1 | |
| PIR | A41976 | |
| RefSeq | NP_003137.1 | |
| UniGene | Hs.523680 | |
| PDB | 4IFS | |
| PDBsum | 4IFS | |
| ProteinModelPortal | Q08945 | |
| SMR | Q08945 | |
| BioGrid | 112627 | |
| DIP | DIP-169N | |
| IntAct | Q08945 | |
| MINT | MINT-5004485 | |
| STRING | 9606.ENSP00000278412 | |
| iPTMnet | Q08945 | |
| PhosphoSitePlus | Q08945 | |
| SwissPalm | Q08945 | |
| BioMuta | SSRP1 | |
| EPD | Q08945 | |
| MaxQB | Q08945 | |
| PaxDb | Q08945 | |
| PeptideAtlas | Q08945 | |
| PRIDE | Q08945 | |
| DNASU | 6749 | |
| Ensembl | ENST00000278412 | |
| GeneID | 6749 | |
| KEGG | hsa:6749 | |
| UCSC | uc001njt.3 | |
| CTD | 6749 | |
| DisGeNET | 6749 | |
| GeneCards | SSRP1 | |
| HGNC | HGNC:11327 | |
| HPA | HPA002697 | |
| MIM | 604328 | |
| neXtProt | NX_Q08945 | |
| OpenTargets | ENSG00000149136 | |
| PharmGKB | PA36151 | |
| eggNOG | KOG0526 COG5165 | |
| GeneTree | ENSGT00560000076898 | |
| HOGENOM | HOG000180790 | |
| HOVERGEN | HBG002932 | |
| InParanoid | Q08945 | |
| KO | K09272 | |
| OMA | HEVFTTV | |
| OrthoDB | EOG091G04JP | |
| PhylomeDB | Q08945 | |
| TreeFam | TF315228 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-112382 R-HSA-112382] [www.reactome.org/content/detail/R-HSA-112387 R-HSA-112387] [www.reactome.org/content/detail/R-HSA-167152 R-HSA-167152] [www.reactome.org/content/detail/R-HSA-167200 R-HSA-167200] [www.reactome.org/content/detail/R-HSA-167238 R-HSA-167238] [www.reactome.org/content/detail/R-HSA-167243 R-HSA-167243] [www.reactome.org/content/detail/R-HSA-167246 R-HSA-167246] [www.reactome.org/content/detail/R-HSA-167287 R-HSA-167287] [www.reactome.org/content/detail/R-HSA-167290 R-HSA-167290] [www.reactome.org/content/detail/R-HSA-674695 R-HSA-674695] [www.reactome.org/content/detail/R-HSA-6796648 R-HSA-6796648] [www.reactome.org/content/detail/R-HSA-6804756 R-HSA-6804756] [www.reactome.org/content/detail/R-HSA-75955 R-HSA-75955] | |
| SIGNOR | Q08945 | |
| ChiTaRS | SSRP1 | |
| GeneWiki | Structure_specific_recognition_protein_1 | |
| GenomeRNAi | 6749 | |
| PMAP-CutDB | Q08945 | |
| PRO | PR:Q08945 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000149136 | |
| CleanEx | HS_SSRP1 | |
| ExpressionAtlas | Q08945 | |
| Genevisible | Q08945 | |
| GO | GO:0005694 GO:0005730 GO:0005654 GO:0003682 GO:0003677 GO:0003723 GO:0006281 GO:0006260 GO:1901796 GO:0006355 GO:0006368 GO:0006366 | |
| Gene3D | 1.10.30.10 2.30.29.30 | |
| InterPro | IPR013719 IPR009071 IPR011993 IPR000969 IPR024954 | |
| Pfam | PF00505 PF08512 PF03531 | |
| PRINTS | PR00887 | |
| SMART | SM00398 SM01287 | |
| SUPFAM | SSF47095 SSF50729 | |
| PROSITE | PS50118 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0000981 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08943 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
Reactome:R-HSA-75955 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006366 |
transcription by RNA polymerase II |
Reactome:R-HSA-73857 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6805061 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006260 |
DNA replication |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
| GO:1902275 |
regulation of chromatin organization |
ECO:0000314 |
P |
In Figure 3, The presence of FACT increases the efficiency of RSC-induced nucleosome mobilization. |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ Bruhn, SL et al. (1992) Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Proc. Natl. Acad. Sci. U.S.A. 89 2307-11 PubMed GONUTS page
- ↑ Charles Richard, JL et al. (2016) FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC. PLoS Genet. 12 e1006221 PubMed GONUTS page
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