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HUMAN:SRBS1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SORBS1 (ECO:0000312 with HGNC:HGNC:14565) (synonyms: KIAA0894, KIAA1296, SH3D5)
Protein Name(s) Sorbin and SH3 domain-containing protein 1

Ponsin SH3 domain protein 5 SH3P12 c-Cbl-associated protein CAP

External Links
UniProt Q9BX66
EMBL AF136380
AF356525
AF356526
AF356527
AF330623
AF330624
AF136381
AJ489942
AM260536
AB037717
AL117472
AL158165
AL158165
AL158165
AL158165
AL158165
AL158165
AL158165
AL158165
CH471066
CH471066
BC042612
BC152463
U70668
CCDS CCDS31252.1
CCDS31253.1
CCDS31254.1
CCDS31255.1
CCDS31256.1
CCDS73169.1
CCDS7442.1
CCDS76326.1
CCDS76327.1
PIR T17257
RefSeq NP_001030126.1
NP_001030127.1
NP_001030128.1
NP_001030129.1
NP_001277223.1
NP_001277224.1
NP_001277225.1
NP_001277226.1
NP_001277227.1
NP_006425.2
NP_056200.1
NP_079267.1
XP_006717644.1
XP_006717652.1
XP_006717654.1
XP_006717658.1
UniGene Hs.38621
PDB 2DL3
2ECZ
2LJ0
2LJ1
2MOX
2O2W
2O31
2O9S
2O9V
4LN2
4LNP
PDBsum 2DL3
2ECZ
2LJ0
2LJ1
2MOX
2O2W
2O31
2O9S
2O9V
4LN2
4LNP
ProteinModelPortal Q9BX66
SMR Q9BX66
BioGrid 115831
IntAct Q9BX66
MINT MINT-2792261
STRING 9606.ENSP00000355136
PhosphoSite Q9BX66
BioMuta SORBS1
DMDM 317373504
MaxQB Q9BX66
PaxDb Q9BX66
PRIDE Q9BX66
DNASU 10580
Ensembl ENST00000277982
ENST00000306402
ENST00000354106
ENST00000361941
ENST00000371227
ENST00000371239
ENST00000371241
ENST00000371245
ENST00000371246
ENST00000371247
ENST00000371249
ENST00000607232
GeneID 10580
KEGG hsa:10580
UCSC uc001kkl.3
uc001kkm.3
uc001kkn.3
uc001kko.3
uc001kkp.3
uc001kkq.3
uc001kkr.3
uc001kks.3
uc001kkv.3
uc001kkw.3
CTD 10580
GeneCards GC10M097061
HGNC HGNC:14565
HPA HPA027559
HPA043084
MIM 605264
neXtProt NX_Q9BX66
PharmGKB PA37899
eggNOG NOG256936
GeneTree ENSGT00760000119190
HOVERGEN HBG053053
InParanoid Q9BX66
KO K06086
OMA DYIDLPF
OrthoDB EOG75XGKP
PhylomeDB Q9BX66
TreeFam TF320680
Reactome REACT_20558
SignaLink Q9BX66
ChiTaRS SORBS1
EvolutionaryTrace Q9BX66
GeneWiki SORBS1
GenomeRNAi 10580
NextBio 40165
PRO PR:Q9BX66
Proteomes UP000005640
Bgee Q9BX66
ExpressionAtlas Q9BX66
Genevisible Q9BX66
GO GO:0005913
GO:0005924
GO:0005813
GO:0005737
GO:0005829
GO:0005925
GO:0045121
GO:0016363
GO:0005654
GO:0005634
GO:0005886
GO:0001725
GO:0005915
GO:0003779
GO:0008092
GO:0005158
GO:0005070
GO:0007160
GO:0032869
GO:0048041
GO:0015758
GO:0008286
GO:0006936
GO:0090004
GO:0046326
GO:0045725
GO:0046889
GO:0009967
GO:0043149
InterPro IPR028506
IPR011511
IPR001452
IPR003127
PANTHER PTHR10661:SF4
Pfam PF07653
PF14604
PF02208
SMART SM00326
SM00459
SUPFAM SSF50044
PROSITE PS50002
PS50831

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005915

zonula adherens

ECO:0000304

C

Source: ProtInc

Missing: reference

GO:0003779

actin binding

ECO:0000304

F

Source: ProtInc

Missing: reference

involved_in

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

involved_in

GO:1903078

positive regulation of protein localization to plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

involved_in

GO:0046889

positive regulation of lipid biosynthetic process

PMID:11001060[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

PMID:11001060[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

involved_in

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:11001060[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

PMID:11001060[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

colocalizes_with

GO:0005899

insulin receptor complex

PMID:11374898[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9447983[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

C

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:11374898[2]

ECO:0000305

curator inference used in manual assertion

GO:0005158

F

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:9447983[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

F

Seeded From UniProt

complete

involved_in

GO:0048041

focal adhesion assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

C

Seeded From UniProt

complete

involved_in

GO:0043149

stress fiber assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

happens_during:(GO:0032868)

Seeded From UniProt

complete

involved_in

GO:0008286

insulin receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

P

Seeded From UniProt

complete

part_of

GO:0005924

cell-substrate adherens junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

C

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11371513[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005158

insulin receptor binding

PMID:11374898[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0001725

stress fiber

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62417

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007015

actin filament organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028506

P

Seeded From UniProt

complete

enables

GO:0008092

cytoskeletal protein binding

PMID:10085297[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007160

cell-matrix adhesion

PMID:10085297[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005915

zonula adherens

PMID:10085297[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

PMID:10085297[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:10085297[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006936

muscle contraction

Reactome:R-HSA-445355

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-445705
Reactome:R-HSA-445704
Reactome:R-HSA-445700
Reactome:R-HSA-445699

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005912

adherens junction

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0009

C

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0181

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0118

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Baumann, CA et al. (2000) CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407 202-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Lin, WH et al. (2001) Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Genomics 74 12-20 PubMed GONUTS page
  3. ↑ 3.0 3.1 Ribon, V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol. Cell. Biol. 18 872-9 PubMed GONUTS page
  4. ↑ Lebre, AS et al. (2001) Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions. Hum. Mol. Genet. 10 1201-13 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Mandai, K et al. (1999) Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J. Cell Biol. 144 1001-17 PubMed GONUTS page
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