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HUMAN:SPT5H

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SUPT5H (synonyms: SPT5, SPT5H)
Protein Name(s) Transcription elongation factor SPT5

hSPT5 DRB sensitivity-inducing factor 160 kDa subunit DSIF p160 DRB sensitivity-inducing factor large subunit DSIF large subunit Tat-cotransactivator 1 protein Tat-CT1 protein

External Links
UniProt O00267
EMBL U56402
Y12790
AB000516
AF040253
AB209257
BC024203
CCDS CCDS12536.1
CCDS46072.1
RefSeq NP_001104490.1
NP_001124296.1
NP_001124297.1
NP_003160.2
XP_005259240.1
XP_006723400.1
UniGene Hs.631604
PDB 2DO3
2E6Z
2E70
3H7H
4L1U
PDBsum 2DO3
2E6Z
2E70
3H7H
4L1U
ProteinModelPortal O00267
SMR O00267
BioGrid 112697
DIP DIP-29014N
IntAct O00267
MINT MINT-1193818
STRING 9606.ENSP00000367784
PhosphoSite O00267
MaxQB O00267
PaxDb O00267
PRIDE O00267
DNASU 6829
Ensembl ENST00000359191
ENST00000402194
ENST00000598725
ENST00000599117
GeneID 6829
KEGG hsa:6829
UCSC uc002oln.4
uc002olq.4
CTD 6829
GeneCards GC19P039936
HGNC HGNC:11469
HPA CAB034370
HPA029273
MIM 602102
neXtProt NX_O00267
PharmGKB PA36255
eggNOG COG0250
GeneTree ENSGT00440000037640
HOGENOM HOG000038564
HOVERGEN HBG079775
InParanoid O00267
KO K15172
OMA SRTPGWN
OrthoDB EOG7Z3F3Q
PhylomeDB O00267
TreeFam TF105730
BioCyc MetaCyc:G66-31601-MONOMER
Reactome REACT_1470
REACT_22107
REACT_22201
REACT_6143
REACT_6162
REACT_6237
REACT_6244
REACT_6259
REACT_6261
REACT_6319
REACT_6344
REACT_6346
REACT_833
REACT_846
REACT_975
ChiTaRS SUPT5H
EvolutionaryTrace O00267
GeneWiki SUPT5H
GenomeRNAi 6829
NextBio 26663
PRO PR:O00267
Proteomes UP000005640
Bgee O00267
CleanEx HS_SUPT5H
ExpressionAtlas O00267
Genevestigator O00267
GO GO:0032044
GO:0005654
GO:0005634
GO:0003682
GO:0019899
GO:0044822
GO:0046982
GO:0006370
GO:0007049
GO:0006338
GO:0006354
GO:0010467
GO:0032785
GO:0000122
GO:0032786
GO:0016239
GO:0045944
GO:0050434
GO:0010033
GO:0039692
GO:0006368
GO:0006366
GO:0016032
InterPro IPR005824
IPR006645
IPR024945
IPR022581
IPR017071
IPR005100
IPR008991
Pfam PF00467
PF03439
PF11942
PIRSF PIRSF036945
SMART SM01104
SM00739
SM00738
SUPFAM SSF50104

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1900364

negative regulation of mRNA polyadenylation

PMID:19575011[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(ENSEMBL:ENSG00000158373)

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:22354037[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9450929[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63272

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9450929[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

PMID:9450929[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032785

negative regulation of DNA-templated transcription, elongation

PMID:9450929[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032785

negative regulation of DNA-templated transcription, elongation

PMID:10075709[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032044

DSIF complex

PMID:9450929[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:10075709[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P24928

F

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:9450929[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:10075709[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10075709[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9450929[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:10075709[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032044

DSIF complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040273
PANTHER:PTN000122628
PomBase:SPAC23C4.19
SGD:S000004470
UniProtKB:O00267

C

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040273
PANTHER:PTN000122628
UniProtKB:O00267

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000122628
ZFIN:ZDB-GENE-001207-1

P

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040273
PANTHER:PTN000122628

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTB2
ensembl:ENSRNOP00000049521

P

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O55201
ensembl:ENSMUSP00000147164

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006645
InterPro:IPR036735

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017071
InterPro:IPR039659

P

Seeded From UniProt

complete

involved_in

GO:0032784

regulation of DNA-templated transcription, elongation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017071
InterPro:IPR039659

P

Seeded From UniProt

complete

involved_in

GO:0050434

positive regulation of viral transcription

Reactome:R-HSA-167246

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006370

7-methylguanosine mRNA capping

Reactome:R-HSA-72086

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

Reactome:R-HSA-75955
Reactome:R-HSA-113418
Reactome:R-HSA-112382

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

Reactome:R-HSA-73857

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-77090
Reactome:R-HSA-77085
Reactome:R-HSA-77083
Reactome:R-HSA-77081
Reactome:R-HSA-77078
Reactome:R-HSA-77077
Reactome:R-HSA-77073
Reactome:R-HSA-6797616
Reactome:R-HSA-6797606
Reactome:R-HSA-170706
Reactome:R-HSA-170704
Reactome:R-HSA-113429
Reactome:R-HSA-113414
Reactome:R-HSA-113413
Reactome:R-HSA-113412
Reactome:R-HSA-113411
Reactome:R-HSA-113409
Reactome:R-HSA-113407
Reactome:R-HSA-113402
Reactome:R-HSA-112434
Reactome:R-HSA-112396
Reactome:R-HSA-112395
Reactome:R-HSA-112392
Reactome:R-HSA-112385
Reactome:R-HSA-112381
Reactome:R-HSA-112379

ECO:0000304

author statement supported by traceable reference used in manual assertion


























C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Pirngruber, J et al. (2009) CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. EMBO Rep. 10 894-900 PubMed GONUTS page
  2. ↑ McKnight, NC et al. (2012) Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J. 31 1931-46 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Wada, T et al. (1998) DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev. 12 343-56 PubMed GONUTS page
  4. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  5. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Yamaguchi, Y et al. (1999) Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem. 274 8085-92 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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