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HUMAN:SNAT
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | AANAT (synonyms: SNAT) | |
| Protein Name(s) | Serotonin N-acetyltransferase
Serotonin acetylase Aralkylamine N-acetyltransferase AA-NAT | |
| External Links | ||
| UniProt | Q16613 | |
| EMBL | U40347 U40391 AC015802 BC069434 BC092430 BC126332 BC126334 | |
| CCDS | CCDS11745.1 CCDS54169.1 | |
| RefSeq | NP_001079.1 NP_001160051.1 | |
| UniGene | Hs.431417 | |
| ProteinModelPortal | Q16613 | |
| SMR | Q16613 | |
| BioGrid | 106533 | |
| IntAct | Q16613 | |
| MINT | MINT-1559914 | |
| STRING | 9606.ENSP00000250615 | |
| BindingDB | Q16613 | |
| DMDM | 11387096 | |
| PaxDb | Q16613 | |
| PRIDE | Q16613 | |
| DNASU | 15 | |
| Ensembl | ENST00000250615 ENST00000392492 | |
| GeneID | 15 | |
| KEGG | hsa:15 | |
| UCSC | uc002jro.3 | |
| CTD | 15 | |
| GeneCards | GC17P074449 | |
| HGNC | HGNC:19 | |
| HPA | HPA050784 | |
| MIM | 600950 614163 | |
| neXtProt | NX_Q16613 | |
| PharmGKB | PA24366 | |
| eggNOG | NOG324206 | |
| GeneTree | ENSGT00390000015579 | |
| HOGENOM | HOG000115812 | |
| HOVERGEN | HBG016332 | |
| InParanoid | Q16613 | |
| KO | K00669 | |
| OMA | LRRNSGC | |
| OrthoDB | EOG7C2R2B | |
| PhylomeDB | Q16613 | |
| TreeFam | TF331622 | |
| BioCyc | MetaCyc:HS05303-MONOMER | |
| Reactome | REACT_15439 | |
| UniPathway | UPA00837 | |
| GenomeRNAi | 15 | |
| NextBio | 35534776 | |
| PMAP-CutDB | Q16613 | |
| PRO | PR:Q16613 | |
| Proteomes | UP000005640 | |
| Bgee | Q16613 | |
| CleanEx | HS_AANAT | |
| ExpressionAtlas | Q16613 | |
| Genevestigator | Q16613 | |
| GO | GO:0005829 GO:0048471 GO:0004059 GO:0004060 GO:0034641 GO:0071320 GO:0007623 GO:0046219 GO:0030187 GO:0006474 GO:0051592 GO:0046688 GO:0051412 GO:0034097 GO:0032868 GO:0009416 GO:0034695 GO:0010043 GO:0044281 | |
| Gene3D | 3.40.630.30 | |
| InterPro | IPR016181 IPR000182 | |
| Pfam | PF00583 | |
| SUPFAM | SSF55729 | |
| PROSITE | PS51186 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051047 |
positive regulation of secretion |
ECO:0000314 |
P |
fig 4 Kinetic analysis of 1E7 AANAT |
complete | |||||
|
involved_in |
GO:0071320 |
cellular response to cAMP |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030187 |
melatonin biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030187 |
melatonin biosynthetic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006474 |
N-terminal protein amino acid acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004059 |
aralkylamine N-acetyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:28790)|has_direct_input:(CHEBI:2089) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004059 |
aralkylamine N-acetyltransferase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030187 |
melatonin biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000097491 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009416 |
response to light stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000097491 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000097491 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000097489 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004059 |
aralkylamine N-acetyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000097489 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004060 |
arylamine N-acetyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O88816 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901652 |
response to peptide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0071889 |
14-3-3 protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051592 |
response to calcium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051591 |
response to cAMP |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051412 |
response to corticosterone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046688 |
response to copper ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034695 |
response to prostaglandin E |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032868 |
response to insulin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010043 |
response to zinc ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009648 |
photoperiodism |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009416 |
response to light stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004059 |
aralkylamine N-acetyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64666 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004059 |
aralkylamine N-acetyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046219 |
indolalkylamine biosynthetic process |
Reactome:R-HSA-209931 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-209792 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004059 |
aralkylamine N-acetyltransferase activity |
Reactome:R-HSA-209792 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030187 |
melatonin biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0471 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Coon, SL et al. (2001) cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. J. Biol. Chem. 276 24097-107 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Coon, SL et al. (1996) The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics 34 76-84 PubMed GONUTS page
- ↑ Hohjoh, H et al. (2003) Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics 4 151-3 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
p
r
- GO:0032868 ! response to insulin
- GO:0034097 ! response to cytokine
- GO:0034695 ! response to prostaglandin E
- GO:0046688 ! response to copper ion
- GO:0051412 ! response to corticosterone
- GO:0051591 ! response to cAMP
- GO:0051592 ! response to calcium ion
- GO:1901652 ! response to peptide
- GO:0009416 ! response to light stimulus
- GO:0010043 ! response to zinc ion
- GO:0048511 ! rhythmic process
