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PMID:8661026
| Citation |
Coon, SL, Mazuruk, K, Bernard, M, Roseboom, PH, Klein, DC and Rodriguez, IR (1996) The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics 34:76-84 |
|---|---|
| Abstract |
Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, HGMW-approved symbol AANAT; EC 2.3.1.87) is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. We have found that the human AA-NAT gene spans approximately 2.5 kb, contains four exons, and is located at chromosome 17q25. The open reading frame encodes a 23.2-kDa protein that is approximately 80% identical to sheep and rat AA-NAT. The AA-NAT transcript (approximately 1 kb) is highly abundant in the pineal gland and is expressed at lower levels in the retina and in the Y79 retinoblastoma cell line. AA-NAT mRNA is also detectable at low levels in several brain regions and the pituitary gland, but not in several peripheral tissues examined. Brain and pituitary AA-NAT could modulate serotonin-dependent aspects of human behavior and pituitary function. |
| Links |
PubMed Online version:10.1006/geno.1996.0243 |
| Keywords |
Amino Acid Sequence; Animals; Arylalkylamine N-Acetyltransferase; Arylamine N-Acetyltransferase/biosynthesis; Arylamine N-Acetyltransferase/genetics; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 17; Conserved Sequence; DNA, Complementary; Humans; Molecular Sequence Data; Pineal Gland/physiology; RNA, Messenger/analysis; Rats; Retina/chemistry; Retina/metabolism; Retinoblastoma/genetics; Retinoblastoma/pathology; Sequence Analysis, DNA; Sheep; Tissue Distribution; Tumor Cells, Cultured |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0004059: aralkylamine N-acetyltransferase activity |
ECO:0000303: author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007623: circadian rhythm |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030187: melatonin biosynthetic process |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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