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HUMAN:SIR7

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SIRT7 (synonyms: SIR2L7)
Protein Name(s) NAD-dependent protein deacetylase sirtuin-7

Regulatory protein SIR2 homolog 7 SIR2-like protein 7

External Links
UniProt Q9NRC8
EMBL AF233395
AK002027
AK094326
AK290265
AC145207
BC017305
BC101791
BC101793
AL137626
CCDS CCDS11792.1
PIR T46324
RefSeq NP_057622.1
UniGene Hs.514636
ProteinModelPortal Q9NRC8
SMR Q9NRC8
BioGrid 119602
DIP DIP-59906N
IntAct Q9NRC8
MINT MINT-1424083
STRING 9606.ENSP00000329466
ChEMBL CHEMBL2163184
DMDM 38258650
MaxQB Q9NRC8
PaxDb Q9NRC8
PRIDE Q9NRC8
DNASU 51547
Ensembl ENST00000328666
GeneID 51547
KEGG hsa:51547
UCSC uc002kcj.2
CTD 51547
GeneCards GC17M079869
HGNC HGNC:14935
HPA CAB037261
MIM 606212
neXtProt NX_Q9NRC8
PharmGKB PA37940
eggNOG COG0846
GeneTree ENSGT00530000063706
HOGENOM HOG000231240
HOVERGEN HBG060028
InParanoid Q9NRC8
KO K11417
OMA EVCTACT
OrthoDB EOG7M98GV
PhylomeDB Q9NRC8
TreeFam TF106184
ChiTaRS SIRT7
GeneWiki SIRT7
GenomeRNAi 51547
NextBio 35463912
PRO PR:Q9NRC8
Proteomes UP000005640
Bgee Q9NRC8
CleanEx HS_SIRT7
ExpressionAtlas Q9NRC8
Genevestigator Q9NRC8
GO GO:0005737
GO:0005730
GO:0005731
GO:0003682
GO:0046872
GO:0070403
GO:0097372
GO:0070932
GO:0070933
GO:0000122
GO:0007072
GO:0009303
Gene3D 3.40.50.1220
InterPro IPR029035
IPR003000
IPR026590
PANTHER PTHR11085
Pfam PF02146
SUPFAM SSF52467
PROSITE PS50305

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0097372

NAD-dependent histone deacetylase activity (H3-K18 specific)

PMID:22722849[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070932

histone H3 deacetylation

PMID:22722849[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009303

rRNA transcription

PMID:19174463[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007072

positive regulation of transcription involved in exit from mitosis

PMID:19174463[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005731

nucleolus organizer region

PMID:19174463[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:16079181[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:22722849[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:22722849[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070933

histone H4 deacetylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0097372

P

Seeded From UniProt

complete

enables

GO:0070403

NAD+ binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003000

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Barber, MF et al. (2012) SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487 114-8 PubMed GONUTS page
  2. 2.0 2.1 2.2 Grob, A et al. (2009) Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J. Cell. Sci. 122 489-98 PubMed GONUTS page
  3. Michishita, E et al. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 4623-35 PubMed GONUTS page