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HUMAN:SIR7
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | SIRT7 (synonyms: SIR2L7) | |
Protein Name(s) | NAD-dependent protein deacetylase sirtuin-7
Regulatory protein SIR2 homolog 7 SIR2-like protein 7 | |
External Links | ||
UniProt | Q9NRC8 | |
EMBL | AF233395 AK002027 AK094326 AK290265 AC145207 BC017305 BC101791 BC101793 AL137626 | |
CCDS | CCDS11792.1 | |
PIR | T46324 | |
RefSeq | NP_057622.1 | |
UniGene | Hs.514636 | |
ProteinModelPortal | Q9NRC8 | |
SMR | Q9NRC8 | |
BioGrid | 119602 | |
DIP | DIP-59906N | |
IntAct | Q9NRC8 | |
MINT | MINT-1424083 | |
STRING | 9606.ENSP00000329466 | |
ChEMBL | CHEMBL2163184 | |
DMDM | 38258650 | |
MaxQB | Q9NRC8 | |
PaxDb | Q9NRC8 | |
PRIDE | Q9NRC8 | |
DNASU | 51547 | |
Ensembl | ENST00000328666 | |
GeneID | 51547 | |
KEGG | hsa:51547 | |
UCSC | uc002kcj.2 | |
CTD | 51547 | |
GeneCards | GC17M079869 | |
HGNC | HGNC:14935 | |
HPA | CAB037261 | |
MIM | 606212 | |
neXtProt | NX_Q9NRC8 | |
PharmGKB | PA37940 | |
eggNOG | COG0846 | |
GeneTree | ENSGT00530000063706 | |
HOGENOM | HOG000231240 | |
HOVERGEN | HBG060028 | |
InParanoid | Q9NRC8 | |
KO | K11417 | |
OMA | EVCTACT | |
OrthoDB | EOG7M98GV | |
PhylomeDB | Q9NRC8 | |
TreeFam | TF106184 | |
ChiTaRS | SIRT7 | |
GeneWiki | SIRT7 | |
GenomeRNAi | 51547 | |
NextBio | 35463912 | |
PRO | PR:Q9NRC8 | |
Proteomes | UP000005640 | |
Bgee | Q9NRC8 | |
CleanEx | HS_SIRT7 | |
ExpressionAtlas | Q9NRC8 | |
Genevestigator | Q9NRC8 | |
GO | GO:0005737 GO:0005730 GO:0005731 GO:0003682 GO:0046872 GO:0070403 GO:0097372 GO:0070932 GO:0070933 GO:0000122 GO:0007072 GO:0009303 | |
Gene3D | 3.40.50.1220 | |
InterPro | IPR029035 IPR003000 IPR026590 | |
PANTHER | PTHR11085 | |
Pfam | PF02146 | |
SUPFAM | SSF52467 | |
PROSITE | PS50305 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0097372 |
NAD-dependent histone deacetylase activity (H3-K18 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070932 |
histone H3 deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009303 |
rRNA transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007072 |
positive regulation of transcription involved in exit from mitosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005731 |
nucleolus organizer region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070933 |
histone H4 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0097372 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Barber, MF et al. (2012) SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487 114-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Grob, A et al. (2009) Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J. Cell. Sci. 122 489-98 PubMed GONUTS page
- ↑ Michishita, E et al. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 4623-35 PubMed GONUTS page
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