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HUMAN:SF3B3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SF3B3 (synonyms: KIAA0017, SAP130)
Protein Name(s) Splicing factor 3B subunit 3

Pre-mRNA-splicing factor SF3b 130 kDa subunit SF3b130 STAF130 Spliceosome-associated protein 130 SAP 130

External Links
UniProt Q15393
EMBL AJ001443
D87686
D13642
BC000463
BC003146
BC009780
BC068974
AL110251
CCDS CCDS10894.1
PIR T14779
RefSeq NP_036558.3
UniGene Hs.514435
ProteinModelPortal Q15393
SMR Q15393
BioGrid 117016
DIP DIP-28152N
IntAct Q15393
MINT MINT-1402891
STRING 9606.ENSP00000305790
BindingDB Q15393
ChEMBL CHEMBL1250378
PhosphoSite Q15393
DMDM 116242787
MaxQB Q15393
PaxDb Q15393
PeptideAtlas Q15393
PRIDE Q15393
Ensembl ENST00000302516
GeneID 23450
KEGG hsa:23450
UCSC uc002ezf.3
CTD 23450
GeneCards GC16P070557
HGNC HGNC:10770
HPA HPA042986
MIM 605592
neXtProt NX_Q15393
PharmGKB PA35688
eggNOG NOG247734
GeneTree ENSGT00530000063396
HOGENOM HOG000216677
HOVERGEN HBG093942
InParanoid Q15393
KO K12830
OMA HPKGIRH
OrthoDB EOG7N8ZTN
PhylomeDB Q15393
TreeFam TF105685
Reactome REACT_1753
REACT_467
ChiTaRS SF3B3
GeneWiki SF3B3
GenomeRNAi 23450
NextBio 45731
PRO PR:Q15393
Proteomes UP000005640
Bgee Q15393
CleanEx HS_SAP130
HS_SF3B3
ExpressionAtlas Q15393
Genevestigator Q15393
GO GO:0071013
GO:0005654
GO:0030532
GO:0005681
GO:0005689
GO:0003676
GO:0010467
GO:0006397
GO:0000398
GO:0006461
GO:0008380
GO:0000375
InterPro IPR004871
IPR017986
Pfam PF03178
SUPFAM SSF50978

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:29360106[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:29360106[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071005

U2-type precatalytic spliceosome

PMID:29360106[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:28781166[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28781166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071005

U2-type precatalytic spliceosome

PMID:28781166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:11564863[3]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-900

F

Seeded From UniProt

complete

involved_in

GO:0042177

negative regulation of protein catabolic process

PMID:23951410[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0042177

negative regulation of protein catabolic process

PMID:23951410[4]

ECO:0000314

P

In Figure 2, it is shown that transfection of SAP130 decreases the rate of degradation in p27 compared to an empty vector.

complete
CACAO 8506

part_of

GO:0071013

catalytic step 2 spliceosome

PMID:11991638[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005689

U12-type spliceosomal complex

PMID:15146077[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:11991638[5]

ECO:0000305

curator inference used in manual assertion

GO:0071013

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000068362
PomBase:SPAC17H9.10c
PomBase:SPAPJ698.03c
TAIR:locus:2127368
TAIR:locus:2153122
UniProtKB:A1A4K3
UniProtKB:Q15393
UniProtKB:Q16531
UniProtKB:Q5BFT4
UniProtKB:Q6L4S0
UniProtKB:Q9M0V3
dictyBase:DDB_G0286013

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000068443
SGD:S000004513
UniProtKB:Q15393

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004871

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004871

C

Seeded From UniProt

complete

involved_in

GO:0000375

RNA splicing, via transesterification reactions

PMID:10490618[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-75083
Reactome:R-HSA-75082
Reactome:R-HSA-75081
Reactome:R-HSA-75080
Reactome:R-HSA-75079
Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-72139
Reactome:R-HSA-72130
Reactome:R-HSA-72127
Reactome:R-HSA-72124
Reactome:R-HSA-156661

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72165
Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005681

spliceosomal complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0747

C

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Zhang, X et al. (2018) Structure of the human activated spliceosome in three conformational states. Cell Res. 28 307-322 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Bertram, K et al. (2017) Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170 701-713.e11 PubMed GONUTS page
  3. ↑ Martinez, E et al. (2001) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol. 21 6782-95 PubMed GONUTS page
  4. ↑ 4.0 4.1 Cordero-Espinoza, L & Hagen, T (2013) Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130). Biol Open 2 838-44 PubMed GONUTS page
  5. ↑ 5.0 5.1 Jurica, MS et al. (2002) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8 426-39 PubMed GONUTS page
  6. ↑ Will, CL et al. (2004) The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA 10 929-41 PubMed GONUTS page
  7. ↑ 7.0 7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Das, BK et al. (1999) Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol. Cell. Biol. 19 6796-802 PubMed GONUTS page
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